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Neuropeptide Y Receptor

Neuropeptide Y Receptor

The G protein-coupled receptor superfamily includes several subtypes of neuropeptide Y receptors. The terms Y1, Y2, Y4, Y5, and Y6 refer to the five cloned NPY receptor subtypes in mammals. Vasoconstriction and feeding are two physiological responses that are mediated by neuropeptide Y receptors.

Humans express the Y1, Y2, Y4, and Y5 subtypes. They are primarily found in tissues like the cardiovascular system and the central and peripheral nervous systems. The neurotransmitter Neuropeptide Y, as well as the hormones peptide YY (PYY) and pancreatic polypeptide (PP), are their physiological ligands.

Important biological and pathophysiological processes like blood pressure, neuroendocrine secretions, seizures, neuronal excitability, and neuroplasticity are regulated by neuropeptide Y and its receptors.

Neuropeptide Y Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(Leu31,Pro34)-Peptide YY (human) V70841 (Leu31,Pro34)-Peptide YY (human) 179986-95-9 (Leu31,Pro34)-Peptide YY (human) is a bioactive peptide YY analogue and a potent and specific Y1 agonist/activator with a KD of 1.0 nM.
(Leu31,Pro34)-Peptide YY (human) (TFA) V77382 (Leu31,Pro34)-Peptide YY (human) (TFA) (Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human).
(Pro34)-Peptide YY (human) V70827 (Pro34)-Peptide YY (human) 179986-93-7 (Pro34)-Peptide YY (human) is a highly Y1-selective full agonist of the Peptide YY neuropeptide Y receptor.
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide V70824 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 313988-89-5 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and specific neuropeptide YY5 receptor agonist, with IC50 of 0.24 nM for binding to hY5 receptors.
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA V77474 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and specific neuropeptide YY5 receptor agonist, with IC50 of 0.24 nM for binding to hY5 receptors.
[D-Arg25]-Neuropeptide Y (human) V80166 [D-Arg25]-Neuropeptide Y (human) [D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a selective agonist of the Y1 receptor.
[D-Trp34]-Neuropeptide Y V70825 [D-Trp34]-Neuropeptide Y 153549-84-9 [D-Trp34]-Neuropeptide Y is a specific neuropeptide Y (NPY) Y5 receptor agonist.
[D-Trp34]-Neuropeptide Y TFA V77478 [D-Trp34]-Neuropeptide Y TFA [D-Trp34]-Neuropeptide Y TFA is a specific neuropeptide Y (NPY) Y5 receptor agonist.
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA V77339 [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y1 receptor agonist.
Ala5-Galanin (2-11) V70838 Ala5-Galanin (2-11) 859843-84-8 Ala5-Galanin(2-11) is a specific agonist of alanine receptor 2 (GAL2R) with Ki of 258 nM.
AR-M1896 V70833 AR-M1896 367518-31-8 AR-M1896 is a GalR2 selective agonist/activator with a binding IC50 of 1.76 nM for rat GalR2.
BIBO3304 diTFA V84624 BIBO3304 diTFA 2310085-85-7
BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) V84871 BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) 246146-31-6
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) V77207 BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) BIIE-0246 HCl (AR-H 053591 HCl) is a potent and specific neuroγ receptor 2 NPY2R antagonist (inhibitor) with IC50 of 15 nM for rat [125I]PYY3-36 site.
BMS-193885 L-Lactic acid V70832 BMS-193885 L-Lactic acid 679839-66-8 BMS-193885 (L-Lactic acid) is a specific, brain-penetrating neuropeptide Y1 receptor antagonist.
CART (1-39), Human, Rat V78646 CART (1-39), Human, Rat CART (1-39), Human, Rat is a neuropeptide consisting of residues 1-39 of the CART peptide.
CART (55-76), rat V70840 CART (55-76), rat 1815618-15-5 CART (55-76), rat is a neuropeptide (consisting of residues 55-76 of the CART peptide) that constitutes the n-terminal fragment of CART (55-102).
CART(55-102)(human) TFA V78647 CART(55-102)(human) TFA CART(55-102)(human) TFA is a human satiety factor that strongly suppresses appetite and is closely related to leptin and neuropeptide Y.
CART(55-102)(rat) TFA V78648 CART(55-102)(rat) TFA CART(55-102)(rat) TFA is a mouse-derived satiety factor that strongly suppresses appetite, is closely related to leptin and neuropeptide Y, and can induce anxiety and stress-related behaviors.
Galanin (1-16), mouse, porcine, rat TFA V76991 Galanin (1-16), mouse, porcine, rat TFA Galanin (1-16), mouse, porcine, rat (TFA) is a galanin receptor agonist (activator) with Kd of 3 nM.
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