The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V37554 | 2',3'-cGAMP sodium | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is an endogenous cGAMP molecule found in mammalian cells, it binds to STING with high affinity and is a potent inducer of interferon-β (IFNβ). | |
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V115292 | 2'2'-cGAMP disodium | 2'2'-cGAMP disodium is a synthetic cyclic dinucleotide (CDN) that can bind to STING in an immune response and induce the production of IFN-β. | |
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V116448 | 3'2'-cGAMP | 1615704-64-7 | 3'2'-cGAMP (c[A(2',5')pG(3',5')p]) is a cyclic guanylate-adenosine monophosphate (cGAMP) isomer. |
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V111574 | 5'-Phosphoguanylyl-(3',5')-guanosine trisodium | 5'-Guanine phosphate-(3',5')-guanosine trisodium (pGpG trisodium) is an intermediate molecule produced by the enzymatic degradation pathway of cyclic guanosine phosphate (c-di-GMP). | |
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V100084 | 8K13-hz35-STING-D4-1203 | 2228893-47-6 | 8K13-hz35-STING-D4-1203 is an ADC drug-linker conjugate. |
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V32421 | ADU-S100 disodium salt | 1638750-95-4 | ADU-S100 disodium salt (MIW815; MIW-815; ML RR-S2-CDA)is the first agonist of stimulator of interferon genes (STING), with immunomodulatory and antitumor activities. |
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V32420 | ADU-S100 ammonium salt | 1638750-96-5 | ADU-S100 ammonium salt (ADUS100; ML RR-S2 CDA; MIW815) is potent STING agonist with anticancer and immunomodulatory activities. |
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V87004 | AK59 | AK59 is a STING degrader that functions by utilizing HERC4, a het domain E3 ligase. | |
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V78019 | Anti-inflammatory agent 65 | 3035442-58-8 | Anti-inflammatory agent 65 (compound 29) is a hederic acid analogue with potent anti-inflammatory activity. |
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V84407 | Anti-inflammatory agent 70 | ||
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V74326 | Antitumor agent-114 | 2757762-91-5 | Antitumor agent-114 is a potent stimulatory interferon gene (STING) agonist. |
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V104527 | BDW-OH | 573976-22-4 | BDW-OH is the active metabolite of BDW568, a STING agonist that selectively activates the human STINGA230 allele. |
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V87009 | BDW568 | 335401-44-0 | BDW568 is a STING agonist that selectively activates the human STINGA230 allele. |
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V74306 | BI 7446 | 2767011-00-5 | BI 7446 is a potent and specific stimulating interferon gene (STING) agonist based on cyclic dinucleotides (CDN). |
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V117742 | c-(2'FdAMP-2'FdIMP) | 1951464-78-0 | c-(2'FdAMP-2'FdIMP) (compound 52) is a derivative of cAIMP, a cyclic dinucleotide (CDN). |
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V2342 | C-170 | 346691-38-1 | STING-IN-2 (C-170) is a potent and covalent STING inhibitor. |
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V2343 | C-171 | 2244881-69-2 | STING-IN-3 is an inhibitor (blocker/antagonist) of the stimulatory receptor for interferon genes (STING). |
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V3831 | C-176 | 314054-00-7 | C-176 is a highly potent,covalent/irreversible and selective small-molecule antagonist/inhibitor of the stimulator of interferon genes (STING) protein, which is a central signalling component of the intracellular DNA sensing pathway. |
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V17400 | C-178 | 329198-87-0 | C-178 is a covalent inhibitor of STING whichbinds to Cys91,blocking palmitoylation-induced clustering of STING. |
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V51262 | c-di-AMP diammonium | STING agonist |
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