The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V37554 | 2',3'-cGAMP sodium | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is an endogenous cGAMP molecule found in mammalian cells, it binds to STING with high affinity and is a potent inducer of interferon-β (IFNβ). | |
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V32420 | ADU-S100 ammonium salt | 1638750-96-5 | ADU-S100 ammonium salt (ADUS100; ML RR-S2 CDA; MIW815) is potent STING agonist with anticancer and immunomodulatory activities. |
|
V32421 | ADU-S100 disodium salt | 1638750-95-4 | ADU-S100 disodium salt (MIW815; MIW-815; ML RR-S2-CDA)is the first agonist of stimulator of interferon genes (STING), with immunomodulatory and antitumor activities. |
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V78019 | Anti-inflammatory agent 65 | Anti-inflammatory agent 65 (compound 29) is a hederic acid analogue with potent anti-inflammatory activity. | |
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V74326 | Antitumor agent-114 | 2757762-91-5 | Antitumor agent-114 is a potent stimulatory interferon gene (STING) agonist. |
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V74306 | BI 7446 | 2767011-00-5 | BI 7446 is a potent and specific stimulating interferon gene (STING) agonist based on cyclic dinucleotides (CDN). |
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V2342 | C-170 | 346691-38-1 | STING-IN-2 (C-170) is a potent and covalent STING inhibitor. |
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V2343 | C-171 | 2244881-69-2 | STING-IN-3 is an inhibitor (blocker/antagonist) of the stimulatory receptor for interferon genes (STING). |
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V3831 | C-176 | 314054-00-7 | C-176 is a highly potent,covalent/irreversible and selective small-molecule antagonist/inhibitor of the stimulator of interferon genes (STING) protein, which is a central signalling component of the intracellular DNA sensing pathway. |
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V17400 | C-178 | 329198-87-0 | C-178 is a covalent inhibitor of STING whichbinds to Cys91,blocking palmitoylation-induced clustering of STING. |
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V51262 | c-di-AMP diammonium | STING agonist | |
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V51261 | c-di-AMP disodium | 2734909-87-4 | Sodium c-di-AMP (cyclic diadenylate) is a STING agonist that binds to STING, thereby activating the TBK3-IRF3 signaling pathway and triggering the production of type I IFN and TNF. |
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V74318 | C-di-IMP (Cyclic-di-IMP) | 79940-41-3 | C-di-IMP (Cyclic-di-IMP) is a STING agonist. |
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V78697 | C-di-IMP disodium (Cyclic-di-IMP disodium) | C-di-IMP disodium is a STING agonist. | |
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V74321 | CDN-A | 2586047-09-6 | CDN-A is a cyclic dinucleotide that may be utilized to prepare antibody-active molecule conjugates (ADC). |
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V5330 | cGAMP disodium (Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium) | 2407516-83-8 | cGAMP (also known as Cyclic GMP-AMP; 3,3-cGAMP) is a cyclic nucleotide acting as a STING agonist. |
|
V41344 | ChX710 | 2438721-44-7 | ChX710 is a biochemical that can prime the type I interferon response to cytosolic DNA, thus inducing the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3. |
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V78816 | CL845-PAB-Ala-Val-C5-MC | CL845-PAB-Ala-Val-C5-MC is a binding STING ligand synthesized from the proprietary cyclic dinucleotide CL845. | |
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V78817 | CL845-PAB-Ala-Val-PEG4-Azide | CL845-PAB-Ala-Val-PEG4-Azide is a binding STING ligand synthesized from the proprietary cyclic dinucleotide CL845. | |
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V18802 | Cridanimod | 38609-97-1 | Cridanimod (XBIO-101;XBIO101; Virexxa) is a novel and potent immunomodulator and interferon inducer withantineoplastic activity. |
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