STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.Initially, STAT proteins were thought to be dormant cytoplasmic transcription factors that needed to be phosphorylated in order to be retained in the nucleus. While awaiting an activation signal, the unphosphorylated STAT proteins move back and forth between the cytosol and the nucleus. The transcription of cytokine-inducible genes is activated once the activated transcription factor enters the nucleus and binds to the consensus DNA-recognition motif known as gamma-activated sites (GAS) in the promoter region.

STAT related products

Structure Cat No. Product Name CAS No. Product Description
V69139 (R)-Lisofylline ((R)-Lisophylline) 100324-81-0
V69136 Angoline 21080-31-9
V69143 Angoline hydrochloride 1071676-04-4
V69156 Antitumor agent-73 2812356-72-0
V69144 APT STAT3 1345420-96-3
V2003 Artesunate 88495-63-0 Artesunate (Amivas; SM-804; WR-256283; HSDB-7458;Armax 200), an approved antimalaria agent, is a semisynthetic derivative of artemisinin with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.
V2981 AS1517499 919486-40-1 AS1517499 is a potent STAT6 inhibitor with IC50of 21 nM.
V2547 BP-1-102 1334493-07-0 BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, which binds Stat3 with an affinity Kd of 504 nM.
V4972 Cucurbitacin I 2222-07-3 Cucurbitacin I, a naturally occurring triterpene analog, is a novel, potent and selective inhibitor of JAK2/STAT3 with potent anti-cancer activity on a variety of cancer cell types.
V69157 Eflepedocokin alfa 2200269-84-5
V18077 Golotimod (SCV07) 229305-39-9 Golotimod (Orilotimod, SCV-07), is a potent and orally bioavailable synthetic peptide with an immunomodulating and antimicrobial activities.
V22020 GYY 4137 morpholine salt 106740-09-4 GYY 4137 morpholine salt (GYY-4137; GYY4137; ZYJ1122; ZYJ-1122) is a novel, water-soluble and slow releasing Hydrogen sulfide (H2S) donor.
V9650 Homoharringtonine (HHT) 26833-87-4 Homoharringtonine (Omacetaxine mepesuccinate and HHT; trade name Synribo) is a naturally occurring and cytotoxic pharmaceutical substance that is indicated for treatment of chronic myeloid leukemia (CML).
V76918 HP590
V22577 inS3-54-A18 328998-53-4 inS3-54-A18 is a STAT3 inhibitor, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo.
V69138 ML115 912798-42-6
V2259 Narciclasine 29477-83-6 Narciclasine is a toxic plant growth modulator found in various Amaryllidaceae species.
V69151 Neocucurbitacin A 352359-53-6
V7042 RO8191 691868-88-9 RO8191(RO-8191; CDM-3008) is a novel and potent activator of JAK/STAT pathway andinterferon α receptor type 2 (IFNAR2) with antiviral effects.
V67544 ROCK2-IN-7 3000541-95-4
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