Serum- and glucocorticoid-inducible kinases (SGKs) form a novel family of serine/threonine kinases that are activated in response to a variety of extracellular stimuli. Three isoforms of the SGK family exist: SGK1, SGK2, and SGK3. A variety of stimuli, such as growth factors, steroid and peptide hormones, cytokines, changes in cell volume, and brain injury, quickly induce the mRNA encoding SGK1, the most thoroughly studied member of the SGK family.
Akt (also known as PKB), a serine/threonine kinase that is essential for promoting cell survival, is related to SGKs. The SGK family members communicate downstream of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and are similar to AKT in terms of structure, substrate specificity, and function.They control a number of fundamental cellular functions, including cell survival and proliferation, and as a result, have a significant impact on the emergence of cancer. Additionally, through an AKT-independent signaling pathway, SGKs not only control cell proliferation and survival but also play significant roles in the development of cancer. It is urgent to find and develop small molecule inhibitors targeting SGK for PIK3CA mutant cancers, especially those that are resistant to AKT inhibition, given the significance of SGKs in the development of cancer and the dearth of effective and selective SGK inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V9678 | EMD638683 | 1181770-72-8 | EMD638683 is a potent inhibitor of SGK1 with an IC50 of 3 μM. |
|
V3541 | GSK 650394 | 890842-28-1 | GSK650394 (GSK-650394) is a novel and potentcompetitive inhibitor of SGK1 (serum and glucocorticoid-regulated kinase 1) with anticancer effects. |
|
V73860 | SGK1-IN-3 | 2891696-18-5 | SGK1-IN-3 (compound 3a) is a potent, orally bioactive SGK1 inhibitor. |
|
V87729 | SGK1-IN-3 hydrochloride | SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active SGK1 inhibitor. | |
|
V73859 | SGK1-IN-4 | 1628048-93-0 | SGK1-IN-4 (compound 17a) is a selective orally bioactive SGK1 inhibitor. |
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