SGK

SGK

Serum- and glucocorticoid-inducible kinases (SGKs) form a novel family of serine/threonine kinases that are activated in response to a variety of extracellular stimuli. Three isoforms of the SGK family exist: SGK1, SGK2, and SGK3. A variety of stimuli, such as growth factors, steroid and peptide hormones, cytokines, changes in cell volume, and brain injury, quickly induce the mRNA encoding SGK1, the most thoroughly studied member of the SGK family.

Akt (also known as PKB), a serine/threonine kinase that is essential for promoting cell survival, is related to SGKs. The SGK family members communicate downstream of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and are similar to AKT in terms of structure, substrate specificity, and function.They control a number of fundamental cellular functions, including cell survival and proliferation, and as a result, have a significant impact on the emergence of cancer. Additionally, through an AKT-independent signaling pathway, SGKs not only control cell proliferation and survival but also play significant roles in the development of cancer. It is urgent to find and develop small molecule inhibitors targeting SGK for PIK3CA mutant cancers, especially those that are resistant to AKT inhibition, given the significance of SGKs in the development of cancer and the dearth of effective and selective SGK inhibitors.

SGK related products

Structure Cat No. Product Name CAS No. Product Description
V9678 EMD638683 1181770-72-8 EMD638683 is a potent inhibitor of SGK1 with an IC50 of 3 μM.
V3541 GSK 650394 890842-28-1 GSK650394 (GSK-650394) is a novel and potentcompetitive inhibitor of SGK1 (serum and glucocorticoid-regulated kinase 1) with anticancer effects.
V73860 SGK1-IN-3 2891696-18-5
V73859 SGK1-IN-4 1628048-93-0
Contact Us