DNA Methyltransferase

DNA Methyltransferase

DNA methylation, which is the addition of a methyl group to the carbon atom five (C5) of cytosine, is carried out by a family of "writer" enzymes called DNA methyltransferases (DNMTs). De novo methyltransferases (DNMT3A-DNMT3B), DNMT1, DNMT2, DNMT3C, and DNMTL are the five DNMTs that mammals encode. The three active enzymes that maintain DNA methylation are DNMT1, DNMT3A, and DNMT3B. While DNMT2 functions as a tRNA transferase rather than a DNA methyltransferase, DNMT3L lacks catalytic activity and regulates DNMT3A and DNMT3B.
By regulating gene expression without altering the DNA sequence, DNA methylation is a crucial modification process in the control of genetic information. For transcription, post-replicative mismatch repair, DNA replication control, cell cycle control, bacterial virulence, and the distinction between self and non-self DNA in prokaryotes, DNA methylation is crucial. DNA methylation is essential for many important physiological processes in mammals, including imprinting, the inactivation of the X chromosome, the silencing of germline-specific genes, and the silencing of repetitive elements.

DNA Methyltransferase related products

Structure Cat No. Product Name CAS No. Product Description
V1974 (-)-Epigallocatechin Gallate 989-51-5 Epigallocatechin Gallate (also known as EGCG; epigallocatechin-3-gallate)is a naturally occurring catechin extractied from green tea, which shows multiple bioactivity.
V75481 AluI Methyltransferase (AluI ) 92228-38-1
V0404 Azacitidine (Ladakamycin; 5-AzaC) 320-67-2 5-Azacytidine (5AzaC; Ladakamycin; U-18496; Vidaza;Mylosar;5-AzaC) is an FDA approved anticancer drug bearing a pyrimidine nucleoside core and belongs to cytosine class of antimetabolites.
V75482 BamHI Methyltransferase (BamHI Methyltransferase) 92228-39-2
V34699 Benzyl selenocyanate 4671-93-6
V4331 BOBCAT339 2280037-51-4 Bobcat339 is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2).
V4930 Bobcat339 HCl 2436747-44-1 Bobcat339 HCl is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2).
V52332 Bobcat339 hydrochloride 2436747-44-1
V19260 DC_05 890643-16-0 DC_05 is a novel and potent selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1).
V0403 Decitabine (NSC-127716) 2353-33-5 Decitabine (also known as Deoxycytidine;5-aza-dCyd; NSC 127716; 5-Aza-2-deoxycytidine; deoxyazacytidine; dezocitidine; Brand name: Dacogen.
V35015 Dihydro-5-azacytidine (DHAC; NSC 264880) 62488-57-7
V35016 Dihydro-5-azacytidine acetate (DHAC acetate; NSC 264880 acetate) 2470972-18-8
V52165 DNMT-IN-1 2396691-28-2
V17621 DNMT-IN-3 1683516-27-9
V79844 DNMT2-IN-1
V75485 EcoRI Methyltransferase (EcoRI Methyltransferase) 81458-00-6
V79641 GpC Methyltransferase (GpC )
V37622 GSK-3484862 2170136-65-7 GSK-3484862 (GSK3484862) is a novel, potent and non-covalent Dnmt1(DNA methyltransferase) inhibitor with potential anticancer activity.
V52034 GSK3735967 2170136-86-2
V75480 HaeIII Methyltransferase (HaeIII) 92228-40-5
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