DNA methylation, which is the addition of a methyl group to the carbon atom five (C5) of cytosine, is carried out by a family of "writer" enzymes called DNA methyltransferases (DNMTs). De novo methyltransferases (DNMT3A-DNMT3B), DNMT1, DNMT2, DNMT3C, and DNMTL are the five DNMTs that mammals encode. The three active enzymes that maintain DNA methylation are DNMT1, DNMT3A, and DNMT3B. While DNMT2 functions as a tRNA transferase rather than a DNA methyltransferase, DNMT3L lacks catalytic activity and regulates DNMT3A and DNMT3B.
By regulating gene expression without altering the DNA sequence, DNA methylation is a crucial modification process in the control of genetic information. For transcription, post-replicative mismatch repair, DNA replication control, cell cycle control, bacterial virulence, and the distinction between self and non-self DNA in prokaryotes, DNA methylation is crucial. DNA methylation is essential for many important physiological processes in mammals, including imprinting, the inactivation of the X chromosome, the silencing of germline-specific genes, and the silencing of repetitive elements.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1974 | (-)-Epigallocatechin Gallate | 989-51-5 | Epigallocatechin Gallate (also known as EGCG; epigallocatechin-3-gallate)is a naturally occurring catechin extractied from green tea, which shows multiple bioactivity. |
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V75481 | AluI Methyltransferase (AluI ) | 92228-38-1 | AluI Methyltransferase (AluI) is a methyltransferase used as an interferase to study selectivity. |
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V0404 | Azacitidine (Ladakamycin; 5-AzaC) | 320-67-2 | 5-Azacytidine (5AzaC; Ladakamycin; U-18496; Vidaza;Mylosar;5-AzaC) is an FDA approved anticancer drug bearing a pyrimidine nucleoside core and belongs to cytosine class of antimetabolites. |
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V75482 | BamHI Methyltransferase (BamHI Methyltransferase) | 92228-39-2 | BamHI Methyltransferase is a DNA methyltransferase that modifies specific cytosines (GGATCC). |
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V34699 | Benzyl selenocyanate | 4671-93-6 | Benzyl selenocyanate is a chemopreventive agent used in the initiation and post-initiation phases of various chemically induced tumors in animal models. |
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V4331 | BOBCAT339 | 2280037-51-4 | Bobcat339 is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). |
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V4930 | Bobcat339 HCl | 2436747-44-1 | Bobcat339 HCl is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). |
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V52332 | Bobcat339 hydrochloride | 2436747-44-1 | Bobcat339 HCl is a potent and specific cytosine-based TET enzyme inhibitor (antagonist) with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. |
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V19260 | DC_05 | 890643-16-0 | DC-05 is a DNMT1 inhibitor (antagonist) with IC50 and Kds of 10.3 μM and 1.09 μM respectively. |
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V0403 | Decitabine (NSC-127716) | 2353-33-5 | Decitabine (also known as Deoxycytidine;5-aza-dCyd; NSC 127716; 5-Aza-2-deoxycytidine; deoxyazacytidine; dezocitidine; Brand name: Dacogen. |
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V35015 | Dihydro-5-azacytidine (DHAC; NSC 264880) | 62488-57-7 | Dihydro-5-azacytidine (DHAC) is a nucleoside analog that can be incorporated into DNA and inhibit DNA methylation. |
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V35016 | Dihydro-5-azacytidine acetate (DHAC acetate; NSC 264880 acetate) | 2470972-18-8 | Dihydro-5-azacytidine acetate (DHAC) is a nucleoside analog that can be incorporated into DNA and inhibit DNA methylation. |
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V52165 | DNMT-IN-1 | 2396691-28-2 | DNMT-IN-1 is a potent DNMT inhibitor (antagonist) with EC50 of 3.2 µM. |
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V17621 | DNMT-IN-3 | 1683516-27-9 | DNMT-IN-3 is a DNA methyltransferase (DNA Methyltransferase) DNMT inhibitor (antagonist) with anti-malarial effect, with IC50 of 60 nM against Plasmodium falciparum. |
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V79844 | DNMT2-IN-1 | DNMT2-IN-1 (compound 80) is a novel DNMT2 (DNA methyltransferase 2) inhibitor (antagonist) with IC50 of 1.2 μM for research into psychiatric and metabolic disorders or cancer diseases. | |
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V75485 | EcoRI Methyltransferase (EcoRI Methyltransferase) | 81458-00-6 | EcoRI Methyltransferase is a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase. |
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V79641 | GpC Methyltransferase (GpC ) | GpC Methyltransferase (GpC) is a DNA methylase. | |
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V37622 | GSK-3484862 | 2170136-65-7 | GSK-3484862 (GSK3484862) is a novel, potent and non-covalent Dnmt1(DNA methyltransferase) inhibitor with potential anticancer activity. |
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V52034 | GSK3735967 | 2170136-86-2 | GSK3735967 is a selective, reversible, non-nucleoside DNMT1 inhibitor. |
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V75480 | HaeIII Methyltransferase (HaeIII) | 92228-40-5 | HaeIII Methyltransferase (HaeIII) is a methyltransferase that covalently binds to DNA. |
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