DNA methylation, which is the addition of a methyl group to the carbon atom five (C5) of cytosine, is carried out by a family of "writer" enzymes called DNA methyltransferases (DNMTs). De novo methyltransferases (DNMT3A-DNMT3B), DNMT1, DNMT2, DNMT3C, and DNMTL are the five DNMTs that mammals encode. The three active enzymes that maintain DNA methylation are DNMT1, DNMT3A, and DNMT3B. While DNMT2 functions as a tRNA transferase rather than a DNA methyltransferase, DNMT3L lacks catalytic activity and regulates DNMT3A and DNMT3B.
By regulating gene expression without altering the DNA sequence, DNA methylation is a crucial modification process in the control of genetic information. For transcription, post-replicative mismatch repair, DNA replication control, cell cycle control, bacterial virulence, and the distinction between self and non-self DNA in prokaryotes, DNA methylation is crucial. DNA methylation is essential for many important physiological processes in mammals, including imprinting, the inactivation of the X chromosome, the silencing of germline-specific genes, and the silencing of repetitive elements.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V88845 | (S)-Kaempferide | (S)-Kaempferide (ZINC167686681) is a DNA methyltransferase (DNMT) inhibitor. | |
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V88842 | 5-Aza-4'-thio-2'-deoxycytidine | 169514-76-5 | 5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally available inhibitor of DNA methyltransferase I (DNMT1). |
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V0403 | Decitabine (NSC-127716) | 2353-33-5 | Decitabine (also known as Deoxycytidine;5-aza-dCyd; NSC 127716; 5-Aza-2-deoxycytidine; deoxyazacytidine; dezocitidine; Brand name: Dacogen. |
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V0404 | Azacitidine (Ladakamycin; 5-AzaC) | 320-67-2 | 5-Azacytidine (5AzaC; Ladakamycin; U-18496; Vidaza;Mylosar;5-AzaC) is an FDA approved anticancer drug bearing a pyrimidine nucleoside core and belongs to cytosine class of antimetabolites. |
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V0406 | Thioguanine (NSC-752; Tabloid) | 154-42-7 | Thioguanine (6-Thioguanine; NSC752; Tabloid; 2-Amino-6-purinethiol; 6-TG), an FDA approved medication used for treating AML-acute myeloid leukemia, is an antimetabolite anticancer drug, specifically, an anti-leukemia and immunosuppressant agent. |
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V75481 | AluI Methyltransferase (AluI ) | 92228-38-1 | AluI Methyltransferase (AluI) is a methyltransferase used as an interferase to study selectivity. |
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V75482 | BamHI Methyltransferase (BamHI Methyltransferase) | 92228-39-2 | BamHI Methyltransferase is a DNA methyltransferase that modifies specific cytosines (GGATCC). |
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V34699 | Benzyl selenocyanate | 4671-93-6 | Benzyl selenocyanate is a chemopreventive agent used in the initiation and post-initiation phases of various chemically induced tumors in animal models. |
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V88850 | BM30 | 2606862-05-7 | BM30, a peptide mimetic, is a selective inhibitor of NTMT1 and NTMT2 (IC50: 0.89 μM for NTMT1). |
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V4331 | BOBCAT339 | 2280037-51-4 | Bobcat339 is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). |
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V4930 | Bobcat339 HCl | 2436747-44-1 | Bobcat339 HCl is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). |
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V88848 | CM-444 | CM-444 is an inhibitor of HDAC (IC50 6 nM-0.6 μM) and DNA methyltransferase (DNMT, IC50 1.8-2.3 μM). | |
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V88225 | CNP0296775 | CNP0296775 is a dengue virus methyltransferase (DENV MTase) inhibitor with the potential to disrupt the viral replication process. | |
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V19260 | DC_05 | 890643-16-0 | DC-05 is a DNMT1 inhibitor (antagonist) with IC50 and Kds of 10.3 μM and 1.09 μM respectively. |
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V35015 | Dihydro-5-azacytidine (DHAC; NSC 264880) | 62488-57-7 | Dihydro-5-azacytidine (DHAC) is a nucleoside analog that can be incorporated into DNA and inhibit DNA methylation. |
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V35016 | Dihydro-5-azacytidine acetate (DHAC acetate; NSC 264880 acetate) | 2470972-18-8 | Dihydro-5-azacytidine acetate (DHAC) is a nucleoside analog that can be incorporated into DNA and inhibit DNA methylation. |
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V52165 | DNMT-IN-1 | 2396691-28-2 | DNMT-IN-1 is a potent DNMT inhibitor (antagonist) with EC50 of 3.2 µM. |
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V17621 | DNMT-IN-3 | 1683516-27-9 | DNMT-IN-3 is a DNA methyltransferase (DNA Methyltransferase) DNMT inhibitor (antagonist) with anti-malarial effect, with IC50 of 60 nM against Plasmodium falciparum. |
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V88844 | DNMT/HDAC-IN-1 | 2095619-17-1 | DNMT/HDAC-IN-1 (Compund 15a) is a dual inhibitor of DNMT and HDAC with IC50 values of 56.84 nM and 17.39 nM for HDAC1 and HDAC6, respectively. |
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V88843 | DNMT1-IN-3 | 3025012-68-1 | DNMT1-IN-3 (compound 7t-S) is a potent DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 of 0.777 μM and a KD of 0.183 μM. |