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Wnt(beta)-catenin

Wnt(beta)-catenin

A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).

Wnt(beta)-catenin related products

Structure Cat No. Product Name CAS No. Product Description
Adavivint (SM04690) V4124 Adavivint (SM04690) 1467093-03-3 Adavivint (formerly known as SM04690) is a novel, potent, specific/selective inhibitor ofcanonical Wnt signaling pathway with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter in SW480 colon cancer cells.
AMBMP V3347 AMBMP 853220-52-7 Decription: AMBMP (also known as BML-284; BML284) is a novel, potent and cell-permeable Wnt signaling activator with anti-inflammatory activity.
AMBMP hydrochloride V10977 AMBMP hydrochloride 2095432-75-8 BML-284 HCl is a potent cell-penetrating/penetrable Wnt signaling activator.
BML-284 HCl V22031 BML-284 HCl 853220-52-7 Decription: BML-284 HCl (AMBMP and Wnt agonist 1) is a potent and selective activator of Wnt signaling with anti-inflammatory activity.
Cardiogenol C V39052 Cardiogenol C 671225-39-1 Cardiogenol C is a potent cell-penetrable pyrimidine inducer that promotes ESCs differentiation into cardiomyocytes (EC50=100 nM).
Cardiogenol C HCl V17578 Cardiogenol C HCl 1049741-55-0 Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 of 0.1 µM.
CCT-251545 V5055 CCT-251545 1661839-45-7 CCT251545 is a novel, potent, selective and orally bioavailable small-molecule inhibitor of WNT signaling with an IC50of 5 nM in 7dF3 cells.
Coronaridine V51020 Coronaridine 467-77-6 Coronaridine, an alkaloid, inhibits the wnt signaling pathway by reducing β-catenin expression.
exo-IWR-1 V2434 exo-IWR-1 1127442-87-8 exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is used as a negative control of IWR-1 (V1351) which is apotenttankyrase inhibitor of the Wnt pathway with potential antitumor activity.
Gigantol V29660 Gigantol 67884-30-4 Gigantol is a bibenzyl compound derived from several medicinal orchids.
HLY78 V4879 HLY78 854847-61-3 HLY78 is a novel and potent small molecule activator of theWnt/β-cateninsignaling pathway which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.
iCRT14 V5249 iCRT14 677331-12-3 iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with IC50of 40.3 nM against Wnt responsive STF16 luciferase in a homogeneous fluorescence polarization (FP) assay.
iCRT3 V3194 iCRT3 901751-47-1 iCRT3 (iCRT-3) is an inhibitor of Wnt and β-catenin-responsive transcription in the Wnt/wingless signaling pathway with anticancer activity.
IQ-1 V3000 IQ-1 331001-62-8 IQ-1 (IQ1) is a cell-permeable tetrahydroisoquinolinylidene small molecule compound that modulates Wnt/beta-catenin signaling.
IWP-3 V22784 IWP-3 687561-60-0 IWP-3 is a potent inhibitor of Wnt production with IC50 of 40 nM.
IWP-4 V22785 IWP-4 686772-17-8 IWP-4 is a small molecule Wnt inhibitor (antagonist) with IC50 of 25 nM.
JW-67 V51042 JW-67 442644-28-2 JW67 inhibits canonical Wnt signaling with a ring IC50 of 1.17 μM.
KY-02327 V51039 KY-02327 2093407-25-9 KY-02327 is a stable analog of KY-02061 and a potent Disheveled (Dvl)-CXXC5 responder.
KY1220 V23366 KY1220 292168-79-7 KY1220 works on the Wnt/β-catenin target, destabilizing β-catenin and Ras.
KYA1797K V23368 KYA1797K 1956356-56-1 KYA1797K is a potent and specific Wnt/β-catenin inhibitor (antagonist) with IC50 of 0.75 µM.
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