A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2434 | exo-IWR-1 | 1127442-87-8 | exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is used as a negative control of IWR-1 (V1351) which is apotenttankyrase inhibitor of the Wnt pathway with potential antitumor activity. |
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V4124 | Adavivint (SM04690) | 1467093-03-3 | Adavivint (formerly known as SM04690) is a novel, potent, specific/selective inhibitor ofcanonical Wnt signaling pathway with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter in SW480 colon cancer cells. |
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V3347 | AMBMP | 853220-52-7 | Decription: AMBMP (also known as BML-284; BML284) is a novel, potent and cell-permeable Wnt signaling activator with anti-inflammatory activity. |
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V10977 | AMBMP hydrochloride | 2095432-75-8 | BML-284 HCl is a potent cell-penetrating/penetrable Wnt signaling activator. |
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V17578 | Cardiogenol C HCl | 1049741-55-0 | Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 of 0.1 µM. |
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V5055 | CCT-251545 | 1661839-45-7 | CCT251545 is a novel, potent, selective and orally bioavailable small-molecule inhibitor of WNT signaling with an IC50of 5 nM in 7dF3 cells. |
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V4879 | HLY78 | 854847-61-3 | HLY78 is a novel and potent small molecule activator of theWnt/β-cateninsignaling pathway which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. |
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V5249 | iCRT14 | 677331-12-3 | iCRT 14 is a novel and potent inhibitor of β-catenin-responsive transcription (CRT) with IC50of 40.3 nM against Wnt responsive STF16 luciferase in a homogeneous fluorescence polarization (FP) assay. |
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V3194 | iCRT3 | 901751-47-1 | iCRT3 (iCRT-3) is an inhibitor of Wnt and β-catenin-responsive transcription in the Wnt/wingless signaling pathway with anticancer activity. |
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V22784 | IWP-3 | 687561-60-0 | IWP-3 is a potent inhibitor of Wnt production with IC50 of 40 nM. |
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V22785 | IWP-4 | 686772-17-8 | IWP-4 is a small molecule Wnt inhibitor (antagonist) with IC50 of 25 nM. |
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V51042 | JW-67 | 442644-28-2 | JW67 inhibits canonical Wnt signaling with a ring IC50 of 1.17 μM. |
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V51039 | KY-02327 | 2093407-25-9 | KY-02327 is a stable analog of KY-02061 and a potent Disheveled (Dvl)-CXXC5 responder. |
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V23366 | KY1220 | 292168-79-7 | KY1220 works on the Wnt/β-catenin target, destabilizing β-catenin and Ras. |
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V23368 | KYA1797K | 1956356-56-1 | KYA1797K is a potent and specific Wnt/β-catenin inhibitor (antagonist) with IC50 of 0.75 µM. |
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V26036 | MSAB | 173436-66-3 | MSAB is a novel and potent inhibitor of Wnt/β-catenin signaling withanticancer activity. |
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V51041 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | 883715-23-9 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide extracted from Maca (Lepidium meyenii Walp). |
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V3200 | NCB-0846 | 1792999-26-8 | NCB-0846 (NCB0846) is a novel, first orally bioavailable small molecule inhibitor of Wntthat inhibitsTNIK (TRAF2 and NCK-Interacting Kinase)with IC50 value of 21 nM. |
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V27702 | PNU-74654 | 113906-27-7 | PNU-74654 (PNU74654) is a novel inhibitor of Wnt/β-catenin pathway (IC50 = 129.8 μM), acting byinhibiting the interaction between ß-catenin and T cell factor 4 (Tcf4), and disrupting the Wnt signaling pathway. |
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V2690 | PRI-724 | 1422253-38-0 | PRI-724 (an analog of ICG 001 and a prodrug of C-82)is a novel, potent an specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. |
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