Dopamine β-hydroxylase (also known as dopamine beta-hydroxylase or dopamine beta-monooxygenase) is an enzyme that is encoded by the DBH gene in humans. Noradrenaline, dehydroascorbate, and water are the three end products of the chemical reaction that dopamine β-monooxygenase catalyzes with the three substrates 3,4-dihydroxyphenethylamine, ascorbate, and oxygen. The oxidoreductase family, specifically those acting on paired donors with O2 as the oxidant and incorporation or reduction of oxygen, includes dopamine β-hydroxylase.
Tyrosine metabolism is aided by dopamine β-hydroxylase. Copper, PQQ, and fumarate are the three cofactors of dopamine β-hydroxylase. The pathway for the biosynthesis of catecholamines includes dopamine β-hydroxylase. The decision-making process, addictive behaviors like alcohol and smoking, attention deficit hyperactivity disorder, as well as neurological diseases like schizophrenia and Alzheimer's disease have all been linked to dopamine β-hydroxylase.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V125285 | 3-Allylphenol | 1446-24-8 | 3-Allylphenol is an inhibitor of dopamine β-hydroxylase with a Ki value of 12 mM. |
|
V73082 | Fusaric acid | 536-69-6 | Fusaric acid is a potent dopamine β-hydroxylase inhibitor. |
|
V114601 | SKF-102698 | 95333-81-6 | SKF-102698 is a dopamine β-hydroxylase inhibitor. |
|
V146704 | U-11634 | 3414-47-9 | U-11634 is an orally effective, non-competitive dopamine β-hydroxylase inhibitor. The subcutaneous LD50 value in rats is 1197 mg/kg, and the oral LD50 value is 524 mg/kg. |
|
V101401 | U-14624 | 14901-16-7 | U-14624 is a potent dopamine β-hydroxylase inhibitor. |
|
V3357 | Guanoclor | 5001-32-1 | Guanoclor, also known as guanochlor, is a sympatholytic drug with antihypertensive activity. |
|
V28456 | Zamicastat (BIA 5-1058) | 1080028-80-3 | Zamicastat is a potent and selective dopamine β-mono-oxygenase inhibitor. |
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