Gli proteins, which are the Hedgehog (Hh) signaling's effectors, have been found to be important for cell proliferation, patterning, and cell fate determination in many different cell types and the majority of organs during embryonic development. The Gli transcription factors interact with the transcription complex and bind to Gli responsive genes to activate or inhibit transcription. The DNA-binding zinc finger domains of the Gli transcription factors bind to consensus sequences on their target genes to either start or stop transcription. Its function as a transcription factor was demonstrated by research that revealed the effect of the protein was inhibited when the Gli zinc finger domain was altered. The 18-amino acid activation domain of the -helical herpes simplex viral protein 16 is strikingly similar to the region found in gli proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V5154 | GANT58 (NSC 75503) | 64048-12-0 | GANT 58(NSC 75503), atetrapyridinylthiophene compound, is a novel,cell-permeable and potent Gli antagonist that inhibits GLI1-induced transcription with IC50of 5 μM. |
|
V69838 | Glabrescione B | 65893-94-9 | Glabrescione B is the first compound to bind to the Hedgehog (Hh) regulator Gli1 and impair its activity by interfering with Gli1-DNA interactions. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
