Neprilysin (NEP) is a type II membrane metalloendopeptidase with about 750 residues, and its extracellular carboxyl terminal domain houses the zinc-binding motif (HEXXH) in the active site. Neprilysin has the ability to break down both the oligomeric and monomeric forms of the A peptide. The main A-peptide-degrading enzyme in the brain is called neprilysin, and both aging and Alzheimer's disease (AD) cause neprilysin to become inactive and down-regulated.
Neutral endopeptidase neprilysin increases the bioavailability of substance P, bradykinin, and natriuretic peptides, which has natriuretic, vasodilatory, and anti-proliferative effects.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V117167 | BL-2401 | 151774-56-0 | BL-2401 is an orally effective enkephalinase inhibitor. |
|
V116995 | CGS-30440 | 169319-62-4 | CGS-30440 is a potent, orally active dual inhibitor that simultaneously inhibits neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). |
|
V115926 | GW 796406 | 581096-47-1 | GW 796406 is a novel angiopeptidase inhibitor. |
|
V93687 | JA2 | 277333-45-6 | JA2 is an inhibitor of metalloendopeptidase 24.15 and enhances the hypotensive response to bradykinin in rats. |
|
V73277 | Opiorphin | 864084-88-8 | Opiorphin is an opioid peptide and a potent inhibitor of human enkephalin-inactivated zinc isopeptidase. |
|
V73276 | Racecadotril-d5 (Acetorphan-d5) | 1246815-11-1 | Racecadotril-d5 is the deuterium labelled form of Racecadotril. |
|
V114638 | RB-105 | 155895-89-9 | RB-105 is an angiotensin-converting enzyme (ACE) inhibitor (Ki = 4.2 nM) and a neutral endopeptidase (NEP) inhibitor (Ki = 1.7 nM). |
|
V73275 | Sacubitril-d4 (AHU-377-d4) | 1884269-07-1 | Sacubitril-d4 is the deuterium labelled form of Sacubitril. |
|
V73274 | Thiorphan-d7 | 1276297-68-7 | Thiorphan-d7 is the deuterium labelled form of Thiorphan. |
|
V115002 | Z-13752A | 193420-09-6 | Z-13752A is a mercaptopropionyl amino acid. |
|
V4541 | Sacubitril sodium | 149690-05-1 | Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril,is an NEP (neutral endopeptidase 24.11)inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan). |
![沙库必曲[AHU-377]](http://www.invivochem.com/upload/0201/CgAH513HkfCAcdi8AAAR8jQGFtk971.png)
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V4539 | Sacubitril (AHU-377) | 149709-62-6 | Sacubitril (formerly known as AHU-377; Entresto) is a novel and potentNEP (neutral endopeptidase 24.11)inhibitor used in combination with valsartan (as LCZ696) for heart failure. |
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