Neprilysin (NEP) is a type II membrane metalloendopeptidase with about 750 residues, and its extracellular carboxyl terminal domain houses the zinc-binding motif (HEXXH) in the active site. Neprilysin has the ability to break down both the oligomeric and monomeric forms of the A peptide. The main A-peptide-degrading enzyme in the brain is called neprilysin, and both aging and Alzheimer's disease (AD) cause neprilysin to become inactive and down-regulated.
Neutral endopeptidase neprilysin increases the bioavailability of substance P, bradykinin, and natriuretic peptides, which has natriuretic, vasodilatory, and anti-proliferative effects.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73277 | Opiorphin | 864084-88-8 | Opiorphin is an opioid peptide and a potent inhibitor of human enkephalin-inactivated zinc isopeptidase. |
|
V73276 | Racecadotril-d5 (Acetorphan-d5) | 1246815-11-1 | Racecadotril-d5 is the deuterium labelled form of Racecadotril. |
|
V4539 | Sacubitril (AHU-377) | 149709-62-6 | Sacubitril (formerly known as AHU-377; Entresto) is a novel and potentNEP (neutral endopeptidase 24.11)inhibitor used in combination with valsartan (as LCZ696) for heart failure. |
|
V4541 | Sacubitril sodium | 149690-05-1 | Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril,is an NEP (neutral endopeptidase 24.11)inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan). |
|
V73275 | Sacubitril-d4 (AHU-377-d4) | 1884269-07-1 | Sacubitril-d4 is the deuterium labelled form of Sacubitril. |
|
V73274 | Thiorphan-d7 | 1276297-68-7 | Thiorphan-d7 is the deuterium labelled form of Thiorphan. |
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