Neprilysin (NEP) is a type II membrane metalloendopeptidase with about 750 residues, and its extracellular carboxyl terminal domain houses the zinc-binding motif (HEXXH) in the active site. Neprilysin has the ability to break down both the oligomeric and monomeric forms of the A peptide. The main A-peptide-degrading enzyme in the brain is called neprilysin, and both aging and Alzheimer's disease (AD) cause neprilysin to become inactive and down-regulated.
Neutral endopeptidase neprilysin increases the bioavailability of substance P, bradykinin, and natriuretic peptides, which has natriuretic, vasodilatory, and anti-proliferative effects.
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