Neprilysin

Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase with about 750 residues, and its extracellular carboxyl terminal domain houses the zinc-binding motif (HEXXH) in the active site. Neprilysin has the ability to break down both the oligomeric and monomeric forms of the A peptide. The main A-peptide-degrading enzyme in the brain is called neprilysin, and both aging and Alzheimer's disease (AD) cause neprilysin to become inactive and down-regulated.

Neutral endopeptidase neprilysin increases the bioavailability of substance P, bradykinin, and natriuretic peptides, which has natriuretic, vasodilatory, and anti-proliferative effects.

Neprilysin related products

Structure Cat No. Product Name CAS No. Product Description
V73277 Opiorphin 864084-88-8
V73276 Racecadotril-d5 (Acetorphan-d5) 1246815-11-1
V4539 Sacubitril (AHU-377) 149709-62-6 Sacubitril (formerly known as AHU-377; Entresto) is a novel and potentNEP (neutral endopeptidase 24.11)inhibitor used in combination with valsartan (as LCZ696) for heart failure.
V4541 Sacubitril sodium 149690-05-1 Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril,is an NEP (neutral endopeptidase 24.11)inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan).
V73275 Sacubitril-d4 (AHU-377-d4) 1884269-07-1
V73274 Thiorphan-d7 1276297-68-7
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