Bcl-2

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Bcl-2

A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.

Bcl-2 related products

Cat No.	Product Name	CAS No.	Product Description
V28844	10-Deacetyl-7-xylosyl paclitaxel	90332-63-1	10-Deacetyl-7-xylosyl paclitaxel, a Paclitaxel analog, is ametabolite of Paclitaxel (TAXOL) which is a microtubule stabilizing agent/tubulin inhibitor and chemotherapeutic drug approved to treat various cancers.
V0010	A-1210477	1668553-26-1	A-1210477 is anovel, potent and specific MCL-1 (Myeloid cell leukemia-1) inhibitor with Ki and IC50 of 0.45 nM and 26.2 nM, respectively.
V76047	ABBV-467	2287186-66-5	ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM).
V0002	ABT-737	852808-04-9	ABT-737 is a novel, potent,selective and orally bioavailable BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in enzymatic assays, respectively.
V3448	AMG-176	1883727-34-1	AMG-176 (AMG176; tapotoclax) is a novel, potent, selective and orally bioavailable inhibitor of MCL-1 (myeloid cell leukemia-1) with aKiof 0.13 nM.
V0006	AT101	866541-93-7	AT-101 [(R)-(-)-Gossypol acetic acid,the levorotatory isomer of a natural product Gossypol],is a novel, oral and potent inhibitor of Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; it shows no inhibition against BIR3 and BID.
V4341	AZD-5991	2143061-81-6	AZD-5991 (AZD5991) is a novel, potent,rationally designed macrocyclic molecule and selectiveMCL-1inhibitor with anticancer activity.
V4342	AZD-5991 RACEMATE	2143010-83-5	AZD-5991 Racemate is the racemate of AZD-5991.
V4260	AZD4320	1357576-48-7	AZD4320 is a novel, potent BH3-mimic and dualinhibitor of BCL2/BCLxL withIC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.
V78336	BAD (103-127) (human), FAM-labeled		BAD (103-127) (human), FAM-labeled is FAM-labeled human BAD (103-127).
V5240	BAI1 (Bax channel blocker)	335165-68-9	BAI1 is a novel, potent and direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.
V78338	Bak BH3 (72-87), TAMRA-labeled		Bak BH3 (72-87), TAMRA-labeled is a biologically active peptide.
V8454	BAM 7	331244-89-4	BAM 7 is a Bax activator (EC50 = 3.3 μM).
V76046	Bcl-2-IN-12	1383737-59-4	Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC50= 6 nM).
V76045	Bcl-2-IN-13	1421687-31-1	Bcl-2-IN-13 is a Bcl-2 inhibitor (antagonist) with IC50 of 17 nM.
V78356	Bcl-2-IN-15		Bcl-2-IN-15 (Compound 13d)) is a Bcl-2 inhibitor (IC50= 363 nM).
V12602	BH3I-1	300817-68-9	BH3I-1 is a Bcl-2 family antagonist that can inhibit/disrupts the binding of Bak BH3 peptide to Bcl-xL with Ki of 2.4±0.2 μM.
V78418	Bid BH3 (80-99), FAM labeled		Bid BH3 (80-99), FAM labeled is a biologically active peptide.
V76044	Bim BH3, Peptide IV	721885-31-0	Bim BH3, Peptide IV is a 26-residue peptide extracted from the BH3-only protein Bim, which belongs to the pro-apoptotic family of Bcl-2 proteins.
V78422	Bim BH3, Peptide IV TFA		Bim BH3, Peptide IV TFA is a 26-residue peptide extracted from the BH3-only protein Bim, which belongs to the pro-apoptotic family of Bcl-2 proteins.