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Bcl-2

Bcl-2

A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.

Bcl-2 related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-BDA-366 V85121 (Rac)-BDA-366 142645-19-0
(Rac)-Lisaftoclax ((Rac)-APG-2575) V86177 (Rac)-Lisaftoclax ((Rac)-APG-2575) 2651980-10-6
(S)-Sabutoclax ((S)-BI-97C1) V85889 (S)-Sabutoclax ((S)-BI-97C1) 1228178-73-1
10-Deacetyl-7-xylosyl paclitaxel V28844 10-Deacetyl-7-xylosyl paclitaxel 90332-63-1 10-Deacetyl-7-xylosyl paclitaxel, a Paclitaxel analog, is ametabolite of Paclitaxel (TAXOL) which is a microtubule stabilizing agent/tubulin inhibitor and chemotherapeutic drug approved to treat various cancers.
A-1210477 V0010 A-1210477 1668553-26-1 A-1210477 is anovel, potent and specific MCL-1 (Myeloid cell leukemia-1) inhibitor with Ki and IC50 of 0.45 nM and 26.2 nM, respectively.
ABBV-467 V76047 ABBV-467 2287186-66-5 ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM).
ABT-737 V0002 ABT-737 852808-04-9 ABT-737 is a novel, potent,selective and orally bioavailable BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in enzymatic assays, respectively.
AMG-176 V3448 AMG-176 1883727-34-1 AMG-176 (AMG176; tapotoclax) is a novel, potent, selective and orally bioavailable inhibitor of MCL-1 (myeloid cell leukemia-1) with aKiof 0.13 nM.
AT101 V0006 AT101 866541-93-7 AT-101 [(R)-(-)-Gossypol acetic acid,the levorotatory isomer of a natural product Gossypol],is a novel, oral and potent inhibitor of Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; it shows no inhibition against BIR3 and BID.
AZD-5991 V4341 AZD-5991 2143061-81-6 AZD-5991 (AZD5991) is a novel, potent,rationally designed macrocyclic molecule and selectiveMCL-1inhibitor with anticancer activity.
AZD-5991 RACEMATE V4342 AZD-5991 RACEMATE 2143010-83-5 AZD-5991 Racemate is the racemate of AZD-5991.
AZD4320 V4260 AZD4320 1357576-48-7 AZD4320 is a novel, potent BH3-mimic and dualinhibitor of BCL2/BCLxL withIC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.
BAD (103-127) (human), FAM-labeled V78336 BAD (103-127) (human), FAM-labeled BAD (103-127) (human), FAM-labeled is FAM-labeled human BAD (103-127).
BAI1 (Bax channel blocker) V5240 BAI1 (Bax channel blocker) 335165-68-9 BAI1 is a novel, potent and direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.
Bak BH3 (72-87), TAMRA-labeled V78338 Bak BH3 (72-87), TAMRA-labeled Bak BH3 (72-87), TAMRA-labeled is a biologically active peptide.
BAM 7 V8454 BAM 7 331244-89-4 BAM 7 is a Bax activator (EC50 = 3.3 μM).
Bcl-2-IN-12 V76046 Bcl-2-IN-12 1383737-59-4 Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC50= 6 nM).
Bcl-2-IN-13 V76045 Bcl-2-IN-13 1421687-31-1 Bcl-2-IN-13 is a Bcl-2 inhibitor (antagonist) with IC50 of 17 nM.
Bcl-2-IN-15 V78356 Bcl-2-IN-15 Bcl-2-IN-15 (Compound 13d)) is a Bcl-2 inhibitor (IC50= 363 nM).
Bcl-2-IN-17 V86104 Bcl-2-IN-17 1321801-22-2
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