A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V0006 | AT101 | 866541-93-7 | AT-101 [(R)-(-)-Gossypol acetic acid,the levorotatory isomer of a natural product Gossypol],is a novel, oral and potent inhibitor of Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; it shows no inhibition against BIR3 and BID. |
|
V85121 | (Rac)-BDA-366 | 142645-19-0 | |
|
V86177 | (Rac)-Lisaftoclax ((Rac)-APG-2575) | 2651980-10-6 | |
|
V85889 | (S)-Sabutoclax ((S)-BI-97C1) | 1228178-73-1 | |
|
V88439 | 4-(4-Fluorophenyl)benzoic acid | 5731-10-2 | 4-(4-Fluorophenyl)benzoic acid (Compound 6) can bind to Bcl-2 with a KD value of 400 μM. |
|
V28844 | 10-Deacetyl-7-xylosyl paclitaxel | 90332-63-1 | 10-Deacetyl-7-xylosyl paclitaxel, a Paclitaxel analog, is ametabolite of Paclitaxel (TAXOL) which is a microtubule stabilizing agent/tubulin inhibitor and chemotherapeutic drug approved to treat various cancers. |
|
V0010 | A-1210477 | 1668553-26-1 | A-1210477 is anovel, potent and specific MCL-1 (Myeloid cell leukemia-1) inhibitor with Ki and IC50 of 0.45 nM and 26.2 nM, respectively. |
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V76047 | ABBV-467 | 2287186-66-5 | ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). |
|
V0002 | ABT-737 | 852808-04-9 | ABT-737 is a novel, potent,selective and orally bioavailable BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in enzymatic assays, respectively. |
|
V3448 | AMG-176 | 1883727-34-1 | AMG-176 (AMG176; tapotoclax) is a novel, potent, selective and orally bioavailable inhibitor of MCL-1 (myeloid cell leukemia-1) with aKiof 0.13 nM. |
|
V88447 | Anticancer agent 201 | Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range against a variety of tumor cell lines. | |
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V88440 | Apoptosis inducer 19 | Apoptosis inducer 19 (Compound 7g) is an apoptosis inducer. | |
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V87056 | Artobiloxanthone | Artobiloxanthone (Compound AA3) has antitumor activity, particularly against oral squamous cell carcinoma (OSCC). | |
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V4341 | AZD-5991 | 2143061-81-6 | AZD-5991 (AZD5991) is a novel, potent,rationally designed macrocyclic molecule and selectiveMCL-1inhibitor with anticancer activity. |
|
V4342 | AZD-5991 RACEMATE | 2143010-83-5 | AZD-5991 Racemate is the racemate of AZD-5991. |
|
V4260 | AZD4320 | 1357576-48-7 | AZD4320 is a novel, potent BH3-mimic and dualinhibitor of BCL2/BCLxL withIC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. |
|
V78336 | BAD (103-127) (human), FAM-labeled | BAD (103-127) (human), FAM-labeled is FAM-labeled human BAD (103-127). | |
|
V5240 | BAI1 (Bax channel blocker) | 335165-68-9 | BAI1 is a novel, potent and direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM. |
|
V78338 | Bak BH3 (72-87), TAMRA-labeled | Bak BH3 (72-87), TAMRA-labeled is a biologically active peptide. | |
|
V8454 | BAM 7 | 331244-89-4 | BAM 7 is a Bax activator (EC50 = 3.3 μM). |
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