LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases.There are two homologues in the LIMK family, LIMK1 and LIMK2, and they are distinct from one another in terms of expression pattern, intercellular localization, and function. Cofilin, a protein belonging to the actin-depolymerizing factor (ADF) protein family, is the main substrate of LIMK. Cofilin becomes inactive when it has been phosphorylated by LIMK. LIMKs contribute to the growth and metastasis of cancer as well as a number of neurodevelopmental disorders.
LIM domain kinases (LIMK1 and 2) phosphorylate cofilin at serine-3 to control actin dynamics and are substrates for Cdc42/Rac-PAK. The actin severing and depolymerizing activity of cofilin is rendered inactive by this modification. LIMKs control cell cycle progression by translocating into the nucleus. Potentially effective therapeutic targets for merlin-deficient tumors like NF2 include LIMKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75994 | 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide | 956707-04-3 | 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3) is a sesquiterpene with anti-LIMK1 activity. |
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V2986 | BMS-3 | 1338247-30-5 | BMS-3 is a potent inhibitor of the LIM kinase (LIMK)with IC50 of 5nM and 6 nM for LIMK1 and LIMK2 respectively. |
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V2987 | BMS-5 | 1338247-35-0 | BMS-5, also known as LIMKI-3, isan analog of BMS-3and potent inhibitor of the LIM kinase (LIMK) with IC50 values of 7 and 8 nM for LIMK1 and LIMK2 respectively. |
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V54751 | Curcolonol | 217817-09-9 | Curcolonol is a furan-type sesquiterpene. |
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V88692 | LIMK-IN-2 | 2747216-27-7 | LIMK-IN-2 (Compound 52) is a LIMK inhibitor. |
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V51858 | LIMK1 inhibitor BMS-4 | 905298-84-2 | LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor that targets LIMK1/2. |
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V31728 | R-10015 | 2097938-51-5 | R-10015 is a broad-spectrum antiviral compound that treats HIV infection. It binds to the ATP-binding pocket and inhibits LIM domain kinase (LIMK) with a potent and selective manner, with an IC50 of 38 nM for human LIMK1. |
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V81344 | S3 Fragments | S3 Fragment is a biologically active peptide. | |
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V3238 | T56-LIMKi (T5601640) | 924473-59-6 | T56-LIMKi (also known as T5601640) is a potent and selective inhibitor of LIMK2 (LIM kinase 2) with an IC50 of 35.2 μM in a cell (Panc-1 cells) assay. |
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V1133 | TH257 | 2244678-29-1 | TH257 (TH-257; TH 257) is a novel and selective allosteric inhibitor of LIM kinases-LIMK1 and LIMK2 with important biological activity. |
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V35206 | TH470 | 2834739-51-2 | TH470 is a selective LIMK1/2 (LIM kinase 1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), which can be used for orphan disease study. |
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