PI3K

PI3K

PI3K (Phosphoinositide 3-kinase), via phosphorylation of the inositol lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), forms the second messenger molecule phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) which recruits and activates pleckstrin homology domain containing proteins, leading to downstream signalling events crucial for proliferation, survival and migration. The four distinct catalytic isoforms of class I PI3K enzymes are PI3K, PI3K, PI3K, and PI3K.
Three main classes of PI3K enzymes exist, with class IA being strongly linked to cancer. Catalytic subunits (p110α, p110β, or p110δ; encoded by PIK3CA, PIK3CB, and PIK3CD genes, respectively) and regulatory subunits (p85) make up heterodimeric lipid kinases known as class IA PI3K.

The PI3K pathway is crucial for the progression of the cell cycle, cell growth and survival, actin rearrangement and migration, and intracellular vesicular transport, among many other biological processes.

PI3K related products

Structure Cat No. Product Name CAS No. Product Description
V70263 (S)-PI3Kα-IN-4 2322293-84-3
V0117 3-Methyladenine (3-MA; Autophagy Inhibitor) 5142-23-4 3-Methyladenine (also called 3-MA; Autophagy Inhibitor) is a novel, potent,cell-permeable and selective PI3K inhibitor.
V2540 740 Y-P (PDGFR 740Y-P) 1236188-16-1 740 Y-P is a cell-permeable peptide acting as a phosphopeptide activator of PI3K.
V0118 A66 1166227-08-2 A66 is a novel, potent,reversible, ATP-competitive and highly selective p110α inhibitor with potential anticancer activity.
V4057 Acalisib (GS-9820) 870281-34-8 Acalisib (formerly known asCAL-120;GS-9820) isa novel, potent and highly selective inhibitor ofp110δ[the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K)] with anticancer activities.
V69227 Acetyl-Exenatide 305815-28-5
V0114 Alpelisib (BLY-719; Piqray; NVP-BYL719) 1217486-61-7 Alpelisib (formerly also known as BLY719; trade name: Piqray) is a novel, potent, newly approved, orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with antineoplastic activity.
V69213 Amdizalisib (HMPL-689) 1894229-05-0
V11021 AMG-511 1253573-53-3 AMG-511 is a potent and selective pan class I PI3K inhibitor exhibiting IC50 of 8, 11, 2, and 6 nM against the PI3K β, α, β, and ≤ isoforms respectively.
V0153 AMG319 (ACP-319) 1608125-21-8 AMG319 (also known as ACP319) is a novel, potent, selective, orally bioavailable small molecule inhibitor of PI3Kδ (phosphoinositide-3 kinase δ)with potential anticancer activity.
V78789 Anticancer agent 137
V0125 Apitolisib (GDC-0980, RG-7422, GNE-390) 1032754-93-0 Apitolisib (formerly also known as GDC0980, RG7422, GNE390) is a novel, potent, selective and orally bioavailable class I PI3K inhibitor with potential anticancer activity.
V69231 Apoptin-derived peptide 2232156-31-7
V2333 AS-041164 1146702-72-8 AS-041164 is a Potent and selective PI3Kγ inhibitor(IC50= 70 nM).
V0130 AS-252424 900515-16-4 AS-252424 is a novel, potent, orally bioactive and selective PI3Kγ inhibitor with potential anticancer activity.
V0134 AS-604850 648449-76-7 AS-604850 is a novel, potent, selective, and ATP-competitive inhibitor of PI3Kγ (phosphatidylinositol 3-kinase γ) with IC50 of 250 nM and aKi of 180 nM.
V0115 AS-605240 648450-29-7 AS-605240 is a novel, potent, orally bioactive andATP-competitiveinhibitor of PI3-kinase γ (PI3Kγ) with potential anti-inflammatory activity.
V2337 AS041164 6318-41-8 AS041164 is a novel and potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM)
V69215 ATM Inhibitor-3 2769140-52-3
V69210 ATM Inhibitor-4 2769140-74-9
Contact Us