Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The sense strand is broken down as the short dsRNA unwinds. With various protein components, the antisense strand forms the RNA-induced silencing complex (RISC). The target gene's mRNA is specifically complementary to the antisense strand that RISC retains. The target gene's mRNA can be cut and degraded by the nuclease activity of RISC, which can also stop the target gene from being expressed. Inhibition of mRNA translation is the result of incomplete complementarity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75255 | AB-729 sodium | 2826248-50-2 | AB-729 sodium is an siRNA that can inhibit viral replication and reduces HBV (hepatitis B virus) antigen through RNA interference (RNAi). |
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V103993 | Adenosine Kinase siRNA-1 | Adenosine kinase siRNA-1 is a small interfering RNA (siRNA) targeting adenosine kinase, which has a knockdown effect on adenosine kinase. | |
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V103994 | Adenosine Kinase siRNA-2 | Adenosine kinase siRNA-2 is a small interfering RNA targeting adenosine kinase messenger RNA. | |
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V103995 | Adenosine Kinase siRNA-3 | Adenosine kinase siRNA-3 is a small interfering RNA (siRNA) targeting adenosine kinase, which has a knockdown effect on adenosine kinase. | |
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V116627 | Adenosine-3',5'-bisphosphate ammonium solution (100mM) | Adenosine-3',5'-diphosphate is an XRN1 inhibitor (IC50 = 36 nM). | |
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V77237 | AS-Patisiran | AS-Patisiran is the antisense strand of Patisiran. | |
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V88319 | Asvasiran | 870094-26-1 | Asvasiran is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication. |
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V88320 | Asvasiran sodium | 1386946-83-3 | Asvasiran sodium is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication. |
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V75257 | ATU027 | 1415935-22-6 | ATU027 is an siRNA that silences PKN3 expression in vascular endothelium. |
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V78286 | ATU027 sodium | ATU027 sodium is an siRNA that silences PKN3 expression in vascular endothelium. | |
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V116414 | B23 sodium | Sodium B23 is a DNA aptamer that specifically binds to luteinizing hormone (LH). | |
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V71321 | Bamosiran (SYL040012) | 1337968-84-9 | Bamosiran is an siRNA targeting β-adrenergic receptor 2, used to reduce intraocular pressure |
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V78343 | Bamosiran sodium (SYL040012 sodium) | Bamosiran sodium is an siRNA targeting β-adrenergic receptor 2, used to reduce intraocular pressure | |
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V116417 | CD4 aptamer sodium | Sodium CD4 aptamer is a single-stranded DNA aptamer that targets CD4 and significantly inhibits the interaction between the viral gp120 and CD4-expressing cells. | |
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V120365 | CeMMEC1 hydrochloride | 2095432-53-2 | CeMMEC1 (hydrochloride) is an N-methylisoquinolinone derivative that inhibits the second bromine domain of TAF1, with an IC50 of 0.9 μM. |
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V110528 | CGN peptide TFA | CGN peptide TFA is a polypeptide composed of 13 amino acids, mainly composed of D-type amino acids, and is abbreviated as CGN peptide. | |
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V75256 | Cimdelirsen (ISIS 766720; IONIS-GHR-LRx) | 2131025-82-4 | Cimdelirsen is a liver-targeted antisense oligonucleotide that reduces growth hormone receptor (GHr) synthesis, thereby inhibiting the harmful effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor in patients with acromegaly. |
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V75254 | Cimdelirsen sodium (ISIS 766720 sodium; IONIS-GHR-LRx sodium) | 2131025-83-5 | Cimdelirsen (sodium) is a liver-targeted antisense oligonucleotide that reduces growth hormone receptor (GHr) synthesis, thereby inhibiting the deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin in patients with acromegaly. |
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V116401 | DTA-64 sodium | Sodium DTA-64 is a nucleic acid aptamer that targets DEK. | |
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V113704 | Elebsiran scramble negative control | The Elebsiran perturbation negative control is an Elebsiran sequence modified in the same way. |
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