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Small Interfering RNA (siRNA)

Small Interfering RNA (siRNA)

Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The sense strand is broken down as the short dsRNA unwinds. With various protein components, the antisense strand forms the RNA-induced silencing complex (RISC). The target gene's mRNA is specifically complementary to the antisense strand that RISC retains. The target gene's mRNA can be cut and degraded by the nuclease activity of RISC, which can also stop the target gene from being expressed. Inhibition of mRNA translation is the result of incomplete complementarity.

Small Interfering RNA (siRNA) related products

Structure Cat No. Product Name CAS No. Product Description
AB-729 sodium V75255 AB-729 sodium 2826248-50-2 AB-729 sodium is an siRNA that can inhibit viral replication and reduces HBV (hepatitis B virus) antigen through RNA interference (RNAi).
Adenosine Kinase siRNA-1 V103993 Adenosine Kinase siRNA-1 Adenosine kinase siRNA-1 is a small interfering RNA (siRNA) targeting adenosine kinase, which has a knockdown effect on adenosine kinase.
Adenosine Kinase siRNA-2 V103994 Adenosine Kinase siRNA-2 Adenosine kinase siRNA-2 is a small interfering RNA targeting adenosine kinase messenger RNA.
Adenosine Kinase siRNA-3 V103995 Adenosine Kinase siRNA-3 Adenosine kinase siRNA-3 is a small interfering RNA (siRNA) targeting adenosine kinase, which has a knockdown effect on adenosine kinase.
Adenosine-3',5'-bisphosphate V128313 Adenosine-3',5'-bisphosphate 1053-73-2 Adenosine-3',5'-bisphosphate is an inhibitor of the ribonuclease XRN1 with an IC50 of 36 nM, a KD of 12 nM, and a KD of 14 nM for human XRN2.
Adenosine-3',5'-bisphosphate ammonium solution (100mM) V116627 Adenosine-3',5'-bisphosphate ammonium solution (100mM) Adenosine-3',5'-diphosphate is an XRN1 inhibitor (IC50 = 36 nM).
AS-Patisiran V77237 AS-Patisiran AS-Patisiran is the antisense strand of Patisiran.
AS-Patisiran sodium V129524 AS-Patisiran sodium AS-Patisiran sodium is the antisense chain of Patisiran.
Asvasiran V88319 Asvasiran 870094-26-1 Asvasiran is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication.
Asvasiran sodium V88320 Asvasiran sodium 1386946-83-3 Asvasiran sodium is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication.
ATU027 V75257 ATU027 1415935-22-6 ATU027 is an siRNA that silences PKN3 expression in vascular endothelium.
ATU027 sodium V78286 ATU027 sodium ATU027 sodium is an siRNA that silences PKN3 expression in vascular endothelium.
ATU027 sodium scrambled negative control V129638 ATU027 sodium scrambled negative control The ATU027 sodium scrambled negative control is a negative control with the sequence of ATU027 sodium salt scrambled.
B23 sodium V116414 B23 sodium Sodium B23 is a DNA aptamer that specifically binds to luteinizing hormone (LH).
Bamosiran (SYL040012) V71321 Bamosiran (SYL040012) 1337968-84-9 Bamosiran is an siRNA targeting β-adrenergic receptor 2, used to reduce intraocular pressure
Bamosiran sodium (SYL040012 sodium) V78343 Bamosiran sodium (SYL040012 sodium) Bamosiran sodium is an siRNA targeting β-adrenergic receptor 2, used to reduce intraocular pressure
Bamosiran sodium scrambled negative control V129886 Bamosiran sodium scrambled negative control The scrambled negative control of bamosiran sodium is a negative control for bamosiran sodium with a scrambled sequence.
CD4 aptamer sodium V116417 CD4 aptamer sodium Sodium CD4 aptamer is a single-stranded DNA aptamer that targets CD4 and significantly inhibits the interaction between the viral gp120 and CD4-expressing cells.
CeMMEC1 hydrochloride V120365 CeMMEC1 hydrochloride 2095432-53-2 CeMMEC1 (hydrochloride) is an N-methylisoquinolinone derivative that inhibits the second bromine domain of TAF1, with an IC50 of 0.9 μM.
CGN peptide V131444 CGN peptide 2421211-40-5 CGN peptide is a D-amino acid peptide composed of 13 amino acids, also known as CGN peptide.
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