The gastrin-releasing peptide (GRPR) and neuromedin B (NMBR) receptors, as well as Bn receptor subtypes 3 (BRS-3) and 4 (BB4), are members of the bombesin (Bn) receptor family. The stimulation of gastrointestinal hormone release, activation of macrophages, and effects on development are just a few of the biological processes that are mediated by the activation of these receptors. These biological processes also include significant changes in the central nervous system, such as satiety, control of circadian rhythm, and thermoregulation. Bn-related peptides have strong growth-promoting properties that cause both normal cells and various tumor cell lines to proliferate.
BRS-3 is gaining more attention due to its role in several GI tract and central nervous system (CNS) processes as well as the fact that it belongs to one of the G-protein coupling receptor families that is most frequently overexpressed or ectopically expressed by a variety of tumors, including prostate, small cell lung, breast, and CNS tumors, as well as carcinoids (intestinal, thymic, and bronchial).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V77217 | BA 1 TFA | BA 1 TFA is a bombesin (BB) receptor family agonist. | |
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V4295 | MK-5046 | 1022152-70-0 | MK-5046 (MK5046) is a novel and potent Bombesin receptor subtype-3 (BRS-3) agonist with anti-obesity effect. |
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V4011 | ML18 | 1422269-30-4 | ML-18 (the S-enantiomer, the enantiomer is EMY-98), a nonpeptide analogs of PD176252, is a BRS-3 (Bombesin receptor subtype 3) antagonist with an IC50 of 4.8 μM. |
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