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Cathepsin

Cathepsin

Cathepsins are protease enzymes that can be divided into several families. Cathepsins come in serine, cysteine, or aspartyl protease varieties. Humans have cathepsins from about 15 different classes (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins perform a variety of tasks and are active in the lysosome's low pH environment. Similar to other enzymes, they are essential for a variety of physiological processes, including apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, metastasis, digestion, blood clotting, bone resorption, ion channel activity, innate immunity, complement activation, and a host of others.

Numerous pathologies, such as arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola, have been linked to the dysregulated cathepsins.

Cathepsin related products

Structure Cat No. Product Name CAS No. Product Description
3-表熊果酸 V28590 3-Epiursolic Acid 989-30-0 3-Epiursolic Acid is a triterpenoid that can be extracted from Eriobotrya japonica.
Ac-FR-AFC TFA V118417 Ac-FR-AFC TFA Ac-FR-AFC TFA is a fluorescent substrate for cathepsin L (excitation wavelength 400 nm, emission wavelength 505 nm).
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate V109007 Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate is a cathepsin D substrate that can be used for the detection of cathepsin D FRET.
Ac-RR-AFC TFA V118588 Ac-RR-AFC TFA Ac-RR-AFC TFA is a fluorescent substrate for detecting cathepsin B (excitation wavelength 400 nm, emission wavelength 505 nm).
Arg-Arg-AMC acetate V87355 Arg-Arg-AMC acetate Arg-Arg-AMC acetate is the acetate form of Arg-Arg-AMC.
BI-9740 V117724 BI-9740 1628596-25-7 BI-9740 is an orally effective selective cathepsin C (CatC) inhibitor with an IC50 of 0.6 nM in mice and 2.6 nM in rats.
Bz-FVR-AMC TFA V87360 Bz-FVR-AMC TFA Bz-FVR-AMC TFA is a fluorescent substrate for cathepsin with a kcat/Km value of 1070 mM-1s-1. High concentrations of BZ-FVR-AMC have an inhibitory effect on the substrate.
Cathepsin C-IN-6 V78655 Cathepsin C-IN-6 Cathepsin C-IN-6 (compound 2) is an E-64c-hydrazine-based cathepsin C (cathepsin C) inhibitor (antagonist) with anti-inflammatory activity.
Cathepsin C-IN-7 V109022 Cathepsin C-IN-7 77180-19-9 Cathepsin C-IN-7 (page 68) is a cathepsin C inhibitor.
Cathepsin D and E FRET Substrate acetate V77164 Cathepsin D and E FRET Substrate acetate Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsin D and E, not for B, H or I, and its cleavage occurs at the Phe-Phe amide bond.
Cathepsin D/E Substrate, Fluorogenic V78656 Cathepsin D/E Substrate, Fluorogenic Cathepsin D/E Substrate, Fluorogenic, an 11-amino acid (AA) peptide, is a selective substrate for cathepsins D and E.
Cathepsin G V85302 Cathepsin G 107200-92-0
Cathepsin H, human liver V83635 Cathepsin H, human liver 60748-73-4
Cathepsin Inhibitor 3 V78657 Cathepsin Inhibitor 3 3026372-49-3 Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in the radiosynthesis of compound [18F]2k and is selective for cathepsin S.
Cathepsin Inhibitor 4 V87359 Cathepsin Inhibitor 4 Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S with Ki of 0.04 nM.
Cathepsin K inhibitor 4 V77985 Cathepsin K inhibitor 4 Cathepsin K inhibitor 4 is a potent carbohydrazide cathepsin K inhibitor, with IC50s of 13 nM, 269 nM, and 296 nM for human, rat, and mouse cathepsin K respectively.
Cathepsin K inhibitor 7 V101025 Cathepsin K inhibitor 7 Cathepsin K inhibitor 7 (Compound 7) is a Cathepsin K inhibitor with a pKi value of 7.3 for CatK.
Cathepsin K-IN-8 V119350 Cathepsin K-IN-8 501126-27-8 Cathepsin K-IN-8 (Examples 6-60) is a cathepsin K inhibitor that can be used to study inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, and tumors.
Cathepsin K-IN-9 V110948 Cathepsin K-IN-9 2361420-28-0 Cathepsin K-IN-9 is a highly selective, efficient, and orally effective cathepsin K inhibitor with an IC50 value of 6.2 nM.
Cathepsin L-IN-3 V86253 Cathepsin L-IN-3 478164-48-6
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