Cathepsins are protease enzymes that can be divided into several families. Cathepsins come in serine, cysteine, or aspartyl protease varieties. Humans have cathepsins from about 15 different classes (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins perform a variety of tasks and are active in the lysosome's low pH environment. Similar to other enzymes, they are essential for a variety of physiological processes, including apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, metastasis, digestion, blood clotting, bone resorption, ion channel activity, innate immunity, complement activation, and a host of others.
Numerous pathologies, such as arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola, have been linked to the dysregulated cathepsins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V28590 | 3-Epiursolic Acid | 989-30-0 | 3-Epiursolic Acid is a triterpenoid that can be extracted from Eriobotrya japonica. |
|
V78655 | Cathepsin C-IN-6 | Cathepsin C-IN-6 (compound 2) is an E-64c-hydrazine-based cathepsin C (cathepsin C) inhibitor (antagonist) with anti-inflammatory activity. | |
|
V77164 | Cathepsin D and E FRET Substrate acetate | Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsin D and E, not for B, H or I, and its cleavage occurs at the Phe-Phe amide bond. | |
|
V78656 | Cathepsin D/E Substrate, Fluorogenic | Cathepsin D/E Substrate, Fluorogenic, an 11-amino acid (AA) peptide, is a selective substrate for cathepsins D and E. | |
|
V78657 | Cathepsin Inhibitor 3 | Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in the radiosynthesis of compound [18F]2k and is selective for cathepsin S. | |
|
V77985 | Cathepsin K inhibitor 4 | Cathepsin K inhibitor 4 is a potent carbohydrazide cathepsin K inhibitor, with IC50s of 13 nM, 269 nM, and 296 nM for human, rat, and mouse cathepsin K respectively. | |
|
V78658 | Cathepsin L/S-IN-1 | Cathepsin L/S-IN-1 is a dual (bifunctional) inhibitor of Cathepsin L and Cathepsin S with IC50 of 4.10 μM and 1.79 μM respectively. | |
|
V3413 | E-64 HCl | E-64 HCl, the hydrochloride salt form of E-64, which isisolated from cultures of Aspergillus, is anovel, potent,irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. | |
|
V76935 | Hepcidin-1 (mouse) (TFA) | Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. | |
|
V80558 | LN5P45 | LN5P45 is an OTUB2 inhibitor (IC50= 2.3 μM). | |
|
V4301 | MK-0674 | 887781-62-6 | MK-0674 is a novel, potent, orally bioavailable and selectivecathepsin Kinhibitor with anIC50of 0.4 nM. |
|
V76514 | SID 26681509 quarterhydrate | SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with IC50 of 56 nM. | |
|
V81635 | TSC25 | TSC25 is a potent inhibitor of cruzipain (CZP) with IC50 of 3.34 nM and pIC50 of 8.48. |
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