REV-ERB is one of two related proteins called REV-ERB and REV-ERB that make up the nuclear receptor superfamily. Circadian rhythms and metabolism are connected by REV-ERB and REV-ERB, which are encoded by Nr1d1 and Nr2 respectively. Because REV-ERBs lack the traditional NR activation domain, they have the ability to repress transcription. Similar to other NRs, REV-ERBs can be controlled by ligands, such as heme found in nature (22, 23), which modifies their repressive activity. The retinoic acid receptor-related orphan receptor (ROR) and two REV-ERB molecules, which are typically present as a dimer, compete for binding to the ROR response element DNA sequence (RORE) region. Numerous physiological processes, including immune response, metabolism, and circadian rhythm, are regulated by REV-ERB. In light of this, REV-ERB has been viewed as a promising yet challenging drug target for the treatment of many diseases.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V67780 | 16α-Hydroxytrametenolic acid | 176390-68-4 | 16α-Hydroxytrametenolic acid is a naturally occurring triterpene and a potential retinoid X receptor (RXR) agonist. |
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V67775 | 4-Hydroxyretinoic acid | 66592-72-1 | 4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoic acid analogue with multiple biological effects. |
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V67778 | AGN 192870 | 166977-57-7 | AGN 192870 is a RAR neutral antagonist (inhibitor) with Kds of 147, 33 and 42 nM for RARα, RARβ and RARγ respectively. |
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V67774 | HX600 | 172705-89-4 | HX600 is a synthetic agonist of the RXR (Retinoid X Receptor) heterodimer complex. |
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V67783 | KCL-286 | 1952276-71-9 | KCL-286 is an orally bioactive retinoic acid receptor (RAR/RXR) beta2 agonist with ameliorating effects on spinal cord injury (SCI). |
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V67785 | LG101506 | 331248-11-4 | LG101506 is a selective and orally bioactive RXR modulator with a Ki of 2.7 nM for RXRα. |
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V67776 | NBD-125 | 2367641-24-3 | NBD-125 (B-12) is an analog of berberine and an agonist of RXRα, with IC50 of 31.10 μM in KM12C cells. |
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V67777 | NEt-iFQ | 1251538-60-9 | NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. |
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V81431 | SR-29065 | SR-29065 is a selective REV-ERBα agonist for use in autoimmune disease study. | |
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V9544 | SR8278 | 1254944-66-5 | SR8278 (SR-8278; SR 8278) is a novel, potent, synthetic and competitiveRev-Erbα antagonist with the potential for treating Duchenne muscular dystrophy (DMD). |
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V4070 | SR9011 | 1379686-29-9 | SR9011 is a novel and potentsynthetic REV-ERBα/βagonist withIC50 values of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. |
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V67786 | SR9011 hydrochloride | 2070014-94-5 | SR9011 HCl is a REV-ERBα/β agonist for REV-ERBα and REV-ERBβ with IC50s of 790 nM and 560 nM respectively. |
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V67787 | STL1267 | 1429024-58-7 | STL1267 is a potent REV-ERB agonist that crosses the BBB (blood-brain barrier) with a Ki of 0.16 µM for REV-ERBα. |
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V67784 | XS-060 | 2787626-06-4 | XS-060 is a potent anti-cancer compound and RXRα antagonist. |
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V67781 | YCT529 | 2863670-67-9 | YCT529 is a potent, selective and orally bioactive RAR-α inhibitor. |
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V67779 | YCT529 free acid | 2863670-66-8 | YCT529 free acid is a potent, selective and orally bioactive RAR-α inhibitor. |