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REV-ERB

REV-ERB

REV-ERB is one of two related proteins called REV-ERB and REV-ERB that make up the nuclear receptor superfamily. Circadian rhythms and metabolism are connected by REV-ERB and REV-ERB, which are encoded by Nr1d1 and Nr2 respectively. Because REV-ERBs lack the traditional NR activation domain, they have the ability to repress transcription. Similar to other NRs, REV-ERBs can be controlled by ligands, such as heme found in nature (22, 23), which modifies their repressive activity. The retinoic acid receptor-related orphan receptor (ROR) and two REV-ERB molecules, which are typically present as a dimer, compete for binding to the ROR response element DNA sequence (RORE) region. Numerous physiological processes, including immune response, metabolism, and circadian rhythm, are regulated by REV-ERB. In light of this, REV-ERB has been viewed as a promising yet challenging drug target for the treatment of many diseases.

REV-ERB related products

Structure Cat No. Product Name CAS No. Product Description
V67780 16α-Hydroxytrametenolic acid 176390-68-4 16α-Hydroxytrametenolic acid is a naturally occurring triterpene and a potential retinoid X receptor (RXR) agonist.
V67775 4-Hydroxyretinoic acid 66592-72-1 4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoic acid analogue with multiple biological effects.
V67778 AGN 192870 166977-57-7 AGN 192870 is a RAR neutral antagonist (inhibitor) with Kds of 147, 33 and 42 nM for RARα, RARβ and RARγ respectively.
V67774 HX600 172705-89-4 HX600 is a synthetic agonist of the RXR (Retinoid X Receptor) heterodimer complex.
V67783 KCL-286 1952276-71-9 KCL-286 is an orally bioactive retinoic acid receptor (RAR/RXR) beta2 agonist with ameliorating effects on spinal cord injury (SCI).
V67785 LG101506 331248-11-4 LG101506 is a selective and orally bioactive RXR modulator with a Ki of 2.7 nM for RXRα.
V67776 NBD-125 2367641-24-3 NBD-125 (B-12) is an analog of berberine and an agonist of RXRα, with IC50 of 31.10 μM in KM12C cells.
V67777 NEt-iFQ 1251538-60-9 NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties.
V81431 SR-29065 SR-29065 is a selective REV-ERBα agonist for use in autoimmune disease study.
V9544 SR8278 1254944-66-5 SR8278 (SR-8278; SR 8278) is a novel, potent, synthetic and competitiveRev-Erbα antagonist with the potential for treating Duchenne muscular dystrophy (DMD).
V4070 SR9011 1379686-29-9 SR9011 is a novel and potentsynthetic REV-ERBα/βagonist withIC50 values of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
V67786 SR9011 hydrochloride 2070014-94-5 SR9011 HCl is a REV-ERBα/β agonist for REV-ERBα and REV-ERBβ with IC50s of 790 nM and 560 nM respectively.
V67787 STL1267 1429024-58-7 STL1267 is a potent REV-ERB agonist that crosses the BBB (blood-brain barrier) with a Ki of 0.16 µM for REV-ERBα.
V67784 XS-060 2787626-06-4 XS-060 is a potent anti-cancer compound and RXRα antagonist.
V67781 YCT529 2863670-67-9 YCT529 is a potent, selective and orally bioactive RAR-α inhibitor.
V67779 YCT529 free acid 2863670-66-8 YCT529 free acid is a potent, selective and orally bioactive RAR-α inhibitor.
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