TAM Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TAM Receptor

TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells.The mature immune, nervous, and reproductive systems depend on the TAM family of receptors and their ligands, Gas6 and Protein S (PROS1), for the best phagocytosis of apoptotic cells.

Three homologous type I receptor-tyrosine kinases known as TAMs are triggered by PROS1 and GAS6, two endogenous ligands. These ligands can either act as soluble factors to activate TAMs or act as connecting molecules between TAMs and apoptotic cells (ACs) by opsonizing phosphatidylserine (PS) on ACs. Cancer cell survival and proliferation as well as the suppression of anti-tumor immunity have been linked to abnormal TAM expression and activation.

TAM Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V69563	Anticancer agent 109	2097497-16-8	Anticancer agent 109 (compound 6-15) is an inhibitor (blocker/antagonist) of the Gas6-Axl axis and has tumor suppressor activity.
V69487	AXL-IN-13	2376928-82-2	AXL-IN-13 is a potent, orally bioactive AXL inhibitor (IC50= 1.6 nM, Kd: 0.26 nM).
V69569	AXL-IN-14	2947506-65-0	AXL-IN-14 is a potent orally bioactive AXL inhibitor (antagonist) with IC50 of 0.8 nM.
V69571	AXL-IN-15	1954722-22-5	AXL-IN-15 (cpd391) is a potent Axl inhibitor (antagonist) with Ki and IC50 <1 nM.
V84743	Axl-IN-17
V69572	Axl-IN-3	2783991-34-2	Axl-IN-3 is a specific, orally bioactive AXL kinase inhibitor (antagonist) with IC50 of 41.5 nM.
V69282	Axl/Mer/CSF1R-IN-1	2394874-60-1	Axl/Mer-IN-1 (Compound 1) is an inhibitor (blocker/antagonist) of Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R with Kds less than 0.1 μM.
V69280	Axl/Mer/CSF1R-IN-2	2394874-63-4	Axl/Mer/CSF1R-IN-2 (Comp 4) is an inhibitor (blocker/antagonist) of Axl, Mer and CSF1R.
V69570	AZ14145845	2830555-70-7	AZ14145845 is a selective Mer/Axl type I1/2 dual-specific kinase inhibitor (antagonist) with in vivo efficacy.
V69565	Batiraxcept (AVB-S6-500)	2268717-61-7	Batiraxcept (AVB-S6-500) is a potent and specific AXL inhibitor that is a recombinant fusion protein dimer containing the extracellular domain of human AXL and the human immunoglobulin G1 heavy chain (Fc).
V88082	BPR5K230	3029897-97-7	BPR5K230 is a dual inhibitor of receptor tyrosine kinases MER and AXL with IC50 of 4.1 nM and 9.2 nM, respectively.
V91785	ER-851	2685738-33-2	ER-851 is an orally active, selective AXL inhibitor with IC50 of 100 nM.
V0638	LDC1267	1361030-48-9	LDC1267 (LDC-1267) is a novel, highly potent and selective TAM (Tyro3, Axl and Mer) kinase inhibitor with potential antitumor activity.
V0595	NPS-1034	1221713-92-3	NPS-1034 (NPS1034; NPS 1034) is a novel, potent dual inhibitor of the tyrosine kinases Met and Axl with potential antineoplastic activity.
V3425	SGI-7079	1239875-86-5	SGI-7079 (SGI7079) is a novel, potent and selective Axl inhibitor with potential anti-inflammatory and anticancer activities.
V0636	UNC2250	1493694-70-4	UNC2250 (UNC-2250) is a novel, potent and selective Mer inhibitor with potential antitumor activity.
V0637	UNC2881	1493764-08-1	UNC2881 (UNC-2881) is a novel, potent and specific Mer tyrosine kinase inhibitor with potential utility for prevention and treatment of pathologic thrombosis.
V69566	UNC1062	1350549-36-8	UNC1062 is a MERTK-selective tyrosine kinase inhibitor that reduces the activation of MERTK-mediated downstream signaling, causes apoptosis in culture, reduces colony formation in soft agar, and inhibits melanoma cell invasion.
V69248	UNC5293	2226789-82-6	UNC5293 is a selective inhibitor of MERTK (Ki=190 pM).
V5018	UNC569	1350547-65-7	UNC569 is a novel, potent and selective small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.