TAM Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TAM Receptor

TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells.The mature immune, nervous, and reproductive systems depend on the TAM family of receptors and their ligands, Gas6 and Protein S (PROS1), for the best phagocytosis of apoptotic cells.

Three homologous type I receptor-tyrosine kinases known as TAMs are triggered by PROS1 and GAS6, two endogenous ligands. These ligands can either act as soluble factors to activate TAMs or act as connecting molecules between TAMs and apoptotic cells (ACs) by opsonizing phosphatidylserine (PS) on ACs. Cancer cell survival and proliferation as well as the suppression of anti-tumor immunity have been linked to abnormal TAM expression and activation.

TAM Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V102922	(Z)-S49076 hydrochloride	1265965-19-2	(Z)-S49076 hydrochloride is an oral MET and AXL inhibitor that blocks downstream signaling of these receptors in vivo and in vitro, inhibits tumor cell proliferation and migration, and suppresses tumor growth in xenograft models.
V69563	Anticancer agent 109	2097497-16-8	Anticancer agent 109 (compound 6-15) is an inhibitor (blocker/antagonist) of the Gas6-Axl axis and has tumor suppressor activity.
V69487	AXL-IN-13	2376928-82-2	AXL-IN-13 is a potent, orally bioactive AXL inhibitor (IC50= 1.6 nM, Kd: 0.26 nM).
V69569	AXL-IN-14	2947506-65-0	AXL-IN-14 is a potent orally bioactive AXL inhibitor (antagonist) with IC50 of 0.8 nM.
V69571	AXL-IN-15	1954722-22-5	AXL-IN-15 (cpd391) is a potent Axl inhibitor (antagonist) with Ki and IC50 <1 nM.
V84743	Axl-IN-17
V129702	Axl-IN-19	2870696-46-9	Axl-IN-19 is a selective AXL (a membrane-bound receptor tyrosine kinase) inhibitor (IC50: 5.3 nM; cellular KD = 6.8 nM).
V115582	Axl-IN-20	2487649-59-0	Axl-IN-20 (compound w11) is a selective, orally effective AXL inhibitor with an IC50 of 5 nM.
V111065	Axl-IN-21	1958081-87-2	Axl-IN-21 is an orally effective selective AXL inhibitor with a Kd value of 2.7 nM and an IC50 value of 4.0 nM.
V69572	Axl-IN-3	2783991-34-2	Axl-IN-3 is a specific, orally bioactive AXL kinase inhibitor (antagonist) with IC50 of 41.5 nM.
V69282	Axl/Mer/CSF1R-IN-1	2394874-60-1	Axl/Mer-IN-1 (Compound 1) is an inhibitor (blocker/antagonist) of Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R with Kds less than 0.1 μM.
V69280	Axl/Mer/CSF1R-IN-2	2394874-63-4	Axl/Mer/CSF1R-IN-2 (Comp 4) is an inhibitor (blocker/antagonist) of Axl, Mer and CSF1R.
V69570	AZ14145845	2830555-70-7	AZ14145845 is a selective Mer/Axl type I1/2 dual-specific kinase inhibitor (antagonist) with in vivo efficacy.
V69565	Batiraxcept (AVB-S6-500)	2268717-61-7	Batiraxcept (AVB-S6-500) is a potent and specific AXL inhibitor that is a recombinant fusion protein dimer containing the extracellular domain of human AXL and the human immunoglobulin G1 heavy chain (Fc).
V112391	Bemcentinib-d8		Bemcentinib-d8 (R428-d8) is the deuterated version of bemcentinib.
V88082	BPR5K230	3029897-97-7	BPR5K230 is a dual inhibitor of receptor tyrosine kinases MER and AXL with IC50 of 4.1 nM and 9.2 nM, respectively.
V131971	C-Met/Axl-IN-1		C-Met/Axl-IN-1 is an orally effective selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively.
V107111	Denfivontinib hydrochloride	1457983-33-3	Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab.
V135073	Enapotamab vedotin	1912424-97-5	Enapotamab vedotin is an antibody-drug conjugate (ADC) that targets AXL and has an inhibitory effect on non-small cell lung cancer (NSCLC) with high AXL expression.
V91785	ER-851	2685738-33-2	ER-851 is an orally active, selective AXL inhibitor with IC50 of 100 nM.