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ULK

ULK

The ULK (UNC51-like) enzymes are a family of mammalian kinases that have critical roles in autophagy and development. ULK1 through ULK4 and STK36 are the 5 genes that make up the ULK family of kinases in mammals. It has been established that ULK1 and ULK2 play important roles in a variety of pathological, physiological, and developmental processes in mammals and are required for the proper induction of autophagy.

Serine/threonine protein kinases ULK1 and ULK2, which play redundant roles in the control of autophagy, are evolutionarily conserved orthologs of the yeast member of the Atg (autophagy related) family Atg1. Long-lived proteins or organelles are the targets of autophagy, which degrades them in lysosomes before recycling the byproducts for use in other cellular pathways. The four components of the RB1CC1/FIP200/ATG17, ULK1, ATG13, and ATG101 make up the canonical ULK/ATG1 complex.
By phosphorylating certain enzymes in the class III phosphatidylinositol 3-kinase complex (such as PI3K3C/Vps34, PIK3R4/Vps15, BECN1/Vps30/ATG6, ATG14), it helps to start the formation of autophagosomes, at least in part. Through ATG9, ULK/Atg1 also encourages membrane recycling. Mice lacking both ULK1 and ULK2 expression die soon after birth due to a defect in glycogen metabolism, similar to other autophagy-defective mice, which is consistent with the known role of ULK1/2 in autophagy. Disrupting ULK1 expression also causes a defect in the autophagy-mediated clearance of mitochondria during red blood cell maturation in mice.

ULK related products

Structure Cat No. Product Name CAS No. Product Description
BL-918 V5203 BL-918 2101517-69-3 BL-918, a racemic mixture, is a novel and potent small molecule activator of UNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinson’s disease treatment.
LYN-1604 V3195 LYN-1604 2088939-99-3 LYN-1604 (LYN1604) is a potent agonist or activator of the UNC-51-like kinase 1 (ULK1) with potential antitumor activity.
LYN-1604 HCl V3196 LYN-1604 HCl 2216753-86-3 LYN-1604 HCl, the hydrochloride salt ofLYN-1604, is a novel and potent activator/agonist of the UNC-51-like kinase 1 (ULK1) (EC50= 18.94 nM) with anticancer activity.
MRT-68921 HCl V26016 MRT-68921 HCl 2080306-21-2 MRT-68921 HCl, the hydrochloride salt ofMRT68921, is a dual inhibitor of ULK1 and ULK2 (theautophagy kinases) with potential anticancer activity.
MRT68921 V26017 MRT68921 1190379-70-4 MRT-68921 (MRT68921; MRT 68921) is a novel, potent and dual inhibitor of theautophagy kinase ULK1 and ULK2 with IC50s of 2.9 and 1.1 nM, respectively.
MRT68921 hydrochloride V75974 MRT68921 hydrochloride 2070014-87-6 MRT68921 HCl is a potent inhibitor of ULK1 and ULK2 with IC50s of 2.9 nM and 1.1 nM respectively.
SBP-7455 V2248 SBP-7455 1884222-74-5 SBP-7455 is a potent, high-affinity, orally bioactive dual ULK1/ULK2 autophagy inhibitor (antagonist) with IC50 of 13 nM and 476 nM, respectively, in the ADP-Glo assay.
ULK-101 V75975 ULK-101 2443816-45-1 ULK-101 is a potent and specific ULK1 inhibitor (antagonist) with in vitro IC50s of 1.6 nM and 30 nM for ULK1 and ULK2, respectively.
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