Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.
Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0655 | Entospletinib (GS9973) | 1229208-44-9 | Entospletinib (formerly known as GS-9973) is a novel, potent, orally bioavailable, and highly selective Syk inhibitor with potential anti-inflammatory and immunomodulatory activities. |
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V0653 | Fostamatinib (R788; Tavalisse) | 901119-35-5 | Fostamatinib (formerly also known as R788; trade name:Tavalisse), a prodrug of the active metabolite R406, is an orally bioactive, potent and selective Syk inhibitor with potential anti-inflammatory activity. |
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V0657 | Fostamatinib Disodium (R788; Tavalisse) | 1025687-58-4 | Fostamatinib disodium (also known as R-788; R-935788; brand name:Tavalisse) is the prodrug form of the active metabolite R406. |
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V0654 | Piceatannol (Astringenin; NSC-622471; trans-Piceatannol) | 10083-24-6 | Piceatannol (also known as Astringenin; NSC-622471; trans-Piceatannol), a naturally occuring stilbene, is a potent and selective Syk inhibitor and shows ~10-fold selectivity for Srk over Lyn. |
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V2680 | PRT-060318 | 1194961-19-7 | PRT-060318 (also known as PRT318) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
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V0652 | PRT062607 (P505-15, BIIB057) HCl | 1370261-97-4 | PRT062607 (also known as P505-15, BIIB-057) HCl is a novel, potent, highly selective and orally bioavailablesmall molecule Syk inhibitor with potential anti-inflammatory activity. |
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V2390 | SRX3207 | 2254693-15-5 | SRX-3207 (SRX3207) is a novel, potent, orally bioactive and dual inhibitor of Syk-PI3K withanti-tumor activity. |
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V69783 | Syk Inhibitor II dihydrochloride | 227449-73-2 | Syk Inhibitor II di-HCl is a specific and ATP-competitive Syk inhibitor (antagonist) with IC50 of 41 nM. |
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V51506 | SYK/JAK-IN-1 | 2737326-28-0 | SYK/JAK-IN-1 is a dual SYK/JAK inhibitor (antagonist) with IC50 of <5 nM for SYK and JAK2 respectively. |
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V0651 | Tamatinib (R-406) | 841290-80-0 | Tamatinib (formerly known as R406) is a novel potent and ATP competitive Syk inhibitor with potential to treat immune disorders and inflammatory conditions. |
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