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Syk

Syk

Syk, or spleen tyrosine kinase, is a highly expressed cytosolic non-receptor protein tyrosine kinase (PTK) found in both hematopoietic and non-hematopoietic cells, including mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages.

Syk mediates important signal transduction pathways after immune cell receptors are activated. In addition to osteoclasts and breast cancer cells, Syk binds to various receptors on the surface of a wide range of cells, including B cells, mast cells, monocytes, macrophages, and neutrophils. SYK is activated after these receptors are activated by their ligands and orchestrates a variety of cellular responses, including the production of cytokines (in T cells and monocytes) and phagocytosis (in macrophages).

Syk related products

Structure Cat No. Product Name CAS No. Product Description
(rel)-PRT062607 V111571 (rel)-PRT062607 1194954-52-3 (rel)-PRT062607 ((rel)-P505-15) is the relative configuration of PRT062607.
As48 V129486 As48 1214405-38-5 As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assays.
Asebogenin V88080 Asebogenin 520-42-3 Asebogenin has anti-malarial activity in vitro.
BI 894416 V130129 BI 894416 1810059-82-5 BI 894416 is a spleen tyrosine kinase (SYK) inhibitor.
DBMB V133300 DBMB 314027-66-2 DBMB is a spleen tyrosine kinase (Syk) inhibitor that can significantly inhibit the activity of Syk kinase.
GT103 V136985 GT103 GT103 is a human monoclonal antibody that targets complement factor H (CFH).
Ibt-DOX V137762 Ibt-DOX Ibt-DOX is a BTK inhibitor with an IC50 value of 2.89 nM.
IQS-019 V115509 IQS-019 1630804-24-8 IQS-019 is a B cell receptor (BCR) kinase inhibitor.
MK-8457 V88079 MK-8457 1312518-84-5 MK-8457 is a dual SYK/ZAP70 inhibitor.
MTX-216 V140486 MTX-216 1952236-19-9 MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR.
NMS-0963 V88078 NMS-0963 2765304-82-1 NMS-0963 (compound 1) is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 3 nM.
PRT-060318 V2680 PRT-060318 1194961-19-7 PRT-060318 (also known as PRT318) is a novel, potent,selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
PRT-060318 dihydrochloride V112026 PRT-060318 dihydrochloride 3032567-93-1 PRT-060318 (PRT318) dihydrochloride is a potent, selective, and orally effective tyrosine kinase Syk inhibitor with an IC50 of 3 nM.
PRT062607 (P505-15, BIIB057) HCl V0652 PRT062607 (P505-15, BIIB057) HCl 1370261-97-4 PRT062607 (also known as P505-15, BIIB-057) HCl is a novel, potent, highly selective and orally bioavailablesmall molecule Syk inhibitor with potential anti-inflammatory activity.
SRX3207 V2390 SRX3207 2254693-15-5 SRX-3207 (SRX3207) is a novel, potent, orally bioactive and dual inhibitor of Syk-PI3K withanti-tumor activity.
Syk Inhibitor II dihydrochloride V69783 Syk Inhibitor II dihydrochloride 227449-73-2 Syk Inhibitor II di-HCl is a specific and ATP-competitive Syk inhibitor (antagonist) with IC50 of 41 nM.
Syk Inhibitor II hydrochloride V88081 Syk Inhibitor II hydrochloride 2490508-82-0 Syk Inhibitor II hydrochloride is a potent, highly selective and ATP-competitive Syk inhibitor with IC50 of 41 nM.
Syk-IN-13 V145484 Syk-IN-13 1360905-04-9 Syk-IN-13 is a Syk inhibitor that may be used in research on rheumatoid arthritis and/or systemic lupus erythematosus.
SYK/JAK-IN-1 V51506 SYK/JAK-IN-1 2737326-28-0 SYK/JAK-IN-1 is a dual SYK/JAK inhibitor (antagonist) with IC50 of <5 nM for SYK and JAK2 respectively.
T2M-010 V117100 T2M-010 364611-21-2 T2M-010 is a potent TREM2 agonist that can cross the blood-brain barrier (Kd = 0.83 μM).
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