Somatostatin Receptor

Somatostatin Receptor

Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family. Many human tumors, including the majority of neuroendocrine tumors, breast tumors, some brain tumors, renal cell tumors, lymphomas, and prostate cancer, express somatostatin receptors. By binding to somatostatin receptors, somatostatin produces cytotoxic and cytostatic effects as well as a general secretion-inhibiting effect.

While SSTR5 is selective for somatostatin-28, SSTRs 1-4 exhibit weak selectivity for somatostatin-14 binding. SSTRs 2, 3, and 5 belong to a similar somatostatin receptor subclass based on structural similarity and reactivity for octapeptide and hexapeptide somatostatin receptor analogs; SSTRs 1-4 react poorly with these analogs and belong to a different subclass. Through pertussis toxin-sensitive guanosine triphosphate (GTP)-binding proteins, the inhibition of adenylyl cyclase is functionally linked to all five somatostatin receptors. The mRNA for SSTRs 1–5 is widely expressed in the brain and other peripheral organs, and it shows an overlapping, distinctive pattern that is species- and tissue-specific as well as subtype-specific. SSTR2 and SSTR5 are expressed by all subsets of pituitary cells, with SSTR5 being more prevalent. Pituitary cells coexpress various subtypes of somatostatin receptors.

Somatostatin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 V70057 (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1 (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective, non-peptide human somatostatin receptor subtype 2 (sst2) agonist.
[Nle8] Somatostatin (1-28) V70058 [Nle8] Somatostatin (1-28) 84768-30-9 [Nle8] Somatostatin (1-28) is an analogue of somatostatin (1-28) with norleucine at position 8 replacing methionine.
Angiopeptin TFA (Angiopeptin trifluoroacetate) V70053 Angiopeptin TFA (Angiopeptin trifluoroacetate) 2478421-60-0 Angiopeptin TFA is a cyclic octapeptide analog of somatostatin and a partial agonist of sst2/sst5 receptors with IC50s of 0.26 nM and 6.92 nM respectively.
BIM-23056 V70052 BIM-23056 150155-61-6 BIM 23056 is a linear octapeptide that is a potent sst3 and sst5 somatostatin receptor antagonist (inhibitor) with Kis of 10.8 and 5.7, respectively.
BIM-23056 TFA V70061 BIM-23056 TFA 1426173-61-6 BIM 23056 TFA is a linear octapeptide and a potent sst3 and sst5 somatostatin receptor antagonist (inhibitor) with Kis of 10.8 and 5.7 respectively.
BIM-23190 V50993 BIM-23190 182153-96-4 BIM-23190 is an analog of somatostatin and a selective agonist of SSTR2 and SSTR5.
BIM-23190 hydrochloride V77206 BIM-23190 hydrochloride BIM-23190 HCl is an analog of somatostatin and a selective agonist of SSTR2 and SSTR5.
CH 275 V70054 CH 275 174688-78-9 CH 275 is a bioactive peptide analog of somatostatin that binds to somatostatin receptor 1 (sst1) (Ki=52 nM).
Cortistatin 29 V77140 Cortistatin 29 Cortistatin 29 is a neuropeptide.
Cortistatin-29 (human) V70062 Cortistatin-29 (human) 1815618-16-6 Cortistatin-29 (human) is a somatostatin neuropeptide with potential for studying diseases like cancer, inflammation, autoimmunity, fibrosis, and pain.
Cyclic SSTR agonist octreotide V78951 Cyclic SSTR agonist octreotide Cyclic SSTR agonist octreotide is an Octreotide that works as an agonist of the somatostatin receptor (SSTR).
Cyclosomatostatin V70048 Cyclosomatostatin 84211-54-1 Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist.
Cyclosomatostatin TFA V78957 Cyclosomatostatin TFA Cyclosomatostatin TFA is a potent somatostatin (SST) receptor antagonist.
CYN 154806 TFA V70047 CYN 154806 TFA 2828432-46-6 CYN 154806 TFA is a cyclic octapeptide and a potent and specific antagonist of somatostatin sst2 receptor.
DOTA-JR11 V70055 DOTA-JR11 1039726-31-2 DOTA-JR11 is an antagonist of the somatostatin receptor SSTR2.
DOTA-LM3 V70049 DOTA-LM3 1192362-32-5 DOTA-LM3 is a somatostatin receptor (SSTR) antagonist.
DOTA-LM3 TFA V77072 DOTA-LM3 TFA DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist.
J-2156 TFA V70050 J-2156 TFA 2387505-73-7 J-2156 TFA is a potent and specific somatostatin receptor type 4 (SST4) agonist/activator with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively.
L-779976 V50904 L-779976 214770-19-1 somatostatin receptor agonist
L-803087 TFA V70056 L-803087 TFA 1786412-46-1 L-803087 TFA is a potent and specific somatostatin sst4 receptor agonist/activator with a Ki of 0.7 nM and is more than 280 times more selective for sst4 than other somatostatin receptors.
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