The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.
Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0441 | (Z)-SMI-4a | 438190-29-5 | Z)-SMI-4a (the Z-enantiomer of SMI-4a), a novel benzylidene-thiazolidine-2, 4-dione small molecule, is a potent and selectivePim1inhibitorwith potential antineoplastic activity. |
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V0442 | AZD1208 | 1204144-28-4 | AZD1208 is a novel, highly selective,ATP-competitiveand orally bioavailable small molecule pan-inhibitor of Pim kinase with potential antitumor activity. |
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V112337 | CSH-4044 | CSH-4044 can be isolated from fermented wheat germ extract. | |
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V2552 | CX-6258 | 1202916-90-2 | CX-6258 is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
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V0443 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity. |
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V114915 | GDC-0570 | 1586041-58-8 | GDC-0570 is a novel, highly effective, selective, and orally available pan-PIM inhibitor. |
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V114340 | JP-11646 | 1902983-63-4 | JP-11646 is a pan-PIM inhibitor with significantly enhanced inhibitory efficacy against PIM2 (IC50 = 0.5 nM). |
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V116237 | NMS-P645 | 1482518-95-5 | NMS-P645 is a PIM1 inhibitor. |
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V96680 | Pim-1 kinase inhibitor 11 | Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with IC50 of 0.18 μM. | |
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V84773 | Pim-1 kinase inhibitor 9 | ||
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V117606 | Pim-1 kinase-IN-14 | The IC50 value of the Pim-1 kinase inhibitor IN-14 is 94 nM. | |
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V116707 | Pim-1 kinase-IN-15 | Pim-1 kinase-IN-15 (compound 15) is a highly potent and selective Pim-1 kinase inhibitor (IC50 = 0.212 μM). | |
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V85774 | Pim-1/2 kinase inhibitor 2 | 2918764-16-4 | |
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V87039 | PIM3-IN-1 hydrochloride | PIM3-IN-1 hydrochloride (Compound 19a) is a (PIM2/3) inhibitor, with the highest inhibition against PIM3, with IC50 values in the nanomolar range. | |
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V2728 | PIM447 | 1210608-43-7 | PIM447 (also known as LGH447)is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. |
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V0440 | SGI-1776 | 1025065-69-3 | SGI-1776 is a novel, potent and ATP-competitive pan-inhibitor of the serine/threonine family of Pim kinase (an enzyme regulating cell survival) with potential antitumor activity. |
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V3019 | TP-3654 | 1361951-15-6 | TP-3654 is a novel and potent inhibitor of Pim-1 and Pim-3 (proviral integration site for moloney murine leukemia virus) kinase that is potentially useful for the treatment of various cancers such as prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis. |
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