The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.
Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0441 | (Z)-SMI-4a | 438190-29-5 | Z)-SMI-4a (the Z-enantiomer of SMI-4a), a novel benzylidene-thiazolidine-2, 4-dione small molecule, is a potent and selectivePim1inhibitorwith potential antineoplastic activity. |
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V0442 | AZD1208 | 1204144-28-4 | AZD1208 is a novel, highly selective,ATP-competitiveand orally bioavailable small molecule pan-inhibitor of Pim kinase with potential antitumor activity. |
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V2552 | CX-6258 | 1202916-90-2 | CX-6258 is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
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V0443 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity. |
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V2728 | PIM447 | 1210608-43-7 | PIM447 (also known as LGH447)is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. |
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V0440 | SGI-1776 | 1025065-69-3 | SGI-1776 is a novel, potent and ATP-competitive pan-inhibitor of the serine/threonine family of Pim kinase (an enzyme regulating cell survival) with potential antitumor activity. |
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V3019 | TP-3654 | 1361951-15-6 | TP-3654 is a novel and potent inhibitor of Pim-1 and Pim-3 (proviral integration site for moloney murine leukemia virus) kinase that is potentially useful for the treatment of various cancers such as prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis. |
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