Pim

Pim

The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.

Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.

Pim related products

Structure Cat No. Product Name CAS No. Product Description
V0441 (Z)-SMI-4a 438190-29-5 Z)-SMI-4a (the Z-enantiomer of SMI-4a), a novel benzylidene-thiazolidine-2, 4-dione small molecule, is a potent and selectivePim1inhibitorwith potential antineoplastic activity.
V0442 AZD1208 1204144-28-4 AZD1208 is a novel, highly selective,ATP-competitiveand orally bioavailable small molecule pan-inhibitor of Pim kinase with potential antitumor activity.
V2552 CX-6258 1202916-90-2 CX-6258 is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.
V0443 CX-6258 HCl 1353859-00-3 CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity.
V84773 Pim-1 kinase inhibitor 9
V85774 Pim-1/2 kinase inhibitor 2 2918764-16-4
V2728 PIM447 1210608-43-7 PIM447 (also known as LGH447)is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively.
V0440 SGI-1776 1025065-69-3 SGI-1776 is a novel, potent and ATP-competitive pan-inhibitor of the serine/threonine family of Pim kinase (an enzyme regulating cell survival) with potential antitumor activity.
V3019 TP-3654 1361951-15-6 TP-3654 is a novel and potent inhibitor of Pim-1 and Pim-3 (proviral integration site for moloney murine leukemia virus) kinase that is potentially useful for the treatment of various cancers such as prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis.
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