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Pim

Pim

The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.

Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.

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