Poly (ADP-ribose) glycohydrolase (PARG) is the primary hydrolase involved in the degradation of poly(ADP-ribose) (PAR).Both endo- and exo-glycohydrolase activity are present in PARG, with the latter activity being preferentially carried out by binding to the two ADP-ribose residues that are furthest from the PAR chain. Free PAR and mono ADP-ribose moieties are produced by these various catalytic methods, respectively. By ADP-ribose pyrophosphohydrolases like the NUDIX family, the free mono ADP-ribose is then converted into AMP and ribose 5′ phosphate. While ribose 5′ phosphate is a precursor to many biomolecules including DNA, RNA, and ATP, AMP is used in the ATP reformation process as well as various metabolic and cell signaling pathways. The production of free PAR chains as a result of hyper-PARP activation is thought to be the main cause of endo-glycohydrolase activity, which is then associated with apoptosis and thought to function as a death signal.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V41929 | COH-34 | 906439-72-3 | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor (antagonist) with IC50 of 0.37 nM. |
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V53354 | COH34 analog 1 | 314248-24-3 | COH34 analog 1, a metabolite, is an oxidation analog of COH34. |
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V75783 | Endo-1,4-β-xylanase (Xylanase; CtXyn11A; EC 3.2.1.8) | 9025-57-4 | Endo-1,4-β-xylanase (Xylanase) is an Arabinoxylan (AX) arabinoxylan-degrading enzyme and glycoside hydrolase widely used in biochemical research. |
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V51927 | JA2131 | 6505-99-3 | JA2131 is a small molecule inhibitor with an IC50 of 0.4 μM that specifically targets polyADP-ribose hydrolase (PARG). |
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V75782 | PARG-IN-4 | 2988890-20-4 | PARG-IN-4 (Formula (A)) is an orally bioactive and cell-permeable (penetrable) PARG inhibitor. |
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V94052 | PARP-1-IN-32 | 374069-33-7 | PARP-1-IN-32 (Compound 15) is a poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor. |
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V50971 | PDD-00017272 | 1945950-20-8 | PDD00017272 is a novel PARG (Poly(ADP-ribose) Glycohydrolase) inhibitor, showing an EC50 of 9.2 nM in cell POM and 4.8 nM in biochemical assay, respectively. |
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V53043 | PDD00017238 | 1952247-05-0 | PDD00017238 is a potent inhibitor of poly(adenosine diphosphate ribose) hydrolase (PARG) with EC50s of 40 nM and 55 nM. |
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V51289 | pNP-ADPr | 939028-75-8 | pNP-ADPr is a colorimetric substrate used in the first continuous assays for the activity of ADP-ribosyl hydrolase 3 (ARH3) and Poly(ADP-ribose) glycohydrolase (PARG). |
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