Metoprolol Tartrate

Alias: CGP 2175E; Lanoc; Lopressor; CGP2175E; CGP-2175E; Metomerck; Metop; Selopral; Ritmolol; Metoprolol Tartrate

Cat No.:V1153 Purity: ≥98%

COA Product Data Instructions for use SDS

Metoprolol Tartrate (CGP2175E; CGP-2175E; Lanoc; Lopressor; Metomerck; Metop; Selopral; Ritmolol), the tartrate salt of Metoprolol, is a potent and cardioselective β1 receptor blocker with antihypertensive effects.

Metoprolol Tartrate Chemical Structure CAS No.: 56392-17-7
Product category: Adrenergic Receptor

This product is for research use only, not for human use. We do not sell to patients.

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Top Publications Citing lnvivochem Products

Nature 2021, 597(7874):119-125.

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Science Trans Med 2023, 15: eadd7872.

Cancer Cell 2021,39(4):529-547.e7.

Cancer Discov 2022,12(4):1106-1127.

Immunity 2023,56(3):620-634.e11.

J Am Chem Soc 2022,144:21831-21836.

Cell 2020,183:1202-1218.e25.

Science Adv 2022:8,eabm9427.

Nature 2021,597(7874):119-125.

Cell 2020,183:1202-1218.e25.

PNAS Nexus 2022,1(3):pgac063.

ACS Nano 2023,17(10):9110-9125.

Biomaterial 2023 Sep16:302:122333.

Purity & Quality Control Documentation

Current batch：

Purity: ≥98%

COA

MSDS

NMR

Instructions

Product Description
Bioactivity & Protocols
Physicochemical Properties
Solubility Data
Calculators
Clinical Trial Information
Biological Data

Product Description

Biological Activity I Assay Protocols (From Reference)

Targets	β-adrenergic receptor
ln Vitro	Metoprolol (0-1000 μg/mL; 24-72 h) exhibits dose- and time-dependent cytotoxicity on MOLT-4 and U937 cells[3].
ln Vivo	Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) decreases atherosclerosis and proinflammatory cytokines in ApoE^-/- mice[1]. Metoprolol (15 mg/kg/q12h; i.e., 5 days) exhibits anti-viral and anti-inflammatory properties in a murine model of viral myocarditis caused by the coxsackievirus B3[2]. Metoprolol (2.5 mg/kg; intravenously; three bolus injections) inhibits myocardial apoptosis and significantly reduces the expression of activated caspase-9 protein in coronary microembolization (CME) rats[4].
Cell Assay	Cell Line: U937 and MOLT-4 cells Concentration: 1, 10, 50, 100, 500 and 1000 μg/mL Incubation Time: 24, 48 and 72 h Result: Significantly reduced the viability of MOLT-4 and U937 cells at 1000 μg/mL (3740.14µM) concentration after 48 hours of incubation; similarly, after 72 hours, the viability of MOLT4 cells at ≥100 μg/ml (≥374.01µM) concentrations and U937 cells at ≥500 μg/ml (≥1870.07µM) concentrations was observed.
Animal Protocol	Male ApoE^-/- mice 2.5 mg/kg/h Via osmotic minipumps, 11 weeks
References	[1]. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783. [2]. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547(2):195-201. [3]. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10(4): 124-129. [4]. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18(2):161-5.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula

C34H56N2O12

Molecular Weight

684.81

Exact Mass

684.38

Elemental Analysis

C, 59.63; H, 8.24; N, 4.09; O, 28.03

CAS #

56392-17-7

Related CAS #

Metoprolol; 51384-51-1; Metoprolol succinate; 98418-47-4; Metoprolol-d7 hydrochloride; 1219798-61-4; Metoprolol-d6 tartrate

Appearance

White to off-white crystalline powder

SMILES

CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O

InChi Key

YGULWPYYGQCFMP-UHFFFAOYSA-N

InChi Code

InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)

Chemical Name

2,3-dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Synonyms

CGP 2175E; Lanoc; Lopressor; CGP2175E; CGP-2175E; Metomerck; Metop; Selopral; Ritmolol; Metoprolol Tartrate

HS Tariff Code

2934.99.9001

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)

DMSO: ~100 mg/mL (~146.0 mM)

Water: ~100 mg/mL (~146.0 mM)

Ethanol: ~31 mg/mL (~45.2 mM)

Solubility (In Vivo)

Chemical Name:(R)-1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol hemi((2R)-2,3-dihydroxysuccinate)

InChi Key:YGULWPYYGQCFMP-RBXXDJRDSA-N

InChi Code:InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*14-;1-,2?/m111/s1

SMILES Code:O[C@H](CNC(C)C)COC1=CC=C(CCOC)C=C1.O[C@H](CNC(C)C)COC2=CC=C(CCOC)C=C2.O=C(O)[C@H](O)C(O)C(O)=O

(Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4603 mL	7.3013 mL	14.6026 mL
	5 mM	0.2921 mL	1.4603 mL	2.9205 mL
	10 mM	0.1460 mL	0.7301 mL	1.4603 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Mass

Concentration

Volume

Molecular Weight*

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Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

Calculate the Mass of a compound required to prepare a solution of known volume and concentration
Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?

Enter 350.26 in the Molecular Weight (MW) box
Enter 10 in the Concentration box and choose the correct unit (mM)
Enter 5 in the Volume box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:

Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
Enter 25 into the Concentration (End) box and select the correct unit (mM)
Enter 25 into the Volume (End) box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box

Molecular formula

Total molecular weight

g/mol

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Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
Click the “Calculate” button
The answer appears in the Volume (to add to vial) box

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)

Dosage mg/kg

Average weight of animals g

Dosing volume per animal μL

Number of animals

Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)

% DMSO

% Tween 80

% ddH₂O

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Calculation results

Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O，mix and clarify.

Note： (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Clinical Trial Information

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02123056	Active Recruiting	Drug: Metoprolol Drug: Matching Placebo	Vasovagal Syncope	University of Calgary	October 2014	Phase 4
NCT01608893	Active Recruiting	Drug: Carvedilol Drug: Metoprolol	Atrial Fibrillation	University of Calgary	May 2012	Not Applicable
NCT03278509	Active Recruiting	Drug: Metoprolol Succinate Drug: Bisoprolol	Acute Myocardial InfarctionST Elevation Myocardial Infarction	Karolinska Institutet	September 11, 2017	Phase 4
NCT03070184	Active Recruiting	Other: Exercise challenge Drug: Metoprolol Succinate ER	Healthy Pre Hypertension	University of Alabama at Birmingham	April 30, 2017	Phase 2
NCT05741385	Recruiting	Drug: Caffeine Drug: Warfarin sodium Drug: Omeprazole Drug: Metoprolol	Liver Cirrhosis	Boehringer Ingelheim	April 25, 2023	Not Applicable

Biological Data

Metoprolol dose-finding (Study I). (a) 24-hour heart rate during baseline conditions after three different doses of metoprolol compared with Control mice. Biomed Res Int . 2014:2014:548783
Metoprolol decreases atherosclerosis. Biomed Res Int . 2014:2014:548783.
Photomicrographs showing the effect of metoprolol on apoptosis following coronary microembolization (original magnification ×400). Exp Clin Cardiol . 2013 Spring;18(2):161-5.
Graph showing the effect of metoprolol on apoptosis following coronary microembolization (CME). Exp Clin Cardiol . 2013 Spring;18(2):161-5.