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DNA(RNA) Synthesis

DNA(RNA) Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.

In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.

M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.

DNA(RNA) Synthesis related products

Structure Cat No. Product Name CAS No. Product Description
(+)-TK216 V52845 (+)-TK216 1903783-77-6 (+)-TK216 is the enantiomer of TK216.
(-)-TK216 V52847 (-)-TK216 1903783-78-7 (-)-TK216 is the enantiomer of TK216 (HY-122903).
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl isopropyl diisopropylphosphoramidite V121437 (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl isopropyl diisopropylphosphoramidite (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl isopropyl diisopropylphosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(E)-(Dimethylamino)methylene-2'-F-dG-CE phosphoramidite V121713 (E)-(Dimethylamino)methylene-2'-F-dG-CE phosphoramidite 3081868-42-7 (E)-(Dimethylamino)methylene-2'-F-dG-CE phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(E)-Antiviral agent 67 V121760 (E)-Antiviral agent 67 132603-49-7 (E)-Antiviral agent 67 is a pyrazolone antiviral agent that has some inhibitory activity against RNA-dependent RNA polymerase.
(E)-Azobenzene phosphoramidite V121762 (E)-Azobenzene phosphoramidite 365530-91-2 (E)-Azobenzene phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(E/Z)-3-Cyanovinylcarbazole phosphoramidite V121793 (E/Z)-3-Cyanovinylcarbazole phosphoramidite 1044273-24-6 (E/Z)-3-Cyanovinylcarbazole phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(E/Z)-NSAH V55140 (E/Z)-NSAH 54009-54-0 (E/Z)-NSAH is an isomer of NSAH (HY-114503).
(R)-Beta-D-homoDNA-C(Bz)-phosphoramidite V121903 (R)-Beta-D-homoDNA-C(Bz)-phosphoramidite 145594-07-6 (R)-Beta-D-homoDNA-C(Bz)-phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(R)-GNA-U phosphoramidite V121929 (R)-GNA-U phosphoramidite 2940934-04-1 (R)-GNA-U phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(S)-Beta-D-homoDNA-C(Bz)-phosphoramidite V122149 (S)-Beta-D-homoDNA-C(Bz)-phosphoramidite 145610-77-1 (S)-Beta-D-homoDNA-C(Bz)-phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
(S,S)-D211 V113157 (S,S)-D211 1971075-99-6 (S,S)-D211 is a stereoisomer of D211.
(±)2-(14,15-Epoxyeicosatrienoyl) glycerol V104053 (±)2-(14,15-Epoxyeicosatrienoyl) glycerol 848667-56-1 (±)2-(14,15-Epoxyeicosatrienoyl)glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-arachidonoylglycerol (2-AG) in the kidney.
1,4-Anthraquinone V52527 1,4-Anthraquinone 635-12-1 1,4-Anthraquinone is a novel anticancer agent.
1,7-Heptanediamine V96929 1,7-Heptanediamine 646-19-5 1,7-Heptanediamine (C7) is a deoxyalkali synthase inhibitor with IC50 of 4.5 μM.
1-Hydroxyanthraquinone (1-羟基蒽醌) V53307 1-Hydroxyanthraquinone 129-43-1 1-Hydroxyanthraquinone is an orally bioactive naturally occurring compound developed from some plants like Tabebuia avellanedae and has carcinogenic effects.
1-Me-dA-CE Phosphoramidite V123600 1-Me-dA-CE Phosphoramidite 945026-45-9 1-Me-dA-CE Phosphoramidite is a phosphoramidite that can be used for oligonucleotide synthesis.
1-p-Chlorobenzyl-1,2,3-triazole-5′-O-DMT-dU Phosphoramidite V77531 1-p-Chlorobenzyl-1,2,3-triazole-5′-O-DMT-dU Phosphoramidite 1-p-Chlorobenzyl-1,2,3-triazole-5′-O-DMT-dU Phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides.
12(S)-HETE V84362 12(S)-HETE 54397-83-0
16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) V83605 16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) 41692-24-4
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