Phospholipase is one of a very complex group of enzymes that converts phospholipids into fatty acids and other compounds. The enzymatic reaction that phospholipases catalyze serves to define them. Phospholipase A, which has members A1 and A2, Phospholipase B, which can perform both A1 and A2 reactions, Phospholipase C, and Phospholipase D are the classes.
Fatty acids and lysophospholipids are produced when phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids. Phospholipase C (PLC) transforms inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (PIP2). DAG and IP3 each regulate a variety of cellular processes and serve as a starting point for the creation of additional significant signaling molecules. PLC serves as the hub of numerous significant interconnected regulatory networks. The production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes like membrane trafficking, actin cytoskeleton remodeling, cell proliferation, and cell survival, is carried out by the crucial enzyme phospholipase D (PLD).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73547 | (R)-Bromoenol lactone ((R,E)-Bromoenol lactone) | 478288-90-3 | (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase gamma (iPLA2γ). |
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V83539 | (R)-N-(1-Hydroxypropan-2-yl)palmitamide | 142128-47-0 | |
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V73552 | (S)-Bromoenol lactone ((S)-BEL; (S,E)-Bromoenol lactone) | 478288-94-7 | (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) in rat aortic smooth muscle (A10) cells Vasopressin-induced release of arachidonic acid with IC50 of 2 µM. |
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V73548 | (Z)-Oleyloxyethyl phosphorylcholine | 84601-19-4 | (Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). |
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V122639 | 1,2-Bis(heptanoylthio)-sn-glycero-3-PG sodium | 1,2-Bis(heptanoylthio)-sn-glycero-3-PG sodium is a fatty acylthioesterified phosphatidylglycerol derivative that can be used to mimic the action of phospholipases or as a probe molecule for membrane fusion studies. | |
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V104340 | 1-Myristoyl-2-Linoleoyl-sn-glycero-3-PC | 92345-33-0 | 1-Myristoyl-2-linoleoyl-sn-glycero-3-PC is a phospholipid that contains myristic acid and linoleic acid at the sn-1 and sn-2 positions, respectively, in human plasma. |
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V126910 | 5-Bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate ammonium | 212515-11-2 | 5-Bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate ammonium is a chromogenic substrate that can be used to detect the activity of phosphatidylinositol-specific phospholipase C (PI-PLC). |
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V87677 | 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid | 89560-01-0 | 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) is a phospholipase inhibitor and a non-metabolized analog of arachidonic acid or eicosadienoic acid. |
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V80027 | A3373 | 2324948-66-3 | A3373 is a new chemical phospholipase (Phospholipase) D1 (PLD1) and PLD2 inhibitor (antagonist) with IC50s of 325 nM and 15.15? Plays an important role in osteoclastogenesis. |
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V78499 | A4333 | 3025827-56-6 | A4333 is a biotinylated compound of A3373 that can inhibit phospholipase D1 (PLD1) but not PLD2. |
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V103972 | ABC47 | 1831135-57-9 | ABC47 is a potent serine hydrolase inhibitor. |
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V3849 | ACA | 110683-10-8 | ACA [also known as N-(p-amylcinnamoyl) Anthranilic Acid] is a broad-spectrum inhibitor ofphospholipase A2 (PLA2) and a TRP channel blocker. |
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V129364 | ARC39 | 15049-89-5 | ARC39 is an acid sphingomyelinase (ASM) inhibitor. |
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V99628 | ARF1 (2-17) | 143228-35-7 | ARF1 (2-17) inhibits both ARF-independent (ie, PLC-β) and ARF-dependent (ie, PLD) pathways. |
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V73540 | ASM-IN-1 | 2913151-46-7 | ASM-IN-1 is a potent orally bioactive acid sphingomyelinase (ASM) inhibitor (antagonist) with IC50 of 1.5 µM. |
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V87679 | ASM-IN-2 | 2305789-66-4 | ASM-IN-2 (compound 46) is a potent and potent inhibitor of ASM with an IC50 value of 0.87 μM and exhibits good drug-like properties. |
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V105301 | ASM-IN-3 | 2342576-75-2 | ASM-IN-3 (compound 21b) is a selective, blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor (IC50 of purified human ASM is 3.37 μM). |
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V5285 | BAPTA | 85233-19-8 | BAPTA is a selective calcium chelator. |
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V6123 | BAPTA Tetrasodium | 126824-24-6 | BAPTA tetrasodium is a selective calcium chelator. |
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V115797 | BMS-188184 | 161914-56-3 | BMS-188184 is a type II s-PLA2 inhibitor (IC50 = 17 µM). |
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