Phospholipase

Phospholipase

Phospholipase is one of a very complex group of enzymes that converts phospholipids into fatty acids and other compounds. The enzymatic reaction that phospholipases catalyze serves to define them. Phospholipase A, which has members A1 and A2, Phospholipase B, which can perform both A1 and A2 reactions, Phospholipase C, and Phospholipase D are the classes.
Fatty acids and lysophospholipids are produced when phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids. Phospholipase C (PLC) transforms inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (PIP2). DAG and IP3 each regulate a variety of cellular processes and serve as a starting point for the creation of additional significant signaling molecules. PLC serves as the hub of numerous significant interconnected regulatory networks. The production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes like membrane trafficking, actin cytoskeleton remodeling, cell proliferation, and cell survival, is carried out by the crucial enzyme phospholipase D (PLD).

Phospholipase related products

Structure Cat No. Product Name CAS No. Product Description
V73547 (R)-Bromoenol lactone ((R,E)-Bromoenol lactone) 478288-90-3 (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase gamma (iPLA2γ).
V83539 (R)-N-(1-Hydroxypropan-2-yl)palmitamide 142128-47-0
V73552 (S)-Bromoenol lactone ((S)-BEL; (S,E)-Bromoenol lactone) 478288-94-7 (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) in rat aortic smooth muscle (A10) cells Vasopressin-induced release of arachidonic acid with IC50 of 2 µM.
V73548 (Z)-Oleyloxyethyl phosphorylcholine 84601-19-4 (Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC).
V80027 A3373 A3373 is a new chemical phospholipase (Phospholipase) D1 (PLD1) and PLD2 inhibitor (antagonist) with IC50s of 325 nM and 15.15? Plays an important role in osteoclastogenesis.
V78499 A4333 A4333 is a biotinylated compound of A3373 that can inhibit phospholipase D1 (PLD1) but not PLD2.
V3849 ACA 110683-10-8 ACA [also known as N-(p-amylcinnamoyl) Anthranilic Acid] is a broad-spectrum inhibitor ofphospholipase A2 (PLA2) and a TRP channel blocker.
V73540 ASM-IN-1 2913151-46-7 ASM-IN-1 is a potent orally bioactive acid sphingomyelinase (ASM) inhibitor (antagonist) with IC50 of 1.5 µM.
V5285 BAPTA 85233-19-8 BAPTA is a selective calcium chelator.
V6123 BAPTA Tetrasodium 126824-24-6 BAPTA tetrasodium is a selective calcium chelator.
V73550 CAY10502 888320-29-4 CAY10502 is a potent calcium-dependent cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (antagonist) with IC50 of 4.3 nM against the isolated enzyme.
V2160 CAY10594 1130067-34-3 CAY10594 is a potent phospholipase D2 (PLD2) inhibitor (in vitro IC50=140 nM, cellular IC50=110 nM).
V2928 CAY10650 1233706-88-1 CAY10650 (CAY-10650) is a novel and highly potent inhibitor of cytosolic phospholipase A2α (cPLA2α) (IC50 = 12 nM) with anti-inflammatory activity.
V19410 Difluprednate 23674-86-4 Difluprednate (Durezol) is a corticosteroid thought to inhibit phospholipase A2 by inducing lipocortin.
V73538 DPTIP-prodrug 18 (P18) 2881068-33-1 DPTIP-prodrug 18 (P18) is an orally bioavailable, BBB (blood-brain barrier) permeable (penetrable) DPTIP precursor active molecule.
V5047 EA4 389614-94-2 EA4, a quinone derivative, is a novel and potent a rPLA2 inhibitor that inhibits rPLA2 with a Kiof 130 µM.
V73544 Folipastatin 139959-71-0 Folipastatin is a potent phospholipase A2 inhibitor (antagonist) with IC50 of 39 μM.
V73529 GSK2647544 1380426-95-8 GSK2647544 is an oral, selective Lp-PLA2 inhibitor.
V21862 GSK2814338 1420367-28-7 GSK2814338 (GSK-2814338) is a novel and potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) with the potential to be used for atherosclerosis and Alzheimer's disease.
V2778 GW4869 HCl 6823-69-4 GW4869 HCl (GW-4869; GW-69A;GW-554869A), the dihydrochloride salt ofGW4869, is a neutral, cell permeable and noncompetitive inhibitor of sphingomyelinase (SMase) (IC50 = 1 μM) and is most widely used pharmacological agent for blocking exosome generation.
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