Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells experience high temperatures or other types of stress, HSP expression rises. Transcriptional regulation controls this increase in expression. One of the most important aspects of the heat shock response is the dramatic upregulation of the heat shock proteins, which is primarily brought on by the heat shock factor (HSF). From bacteria to people, HSPs are present in almost all living things. Heat shock proteins seem to have an important cardiovascular function. There have been reports of the roles of alpha B crystallin, Hsp90, Hsp84, Hsp70, Hsp27, and Hsp20 in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67564 | 10,11-Dehydrocurvularin | 21178-57-4 | 10,11-Dehydrocurvularin is a common mycotoxin and antibiotic. |
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V2829 | Apoptozole | 1054543-47-3 | Apoptozole (formerly known asApoptosis Activator VII) is a potent and selective inhibitor of heat shock protein 70(HSP70) and Hsc70. |
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V73174 | BX-2819 | 1184181-50-7 | BX-2819 is an Hsp90 inhibitor (antagonist) with IC50 of 41 nM. |
|
V17743 | CCT251236 | 1693731-40-6 | CCT-251236, a chemical probe bisamide, is a novel, potent and orally bioavailable Pirin Ligand identified from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen (IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction). |
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V2678 | Chetomin | 1403-36-7 | Chetomin (also called NSC289491, BRN0077366), an antibiotic metabolite of chaetomium cochliodes and a natural product isolated from Chaetomium species which has anticancer, antibacterial and antifungal properties, is an inhibitor of HIF-1which weakens transcription of HIF-1, and disrupts the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. |
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V3430 | Debio 0932 (CUDC-305) | 1061318-81-7 | Debio 0932 (also known as CUDC-305) is a novel, potent and orally bioactive HSP90 (heat shock protein 90) inhibitor with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively. |
|
V73178 | Falcarinol (Panaxynol; Carotatoxin) | 21852-80-2 | Falcarinol (Panaxynol) is a natural, orally bioactive Hsp90 inhibitor that targets the N- and C-termini of Hsp90 and has limited toxicity. |
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V73181 | Flavokawain 1i (DiNap) | 1098176-51-2 | Flavokawain 1i (DiNap) is an Hsp90 inhibitor. |
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V2941 | HSF1A | 1196723-93-9 | HSF1A is acell-permeable andsmall-molecule activator of heat shock transcription factor 1 (HSF1). |
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V33368 | HSP70-IN-1( LUN-00465) | 1268273-90-0 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor; the IC50 for inhibiting the growth of Kasumi-1 cells is 2.3 μM. |
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V73180 | HSP70/SIRT2-IN-2 | 1796557-72-6 | HSP70/SIRT2-IN-2 (Compounds 1a) is a dual (bifunctional) inhibitor of SIRT2 and HSP70 with IC50 of 45.1±5.0 μM. |
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V73183 | HSP90-IN-10 | 2881071-86-7 | HSP90-IN-10 (Compound 16s) is a potent HSP90 inhibitor. |
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V73179 | HSP90-IN-27 | 525577-38-2 | HSP90-IN-27 (compound 19) is an HSP90 inhibitor. |
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V73176 | HSP90-IN-9 | 2765247-36-5 | HSP90-IN-9 is a potent and specific HSP90 inhibitor. |
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V32801 | JG-98 | 1456551-16-8 | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. |
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V22675 | MKT-077 | 147366-41-4 | MKT-077 (FJ-776) is a highly water-soluble (H2O-soluble) mitochondrial dye with significant anti-tumor activity. |
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V0090 | ML346 (CID-767276) | 100872-83-1 | ML346 (CID767276) is a novel and potent activator of heat shock protein 70 (Hsp70) (EC50 = 4600 nM in HeLa cell toxicity assay). |
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V2101 | Paeoniflorin (Peoniflorin) | 23180-57-6 | Paeoniflorin (Peoniflorin), a glycoside, is a herbal constituent extracted from the root of Paeonia albiflora Pall. |
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V27078 | Palmitic acid | 57-10-3 | Palmitic acid (PA) is a long-chain (16-carbon chain) saturated fatty acid commonly found in both animals and plants. |
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