HSP

HSP

Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells experience high temperatures or other types of stress, HSP expression rises. Transcriptional regulation controls this increase in expression. One of the most important aspects of the heat shock response is the dramatic upregulation of the heat shock proteins, which is primarily brought on by the heat shock factor (HSF). From bacteria to people, HSPs are present in almost all living things. Heat shock proteins seem to have an important cardiovascular function. There have been reports of the roles of alpha B crystallin, Hsp90, Hsp84, Hsp70, Hsp27, and Hsp20 in the cardiovasculature.

HSP related products

Structure Cat No. Product Name CAS No. Product Description
V67564 10,11-Dehydrocurvularin 21178-57-4
V2829 Apoptozole 1054543-47-3 Apoptozole (formerly known asApoptosis Activator VII) is a potent and selective inhibitor of heat shock protein 70(HSP70) and Hsc70.
V73174 BX-2819 1184181-50-7
V17743 CCT251236 1693731-40-6 CCT-251236, a chemical probe bisamide, is a novel, potent and orally bioavailable Pirin Ligand identified from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen (IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction).
V2678 Chetomin 1403-36-7 Chetomin (also called NSC289491, BRN0077366), an antibiotic metabolite of chaetomium cochliodes and a natural product isolated from Chaetomium species which has anticancer, antibacterial and antifungal properties, is an inhibitor of HIF-1which weakens transcription of HIF-1, and disrupts the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
V3430 Debio 0932 (CUDC-305) 1061318-81-7 Debio 0932 (also known as CUDC-305) is a novel, potent and orally bioactive HSP90 (heat shock protein 90) inhibitor with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
V73178 Falcarinol (Panaxynol; Carotatoxin) 21852-80-2
V73181 Flavokawain 1i (DiNap) 1098176-51-2
V2941 HSF1A 1196723-93-9 HSF1A is acell-permeable andsmall-molecule activator of heat shock transcription factor 1 (HSF1).
V33368 HSP70-IN-1( LUN-00465) 1268273-90-0 HSP70-IN-1 is a novel and potent heat shock protein (HSP) inhibitor.
V73180 HSP70/SIRT2-IN-2 1796557-72-6
V73183 HSP90-IN-10 2881071-86-7
V73179 HSP90-IN-27 525577-38-2
V73176 HSP90-IN-9 2765247-36-5
V32801 JG-98 1456551-16-8 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
V22675 MKT-077 147366-41-4 MKT-077 is an inhibitor of mitochondrial hsp70 family member mortalin (mot-2), causing the selective death of cancer cells.
V0090 ML346 (CID-767276) 100872-83-1 ML346 (CID767276) is a novel and potent activator of heat shock protein 70 (Hsp70) (EC50 = 4600 nM in HeLa cell toxicity assay).
V2101 Paeoniflorin (Peoniflorin) 23180-57-6 Paeoniflorin (Peoniflorin), a glycoside, is a herbal constituent extracted from the root of Paeonia albiflora Pall.
V27078 Palmitic acid 57-10-3 Palmitic acid (PA) is a long-chain (16-carbon chain) saturated fatty acid commonly found in both animals and plants.
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