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Glucosidase

Glucosidase

Glycoside hydrolase enzymes are glucosidases. A glucosidase that works on α(1→4) bonds is called α-glucosidase, and it is found in the small intestine's brush border. α-Glucosidase inhibitors are a new class of diabetes medications. It can effectively control blood sugar levels and prevent diabetic complications by lowering the postprandial blood sugar concentration.

In β-D-glucosides and oligosaccharides, β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues, releasing glucose in the process. Because of its crucial function in the breakdown of cellulose, the transformation of glycosides, and numerous other industrial processes, β-glucosidase has garnered a great deal of interest from the scientific community. In order to degrade cellulose, β-glucosidases are crucial because they catalyze the last stage of cellulose hydrolysis.

Glucosidase related products

Structure Cat No. Product Name CAS No. Product Description
(E)-p-Coumaramide V84809 (E)-p-Coumaramide 194940-15-3
(S)-N-(1H-Indole-3-acetyl)tryptophan V87473 (S)-N-(1H-Indole-3-acetyl)tryptophan 57105-53-0 (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a tryptophan derivative that weakly inhibits β-D-glucosidase.
1'-O-Methyl neochebulinate V85669 1'-O-Methyl neochebulinate 1236310-34-1
2,3-Dihydrocalodenin B V87306 2,3-Dihydrocalodenin B 2,3-Dihydrocalodenin B (Compound 6) is a compound isolated from Knema globularia.
2-Hydroxyquinoline V87451 2-Hydroxyquinoline 59-31-4 2-Hydroxyquinoline is a potent inhibitor of α-glucosidase with IC50 values of 64.4 and 130.5 µg/mL for α-glucosidase and α-amylase, respectively.
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one V87472 9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one 204134-70-3 9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and a mixed-competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L).
ACARBOSE V4336 ACARBOSE 56180-94-0 Acarbose (also known as BAY g 5421; trade names: Glucobay; Prandase; Precose) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes by combining with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes.
ACARBOSE SULFATE V4337 ACARBOSE SULFATE 1221158-13-9 Acarbose sulfate (also known as BAY g 5421 sulfate; trade names: Glucobay; Prandase; Precose) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes by combining with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes.
AChE/BChE-IN-17 V84590 AChE/BChE-IN-17
Afegostat D-Tartrate V21265 Afegostat D-Tartrate 957230-65-8 Afegostat D-Tartrate (Isofagomine D-Tartrate, AT2101 D-Tartrate), designed as a pharmacological chaperone, was an experimental drug under investigation for the treatment of certain forms of Gaucher's disease.
Afegostat tartrate (AT 2101; D-Isofagomine tartrate; Isofagomine tartrate) V84506 Afegostat tartrate (AT 2101; D-Isofagomine tartrate; Isofagomine tartrate) 919364-56-0
Antidiabetic agent 5 V87299 Antidiabetic agent 5 Antidiabetic agent 5 (compound S1) is an antidiabetic agent.
Arisanschinin D V87475 Arisanschinin D 1314021-69-6 Arisanschinin D (Ananonin B) is an α-Glucosidase inhibitor isolated from Schisandra arisanensis Hay.
Castanospermine V4943 Castanospermine 79831-76-8 Castanospermine, a novel indolizidine alkaloid first isolated from the seeds of Castanospermum australe, is a potent inhibitor of some glucosidase enzymes and has antiviral activity in vitro and in mouse models.
Chrysin 6-C-arabinoside 8-C-glucoside V51240 Chrysin 6-C-arabinoside 8-C-glucoside 185145-33-9 Chrysin 6-C-arabinoside 8-C-glucoside is an α±-glucosidase inhibitor that is extensively used in type 2 diabetes research.
CID-4694321 V2298 CID-4694321 1462267-08-8 CID-4694321 (also known as ML-266; ML266;CID-4694321) is a novel and potent activator of GCase (glucocerebrosidase) with the potential to be used for treatingGaucher disease.
Conduritol B epoxide V18613 Conduritol B epoxide 6090-95-5 Conduritol B epoxide (formerly known as CBE) is an irreversible/covalent inhibitor of non-mammalian and mammalian β-glucosidase (GCase).
CTL26 V87457 CTL26 CTL26 is a potent and orally active α-glucosidase inhibitor with IC50 of 2.81 µM.
Duvoglustat (1-Deoxynojirimycin) V32050 Duvoglustat (1-Deoxynojirimycin) 19130-96-2 Duvoglustat (Moranoline; deoxynojirimycin;1-Deoxynojirimycin;AT-2220; DNJ) is a novel and potent alpha-glucosidase inhibitorfound in mulberry leaves and hasantihyperglycemic, anti-obesity, and antiviral activities.
Gcase activator 3 V84734 Gcase activator 3 2270984-21-7
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