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TNF Receptor

TNF Receptor

The pathogenesis of a wide range of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases, has been linked to tumor necrosis factor (TNF), a key mediator of apoptosis as well as inflammation and immunity.

TNF- α is a homotrimer in solution and a 17-kDa protein with 157 amino acids. The gene is located on chromosome 6 in humans. Its soluble TNF-binding receptors play a major role in controlling its bioactivity. T lymphocytes, natural killer cells, and activated macrophages are the main producers of TNF-α. Numerous other cells, such as fibroblasts, smooth muscle cells, and tumor cells, are known to have lower expression. TNF- is produced in cells as pro-TNF (26 kDa), which is membrane-bound and is released after TNF-converting enzyme (TACE) cleaves its pro domain.

The two TNF receptors, TNF-R1 and TNF-R2, which are both members of the TNF receptor super-family, mediate many of the cellular responses brought on by TNF. Most cell types respond to TNF treatment by activating the transcription factor NF-B and MAP kinases like ERK, p38, and JNK. In some cases, apoptosis or necrosis may also be induced. However, TNFR1, also referred to as a death receptor, is primarily responsible for the induction of apoptosis or necrosis. Numerous cytokines and immune-regulatory proteins are induced as a result of NF-B and MAPK activation, which is crucial for many inflammatory responses.

TNF Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside V121341 (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside 71129-71-0 (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a cardiac glycoside found in the bark of the yellow oleander (Thevetia peruviana).
(3S)-Tanzisertib hydrochloride V121561 (3S)-Tanzisertib hydrochloride 2517855-91-1 (3S)-Tanzisertib hydrochloride is an orally effective JNK inhibitor (IC50 values of 61, 7 and 6 nM for JNK1, JNK2 and JNK3, respectively).
(S)-Elobixibat V88552 (S)-Elobixibat 439087-68-0 (S)-Elobixibat is the S-isomer of Elobixibat.
(±)-Perillaldehyde V107688 (±)-Perillaldehyde 2111-75-3 (±)-Perillaldehyde has an antidepressant effect on stress-induced depression-like model mice by regulating the olfactory nervous system.
12-Hydroxydehydroabietic acid V123107 12-Hydroxydehydroabietic acid 116032-84-9 12-Hydroxydehydroabietic acid is a diterpenoid compound found in the whole plant of *Ilex yunnanensis*.
12-Nitrolinoleate V123130 12-Nitrolinoleate 774603-05-3 12-Nitrolinoleate is an activator of peroxisome proliferation-activating receptor γ (PPARγ).
2-O-Methyl PAF C-16 V103054 2-O-Methyl PAF C-16 78858-44-3 2-O-MethylPAF C-16 (ET-18-O-OCH3) is a structural analog and cytotoxic ether lipid of the inflammatory mediator platelet-activating factor (PAF).
2-O-Methylatromentin V124853 2-O-Methylatromentin 121254-55-5 2-O-Methylatromentin is an anti-neuroinflammatory drug.
2141-V11 V124354 2141-V11 2923542-55-4 2141-V11 is an anti-CD40 agonist antibody with enhanced FcγRIIB binding ability.
3-O-Caffeoyl-5-O-feruloylquinic acid V109442 3-O-Caffeoyl-5-O-feruloylquinic acid 173658-86-1 3-O-caffeoyl-5-O-feruloylquinic acid is a quinic acid phenolic compound isolated from Mediterranean sea holly (Eryngium bourgatii).
3-苯基-2-异恶唑啉-5-乙酸 V1944 VGX-1027 (GIT 27) 6501-72-0 VGX-1027 (also known as VGX1027; GIT-27)is an orally bioactive,isoxazoline compound with potent immunomodulatory properties by inhibiting the toll-like receptor 4 (TLR4) signaling pathway.
7-O-Galloyl-D-sedoheptulose V114249 7-O-Galloyl-D-sedoheptulose 233690-85-2 7-O-galloyl-D-sedoheptulose is an orally effective polyphenol compound.
8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen V127635 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen 889112-17-8 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen is a compound found in grapefruit (Citrus grandis).
ABI793 V128041 ABI793 ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody.
Abiprubart V128044 Abiprubart 2765071-95-0 Abiprubart is an anti-CD40 human IgG4κ monoclonal antibody.
ADG-106 V128320 ADG-106 ADG-106 is a fully human agonist monoclonal IgG4 antibody that targets CD137 (4-1BB).
AF-45 V88553 AF-45 AF-45 inhibits IRAK4 and IRAK1 with IC50 of 128 nM and 1765 nM, respectively.
Afimkibart V106379 Afimkibart Afimkibart (PF-06480605) is a human IgG1 monoclonal antibody directed against tumor necrosis factor-like ligand 1A (TL1A).
AGEN-2373 V128400 AGEN-2373 AGEN-2373 is a conditional agonist antibody that targets the co-stimulatory receptor CD137.
Akt/NF-κB/MAPK-IN-1 V77871 Akt/NF-κB/MAPK-IN-1 Akt/NF-κB/MAPK-IN-1 (compound 2m) is an orally bioactive NO inhibitor (IC50=7.70 μM) without obvious toxicity.
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