TNF Receptor

TNF Receptor

The pathogenesis of a wide range of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases, has been linked to tumor necrosis factor (TNF), a key mediator of apoptosis as well as inflammation and immunity.

TNF- α is a homotrimer in solution and a 17-kDa protein with 157 amino acids. The gene is located on chromosome 6 in humans. Its soluble TNF-binding receptors play a major role in controlling its bioactivity. T lymphocytes, natural killer cells, and activated macrophages are the main producers of TNF-α. Numerous other cells, such as fibroblasts, smooth muscle cells, and tumor cells, are known to have lower expression. TNF- is produced in cells as pro-TNF (26 kDa), which is membrane-bound and is released after TNF-converting enzyme (TACE) cleaves its pro domain.

The two TNF receptors, TNF-R1 and TNF-R2, which are both members of the TNF receptor super-family, mediate many of the cellular responses brought on by TNF. Most cell types respond to TNF treatment by activating the transcription factor NF-B and MAP kinases like ERK, p38, and JNK. In some cases, apoptosis or necrosis may also be induced. However, TNFR1, also referred to as a death receptor, is primarily responsible for the induction of apoptosis or necrosis. Numerous cytokines and immune-regulatory proteins are induced as a result of NF-B and MAPK activation, which is crucial for many inflammatory responses.

TNF Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V51038 Adalimumab beta (ABP-501) 1446410-95-2 anti-TNF-α monoclonal antibody
V77871 Akt/NF-κB/MAPK-IN-1 Akt/NF-κB/MAPK-IN-1 (compound 2m) is an orally bioactive NO inhibitor (IC50=7.70 μM) without obvious toxicity.
V77782 Anti-inflammatory agent 61 Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent.
V78041 Anti-Mouse 4-1BB Antibody (3H3) Anti-Mouse 4-1BB Antibody is an anti-mouse 4-1BB IgG2a antibody inhibitor developed from host Rat.
V76012 Boserolimab (MK-5890) 2444297-08-7 Boserolimab (MK-5890) is a chimeric humanized IgG1κ antibody targeting the mouse signaling regulatory protein CD27.
V51081 Broussonin E 90902-21-9 anti-inflammatory agent
V79207 DPP-4-IN-8 DPP-4-IN-8 (compound 27) is a potent and specific DPP4 inhibitor (antagonist) with Ki of 0.96 μM.
V77066 DRI-C21041 (DIEA) DRI-C21041 DIEA is a CD40/CD40L interaction inhibitor (antagonist) with IC50 of 0.31 μM.
V77055 DSTYSLSSTLTLSK TFA DSTYSLSSTLTLSK TFA is a human universal peptide that can be used for quantitative detection of infliximab.
V74915 EM-163 1206480-93-4 EM-163 is a synthetic BB-Loop analog.
V76011 Evunzekibart (ATOR-1017) 2639688-77-8 Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody.
V76013 Exlinkibart (LVGN-6051) 2642171-64-8 Exlinkibart (LVGN-6051) targets TNFRSF9 and is an IgG1κ antibody humanized through complementarity determining region (CDR) grafting technology.
V77017 Fisetin quarterhydrate (fisetin) Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables that has multiple benefits such as antioxidant, anti-cancer, and neuro-protection effects.
V76924 HMGB1-IN-1 HMGB1-IN-1 (compound 6) displays strong NO inhibition in RAW264.7 cells with IC50 of 15.9 ± 0.6 μM.
V51554 Isodorsmanin A 118266-99-2 anti-inflammatory agent
V76829 LEESGGGLVQPGGSMK acetate LEESGGGLVQPGGSMK acetate, a proteolytic peptide that is a component of Infliximab, may be utilized in the quantitative analysis of Infliximab.
V80550 LEESGGGLVQPGGSMK TFA LEESGGGLVQPGGSMK TFA, a proteolytic peptide, is a component of Infliximab and can be used for quantitative analysis of Infliximab.
V76822 Licaminlimab (OCS-02) Licaminlimab (OCS-02) is a single-chain anti-TNF alpha antibody fragment.
V51045 Loganic acid 6′-O-β-D-glucoside 176226-39-4 Loganic acid 6′-O-β-D-glucoside is an irisin extracted from Gentiana rhodantha.
V51052 Mulberroside D (cis-Mulberroside A) 166734-06-1 anti-inflammatory agent
Contact Us Back to top