Activator Protein 1 (AP-1) is not a single protein, but a collective term referring to dimeric transcription factors composed of Jun (c-Jun, JunB, JunD), Fos (c-Fos, FosB, Fra-1, Fra-2) ATF (activating transcription factor, ATF-2, ATF-3/LRF1, ATF-4, ATF-5, ATF-6B, ATF-7, BATF, BATF-2, BATF-3, JDP2) or MAF (c-MAF, MafA, MafB, MafF, MafG, MafK and Nrl) subunits that bind to a common DNA site, the AP-1-binding site. Many different cellular and physiological processes involve AP-1.
It is acknowledged as a master integrator of a myriad of extracellular signals allowing cells to adapt to changes in their environment. AP-1 has also been implicated in various severe diseases. These include transplant rejection, fibrosis, organ injury and a variety of inflammatory pathologies such as rheumatoid arthritis, asthma and psoriasis. In addition, cancer is undoubtedly the most documented pathology involving AP-1 where its activity is often dysregulated and contributes to cell transformation, tumor progression, aggressiveness and resistance to treatments.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51074 | (+)-Glaucarubinone | 1259-86-5 | (+)-Glaucarubinone is a potent inhibitor of activator protein-1 (AP-1) with EC50 of 0.13 µM. |
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V88949 | 15(S)-HPETE | 70981-96-3 | 15(S)-HpETE is a monohydroperoxypolyunsaturated fatty acid (PUFA) produced by 15-lipoxygenase (15-LO) on arachidonic acid. |
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V74744 | Fas C-Terminal Tripeptide | 189109-90-8 | Fas C-Terminal Tripeptide is the C-terminal tripeptide of Fas protein. |
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V41511 | SR-11302 | 160162-42-5 | SR-11302 (SR11302) is an AP-1 (activator protein-1) transcription factor inhibitor withantitumor activity. |
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V2895 | T-5224 | 530141-72-1 | T-5224 is a novel and selective inhibitor of c-Fos/activator protein-1 (AP-1) which is a transcriptional factor that regulates the expression of various genes associated with tumor invasion and migration. |
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V51071 | Chloranthalactone B | 66395-03-7 | Chloranthalactone B is an indanane-type sesquiterpenoid, a naturally occurring compound that can be extracted from Herba Coral by distillation. |
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