TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells.The mature immune, nervous, and reproductive systems depend on the TAM family of receptors and their ligands, Gas6 and Protein S (PROS1), for the best phagocytosis of apoptotic cells.
Three homologous type I receptor-tyrosine kinases known as TAMs are triggered by PROS1 and GAS6, two endogenous ligands. These ligands can either act as soluble factors to activate TAMs or act as connecting molecules between TAMs and apoptotic cells (ACs) by opsonizing phosphatidylserine (PS) on ACs. Cancer cell survival and proliferation as well as the suppression of anti-tumor immunity have been linked to abnormal TAM expression and activation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V14260 | RU-301 | 1110873-99-8 | RU-301 is a novel pan-tam inhibitor, that exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively. |
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V37620 | Tamnorzatinib (ONO-7475) | 1646839-59-9 | ONO-7475 is a novel and orally bioactive dual Axl/Mer inhibitor with anticancer activity by targeting both Axl and Mer, and preventing their activity. |
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