Protein kinase D (PKD) is an evolutionarily conserved protein kinase family that differs from the PKC family members in terms of its structural, enzymological, and regulatory characteristics. A staggering array of stimuli, such as G-protein-coupled receptor agonists and polypeptide growth factors, can cause signaling through PKD. Three serine/threonine protein kinases make up the PKD family: PKD1, PKD2, and PKD3. A growing number of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer, are being linked to PKD1, the most studied member of the family. Through dynamic shifts in its spatial and temporal localization as well as its distinctive substrate specificity, PKD mediates such a broad range of both normal and abnormal biological functions.
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