Thrombin is a Na+-activated, serine protease that is activated by activated Factor X's enzymatic cleavage of two sites on prothrombin. Two allosteric forms of thrombin, slow (S) and fast (F), are focused on procoagulant and anticoagulant activities, respectively.
By activating platelets, thrombin is the primary effector protease in primary hemostasis and is essential for secondary hemostasis. In addition to its well-known roles in hemostasis, thrombin also contributes to a number of biological and pathophysiologic processes that are not hemostatic, most of which are mediated by the activation of protease-activated receptors (PARs). Thrombin cleaves PAR-1, PAR-3, and PAR-4 whereas trypsin cleaves PAR-2. Additionally, thrombin is essential for the migration and metastasis of human cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V111537 | (21R)-Argatroban | 121785-71-5 | (21R)-Agatroban is a diastereomer of agatroban. |
|
V110960 | (2S,4S)-Argatroban | 189264-03-7 | (2S,4S)-Argatroban ((2S,4S)-MD-805) (compound 1c) is a human thrombin inhibitor with a Ki value of 280 μM. |
|
V119710 | 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol | 127994-00-7 | 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol (compound 2e) is a diacylglycerol derivative that can be isolated from the fungus *Stereum hirsutum*. |
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V71925 | 15,16-Dihydrotanshindiol C (15,16-Dihydrotanshindiol C) | 891854-96-9 | 15,16-Dihydrotanshindiol C is a diterpenoid and a potent thrombin inhibitor. |
|
V94287 | Atecegatran TFA | 433937-75-8 | Artigatran TFA (AR-H067637 TFA) is an anticoagulant with selective direct thrombin inhibitory activity. |
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V71920 | BAY 1217224 | 1639886-32-0 | BAY 1217224 is a neutral non-precursor inhibitor of Thrombin with good oral pharmacokinetics. |
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V114261 | Corthrombin | 166247-65-0 | Corthrombin (CVS 995) is a potent α-ketoamide thrombin inhibitor with a Ki value of 1 pM. |
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V114888 | CVS-1123 | 151275-19-3 | CVS-1123 is an orally effective direct thrombin inhibitor. |
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V71924 | Dabigatran-13C6 (BIBR 953-13C6; BIBR 953ZW-13C6) | 1210608-88-0 | Dabigatran-13C6 is 13C (carbon 13)-labeled Dabigatran. |
|
V71927 | Dabigatran-d3 (BIBR 953-d3; BIBR 953ZW-d3) | 1246817-44-6 | Dabigatran-d3 is the deuterium labelled form of Dabigatran. |
|
V77109 | Dabigatran-d4 hydrochloride (Dabigatran D4 hydrochloride; BIBR-953-d4 hydrochloride) | Dabigatran-d4 ( HCl) is the deuterated form of Dabigatran. | |
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V85751 | Dermatan sulphate sodium (Chondroitin B sulfate) | 54328-33-5 | |
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V116266 | DS-1040 | 1335138-62-9 | DS-1040 is a low molecular weight imidazole derivative. |
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V94230 | Efegatran di(hydrochloride) | 173006-83-2 | Efegatran (LY 294468) dihydrochloride is a thrombin inhibitor that inhibits platelet aggregation and exerts anticoagulant and antithrombotic effects. |
|
V114588 | FK 633 | 147865-49-4 | FK 633 (FR-144633) is a fibrinogen inhibitor and a peptide mimic GPIIbIIa receptor antagonist. |
|
V117380 | FXIIa-IN-1 hydrochloride | 3052551-20-6 | FXIIa-IN-1 hydrochloride is the hydrochloride salt of FXIIa-IN-1. |
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V87737 | FXIIa-IN-5 | FXIIa-IN-5 (Compound 4J) is an orally available, selective inhibitor of factor XIIa (FXIIa) with IC50 of 21 nM. | |
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V71916 | Hirullin P18 | 131147-81-4 | Hirullin P18 is a potent thrombin inhibitor. |
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V87738 | Idrabiotaparinux | 774531-07-6 | Idrabiotaparinux is a derivative of Idraparinux, a new synthetic anticoagulant that links the specific indirect factor Xa inhibitor Idraparinux to biotin. |
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V117233 | Idrabiotaparinux sodium | 405159-59-3 | Idabioheparin sodium is a derivative synthesized from idaheparin and biotin. |
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