Thrombin is a Na+-activated, serine protease that is activated by activated Factor X's enzymatic cleavage of two sites on prothrombin. Two allosteric forms of thrombin, slow (S) and fast (F), are focused on procoagulant and anticoagulant activities, respectively.
By activating platelets, thrombin is the primary effector protease in primary hemostasis and is essential for secondary hemostasis. In addition to its well-known roles in hemostasis, thrombin also contributes to a number of biological and pathophysiologic processes that are not hemostatic, most of which are mediated by the activation of protease-activated receptors (PARs). Thrombin cleaves PAR-1, PAR-3, and PAR-4 whereas trypsin cleaves PAR-2. Additionally, thrombin is essential for the migration and metastasis of human cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71925 | 15,16-Dihydrotanshindiol C (15,16-Dihydrotanshindiol C) | 891854-96-9 | 15,16-Dihydrotanshindiol C is a diterpenoid and a potent thrombin inhibitor. |
|
V71920 | BAY 1217224 | 1639886-32-0 | BAY 1217224 is a neutral non-precursor inhibitor of Thrombin with good oral pharmacokinetics. |
|
V71919 | Befovacimab (BAY 1093884) | 2156634-62-5 | Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody that binds tissue factor pathway inhibitor (TFPI). |
|
V9487 | Bivalirudin TFA salt | 128270-60-0 | Bivalirudin, a peptide anticoagulant, is a direct thrombin inhibitor and can be used for anticoagulation in invasive heart disease, especially in percutaneous coronary intervention. |
|
V4932 | Dabigatran ethyl ester | 429658-95-7 | Dabigatran ethyl ester is the ethyl ester form of dabigatran which is an antithrombotic drug used to treat blood clot. |
|
V31684 | Dabigatran ethyl ester hydrochloride | 211914-50-0 | Dabigatran ethyl ester HCl is the hydrochloride salt ofDabigatran ethyl ester which is the ethyl ester form of dabigatran. |
|
V71924 | Dabigatran-13C6 (BIBR 953-13C6; BIBR 953ZW-13C6) | 1210608-88-0 | Dabigatran-13C6 is 13C (carbon 13)-labeled Dabigatran. |
|
V71927 | Dabigatran-d3 (BIBR 953-d3; BIBR 953ZW-d3) | 1246817-44-6 | Dabigatran-d3 is the deuterium labelled form of Dabigatran. |
|
V77109 | Dabigatran-d4 hydrochloride (Dabigatran D4 hydrochloride; BIBR-953-d4 hydrochloride) | Dabigatran-d4 ( HCl) is the deuterated form of Dabigatran. | |
|
V28838 | Heparin Lithium salt | 9045-22-1 | Heparin Lithium salt is an anticoagulant that binds reversibly to antithrombin III (ATIII). |
|
V28840 | Heparin sodium salt (MW 15kDa) | 9041-08-1 | Heparin sodium salt (MW 15kDa),a polymerized Heparin with a molecular weight of 15kDa,is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. |
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V71916 | Hirullin P18 | 131147-81-4 | Hirullin P18 is a potent thrombin inhibitor. |
|
V2114 | Metolazone (SR-720-22) | 17560-51-9 | Metolazone (SR-720-22), a thiazide-like diuretic, is mainly used to treat CHF-congestive heart failure and HBP-high blood pressure. |
|
V71928 | Rovunaptabin (ARC 183) | 145563-68-4 | Rovunaptabin (ARC 183) is a nucleic acid aptamer, a single-stranded DNA molecule consisting of 15 deoxynucleotides, forming a clear three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity. |
|
V71922 | Sar-Pro-Arg-pNA | 77695-30-8 | Sar-Pro-Arg-pNA is a chromogenic substrate for α-thrombin. |
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V71915 | TFLLRNPNDK-NH2 | 145229-90-9 | TFLLRNPNDK-NH2 is a biologically active peptide. |
|
V71923 | Thrombin inhibitor 6 | 1628224-94-1 | Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50= 1 nM). |
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V71926 | Thrombin receptor peptide ligand | 287964-20-9 | Thrombin receptor peptide ligand is a thrombin receptor blocker (antagonist) peptide that works as an antithrombotic agent. |
|
V71921 | Z-Gly-Pro-Arg-4MβNA | 66647-41-4 | Z-Gly-Pro-Arg-4MβNA is a cleavage product of the thrombin substrate, releasing free 4-methoxy-2-naphthylamine (4MβNA). |
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