Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus.Thyroid hormone (T3)-mediated biological activities are mediated by thyroid hormone receptors, ligand-dependent transcription factors. Two genes, one for TR and the other for TR, encode the primary isoforms of thyroid hormone receptors, including TR1, TR2, TR1, and TR2. The pleiotropic effects of the thyroid hormone (T3) on growth, development, and differentiation as well as the preservation of metabolic equilibrium are mediated by the thyroid hormone receptors.
Thyroid hormone receptors are zinc finger transcription factors belonging to the erbA superfamily that bind to DNA at particular response element sequences called TREs and trigger gene expression in response to thyroid hormone (T3). It has been demonstrated that thyroid hormone receptors can form monomers, homodimers, or heterodimers with the retinoid X receptor (RXR), another member of the erbA superfamily, to bind DNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67826 | 1α-Hydroxy-3-epi-vitamin D3 | 58028-00-5 | 1α-Hydroxy-3-epi-vitamin D3 is a natural metabolite of 1α, 25-dihydroxyvitamin D3 and an inhibitor (blocker/antagonist) of parathyroid hormone (PTH) secretion. |
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V3920 | ABALOPARATIDE | 247062-33-5 | Abaloparatide (Trade name Tymlos; formerly known as BA-058; ITM-058; BIM 44058) is a 34 amino acid synthetic analog of parathyroid hormone-related protein (PTHrP) that is used to treat osteoporosis. |
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V77309 | Abaloparatide TFA (Abaloparatide; BA 058 TFA; BIM 44058 TFA) | Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 PTHR1 analog. | |
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V67812 | Biotin-(L-Thyroxine) | 149734-00-9 | Biotin-(L-Thyroxine) is biotinylated L-Thyroxine. |
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V67815 | Debutyldronedarone hydrochloride (SR35021 hydrochloride) | 197431-02-0 | Debutyldronedarone (SR35021) HCl, the major metabolite of Dronedarone, is a selective thyroid hormone receptor alpha 1 (TRα1) inhibitor. |
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V67819 | DPC-AJ1951 | 943519-33-3 | DPC-AJ1951, a 14-amino-acid peptide, works as a potent agonist of parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) and functions in ex vivo and in vivo bone resorption assays. |
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V77069 | DPC-AJ1951 TFA | DPC-AJ1951 TFA, a 14-amino acid (AA) peptide, works as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) and functions in ex vivo and in vivo bone resorption assays. | |
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V67817 | DS08210767 | 2376334-75-5 | DS08210767 is a potent, bioavailable orally bioavailable PTHR1 antagonist (inhibitor) with IC50 of 90 nM. |
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V77064 | DS69910557 | DS69910557 is a specific, orally bioactive human parathyroid hormone receptor 1 (hPTHR1) antagonist. | |
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V83222 | Eneboparatide | 1349298-00-5 | Eneboparatide (AZP-3601) is a 36 amino-acid PTH analog that acts as a parathyroid hormone receptor 1 (PTHR1) agonist. |
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V76969 | Glutaurine TFA (Litoralon TFA) | Glutaurine (Litoralon) TFA contains glutamine and taurine residues and is an orally bioactive hormone of the parathyroid gland. | |
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V29928 | L-Thyroxine sodium salt pentahydrate | 6106-07-6 | L-Thyroxine sodium salt pentahydrate is an endogenous iodine-bearing thyroid hormone produced from thyroglobulin in the thyroid follicular cells. |
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V67829 | L-Thyroxine-13C6 (L-Thyroxine-13C6) | 720710-30-5 | L-Thyroxine-13C6 is 13C (carbon 13) labelled L-Thyroxine. |
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V30180 | Liothyronine sodium | 55-06-1 | Liothyronine sodium is a potent thyroid hormone. |
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V67824 | Liothyronine-13C6-1 (Triiodothyronine-13C6; Triiodothyronine-13C6-1; 3,3',5-Triiodo-L-thyronine-13C6-1; T3-13C6-1) | 1213431-76-5 | Liothyronine-13C6-1 is a 13C (carbon 13)-labeled Liothyronine. |
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V67818 | Liothyronine-13C9,15N (Triiodothyronine-13C9,15N; 3,3',5-Triiodo-L-thyronine-13C9,15N; T3-13C9,15N) | 1213569-04-0 | Liothyronine-13C9,15N is 13C (carbon 13) and 15N (nitrogen 15) labelled liothyronine. |
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V67814 | NH-3 | 447415-26-1 | NH-3 is an orally bioactive, reversible thyroid hormone receptor (THR) antagonist (inhibitor) with IC50 of 55 nM. |
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V67828 | Osteostatin (human) (Human PTHrP(107-139)) | 137348-10-8 | Osteostatin (human) is a 107-139 fragment of parathyroid hormone-related protein (PTHrP) that promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis. |
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V76659 | Parathyroid hormone (1-34) (rat) acetate | Parathyroid hormone (1-34) (rat) (acetate) is parathyroid hormone. | |
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V81042 | Parathyroid Hormone (1-34), bovine TFA | Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. |
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