| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1341 | BMS-833923 (XL-139) | 1059734-66-5 | BMS-833923 (also known as XL139; BMS833923; XL-139; BMS 833923) is a novel, potent, selective, andorally bioavailable inhibitor of SMO (Smoothened) with potential antineoplastic activity. |
|
V1332 | Cyclopamine (11-Deoxojervine) | 4449-51-8 | Cyclopamine (formerly HSDB3505; HSDB-3505; 11-deoxojervine),a naturally occuring steroid alkaloid found in Veratrum plant, is reported to be a potent and specific inhibitor of Hedgehog (Hh) signaling pathway with both anticancer and teratogenic activities. |
|
V1337 | GANT61 | 500579-04-4 | GANT61 (GANT 61; nsc 136476; GANT-61; nsc-136476) is a novel and potent small-molecule inhibitor for GLI1 (glioma-associated oncogene 1) and GLI2-induced transcription with potential anticancer activity. |
|
V1339 | Glasdegib (PF-04449913) | 1095173-27-5 | Glasdegib (formerly known as PF-04449913; PF4449913; PF04449913; PF-4449913; Daurismo) is a novel, potent, and orally bioavailable small-molecule inhibitor of Smoothened (Smo) in the Hedgehog (Hh) signaling pathway with potential antitumor activity. |
|
V69865 | Hedgehog IN-2 | 1126365-74-9 | Hedgehog IN-2 (Compound 20) is a Hedgehog pathway inhibitor (antagonist) with IC50 of less than 0.003 μM in C3H10T1/2 cells. |
|
V69864 | Hedgehog IN-3 | 1128191-09-2 | Hedgehog IN-3 (Compound 3) is a hedgehog pathway inhibitor (IC50 = 0.01 µM). |
|
V69860 | Hedgehog IN-5 | 1544681-93-7 | Hedgehog IN-5 is an orally bioactive small molecule inhibitor of the hedgehog pathway. |
|
V1333 | LDE225 (NVP-LDE225, Erismodegib) | 956697-53-3 | Erismodegib (formerly LDE-225; NVP LDE-225; LDE225; NVP-LDE22; Sonidegib; trade name of Odomzo) is an orally bioavailable small-molecule antagonist of the Smoothened (Smo) in Hedgehog signaling pathway with potential antitumor activity. |
|
V1336 | PF-5274857 | 1373615-35-0 | PF-5274857 (PF5274857; PF 5274857) is a novel, potent, orally bioavailable and selective Smoothened (Smo) antagonist with potential antineoplastic activity. |
|
V1335 | Purmorphamine | 483367-10-8 | Purmorphamine (also called Shh Signaling Antagonist VI) is a potentpurine-based agonist ofthe hedgehog signaling pathway-smoothened receptor with an EC50of 1 μM. |
|
V69135 | RL-0070933 | 301326-41-0 | RL-0070933 is an effective ciliary regulator. |
|
V69861 | RU-SKI 43 hydrochloride (RU-SKI 43 (hydrochloride)) | 1782573-67-4 | RU-SKI 43 HCl is a potent and specific inhibitor of hedgehog acyltransferase (Hhat) with IC50 of 850 nM. |
|
V69863 | SANT 2 | 329196-48-7 | SANT 2 is a potent antagonist of the Hh signaling pathway. |
|
V1340 | SANT-1 | 304909-07-7 | SANT-1 (SANT1; SANT 1) is a novel, potent and selective Sonic hedgehog (Shh) enzyme inhibitor/Smo antagonist with potential antineoplastic activity. |
|
V1338 | Smoothened Agonist (SAG) | 912545-86-9 | Smoothened Agonist (SAG), a benzothiophene analog, is a potent and cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
|
V1334 | Taladegib (LY2940680) | 1258861-20-9 | Taladegib (formerly LY2940680, LY 2940680, LY-2940680) is a potent and orally bioavailable Hedgehog pathway antagonist of the smoothened receptor being developed by Eli Lilly for the treatment of cancer. |
|
V1331 | Vismodegib (GDC-0449) | 879085-55-9 | Vismodegib (formerly known as GDC-0449; RG-3616; GDC0449; RG3616; trade name: Erivedge) is a potent, orally bioavailable, first-in-class and specific hedgehog pathway inhibitor with potential anticancer activity. |
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