Hedgehog(Smoothened) ROCK

Hedgehog(Smoothened) ROCK

Hedgehog(Smoothened) ROCK related products

Structure Cat No. Product Name CAS No. Product Description
V1341 BMS-833923 (XL-139) 1059734-66-5 BMS-833923 (also known as XL139; BMS833923; XL-139; BMS 833923) is a novel, potent, selective, andorally bioavailable inhibitor of SMO (Smoothened) with potential antineoplastic activity.
V1332 Cyclopamine (11-Deoxojervine) 4449-51-8 Cyclopamine (formerly HSDB3505; HSDB-3505; 11-deoxojervine),a naturally occuring steroid alkaloid found in Veratrum plant, is reported to be a potent and specific inhibitor of Hedgehog (Hh) signaling pathway with both anticancer and teratogenic activities.
V1337 GANT61 500579-04-4 GANT61 (GANT 61; nsc 136476; GANT-61; nsc-136476) is a novel and potent small-molecule inhibitor for GLI1 (glioma-associated oncogene 1) and GLI2-induced transcription with potential anticancer activity.
V1339 Glasdegib (PF-04449913) 1095173-27-5 Glasdegib (formerly known as PF-04449913; PF4449913; PF04449913; PF-4449913; Daurismo) is a novel, potent, and orally bioavailable small-molecule inhibitor of Smoothened (Smo) in the Hedgehog (Hh) signaling pathway with potential antitumor activity.
V69865 Hedgehog IN-2 1126365-74-9
V69864 Hedgehog IN-3 1128191-09-2
V69860 Hedgehog IN-5 1544681-93-7
V1333 LDE225 (NVP-LDE225, Erismodegib) 956697-53-3 Erismodegib (formerly LDE-225; NVP LDE-225; LDE225; NVP-LDE22; Sonidegib; trade name of Odomzo) is an orally bioavailable small-molecule antagonist of the Smoothened (Smo) in Hedgehog signaling pathway with potential antitumor activity.
V1336 PF-5274857 1373615-35-0 PF-5274857 (PF5274857; PF 5274857) is a novel, potent, orally bioavailable and selective Smoothened (Smo) antagonist with potential antineoplastic activity.
V1335 Purmorphamine 483367-10-8 Purmorphamine (also called Shh Signaling Antagonist VI) is a potentpurine-based agonist ofthe hedgehog signaling pathway-smoothened receptor with an EC50of 1 μM.
V69135 RL-0070933 301326-41-0
V69861 RU-SKI 43 hydrochloride (RU-SKI 43 (hydrochloride)) 1782573-67-4
V69863 SANT 2 329196-48-7
V1340 SANT-1 304909-07-7 SANT-1 (SANT1; SANT 1) is a novel, potent and selective Sonic hedgehog (Shh) enzyme inhibitor/Smo antagonist with potential antineoplastic activity.
V1338 Smoothened Agonist (SAG) 912545-86-9 Smoothened Agonist (SAG), a benzothiophene analog, is a potent and cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
V1334 Taladegib (LY2940680) 1258861-20-9 Taladegib (formerly LY2940680, LY 2940680, LY-2940680) is a potent and orally bioavailable Hedgehog pathway antagonist of the smoothened receptor being developed by Eli Lilly for the treatment of cancer.
V1331 Vismodegib (GDC-0449) 879085-55-9 Vismodegib (formerly known as GDC-0449; RG-3616; GDC0449; RG3616; trade name: Erivedge) is a potent, orally bioavailable, first-in-class and specific hedgehog pathway inhibitor with potential anticancer activity.
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