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BTK

BTK

Btk, a member of the Tec family of kinases, is well-known for its function in B-cell activation and B-cell antigen receptor (BCR) signaling.

Btk is a new target for diseases with abnormal B cell activity because it is essential for B cell development and activation through the BCR signaling pathway. The human primary immune deficiency disease X-linked agammaglobulinemia (XLA), which is caused by a mutation in the Btk gene, highlights the importance of Btk, a kinase that is only expressed in B cells and myeloid cells.The BCR signaling pathway depends on Btk in many ways. B cell receptor oligomerization, Syk and Lyn kinase activation, and Btk kinase activation are all caused by antigen binding to the BCR. When Btk is activated, it joins forces with proteins like BLNK, Lyn, and Syk to form a signaling complex that phosphorylates phospholipase C (PLC)2. This results in transcriptional changes that promote B cell survival, proliferation, and/or differentiation by releasing intracellular Ca2+ stores downstream and propagating the BCR signaling pathway through extracellular signal-regulated kinase and NF-B signaling.

BTK related products

Structure Cat No. Product Name CAS No. Product Description
(R)-Acalabrutinib V87996 (R)-Acalabrutinib 1952316-43-6 (R)-Acalabrutinib ((R)-ACP-196) is an isomer of Acalabrutinib.
(R)-NX-2127 V87995 (R)-NX-2127 3024312-52-2 (R)-NX-2127 (compound 28) is an orally active Bruton's tyrosine kinase (Btk) degrader.
(R,R)-Bexobrutideg V115563 (R,R)-Bexobrutideg 2649400-33-7 (R,R)-Bexobrutideg is the (R,R)-enantiomer of bexobrutideg.
(R,R)-Birelentinib V109231 (R,R)-Birelentinib 2662512-14-1 (R,R)-Birelentinib ((R,R)-DZD8586) (compound 14) is a potent BTK inhibitor with IC50 values of 0.7 nM for wild-type BTK and 0.86 nM for BTK C481S mutant.
(Rac)-Ibrutinib alkyne V119798 (Rac)-Ibrutinib alkyne 936563-91-6 (Rac)-ibrutinib alkyne (compound 8) is a Btk inhibitor with an IC50 of 0.72 nM.
(Z)-LFM-A13 V0647 (Z)-LFM-A13 244240-24-2 (Z)-LFM-A13 (LFM-A1-3) is a novel, potent and specific Brutons tyrosine kinase (BTK) inhibitor with potential anticancer activity.
ABBV-992 V89055 ABBV-992 2792171-84-5 ABBV-992 is a potent and selective BTK inhibitor.
Acalabrutinib maleate V108927 Acalabrutinib maleate 2242394-65-4 Acalatinib maleate is an orally effective, irreversible, and highly selective second-generation BTK inhibitor.
BIIB129 V87994 BIIB129 2770960-52-4 BIIB129 is a covalent, selective, blood-brain barrier-penetrating small molecule inhibitor of Bruton's tyrosine kinase (BTK).
BTK C481R Recombinant Human Active Protein Kinase V118843 BTK C481R Recombinant Human Active Protein Kinase Bruton's tyrosine kinase (BTK) plays a key role in the B cell antigen receptor (BCR) signaling pathway.
BTK degrader-2 V114529 BTK degrader-2 2649400-05-3 BTK degrading enzyme-2 (Example 2) is a bifunctional BTK degrading enzyme that degrades BTK via the ubiquitin-proteasome pathway.
BTK inhibitor 27 V5248 BTK inhibitor 27 2230724-66-8 BTK inhibitor 27, compound 27 in the cited reference below, is apyrrolo[2,3-d]pyrimidine based BTK inhibitor with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
BTK ligand 16 V119634 BTK ligand 16 BTK ligand 16 is a BTK ligand that can be used to synthesize TQ-3959.
Btk substrate peptide V99657 Btk substrate peptide The Btk substrate peptide is a peptide substrate corresponding to residues 217-229 of human Bruton's tyrosine kinase (Btk), of which the tyrosine at residue 223 is the major autophosphorylation site of Btk.
BTK V416L Recombinant Human Active Protein Kinase V118856 BTK V416L Recombinant Human Active Protein Kinase Bruton's tyrosine kinase (BTK) plays a key role in the B cell antigen receptor (BCR) signaling pathway.
BTK-IN-21 V111857 BTK-IN-21 2170788-98-2 BTK-IN-21 (compound 12) is a BTK inhibitor with an IC50 of 33 nM.
BTK-IN-36 V87993 BTK-IN-36 2502301-31-5 BTK-IN-36 (S-016) is a BTK inhibitor with IC50 of 0.5 nM.
BTK-IN-38 V93724 BTK-IN-38 2758410-51-2 BTK-IN-38 (Example 125) is a potent BTK inhibitor.
BTK-IN-40 V104977 BTK-IN-40 1791400-83-3 BTK-IN-40 (Compound 375) is an inhibitor of BTK.
BTK-IN-45 V110797 BTK-IN-45 BTK-IN-45 (compound 6b) is a potent, reversible, and selective BTK inhibitor with an IC50 value of 1.14 μM.
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