PDK-1 (3-phosphoinositide-dependent protein kinase 1) is a Ser/Thr protein kinase and a member of the protein A, G, and C (AGC) family. Through phosphorylation and subsequent activation of a number of other AGC kinase family members, such as protein kinase B, PDK-1, the key node in the PI3K pathway, plays a crucial role in insulin and growth-factor signaling.
The control of cell proliferation and migration is handled by PDK-1, which has also been linked to a number of cancers, including pancreatic and breast cancer. Activation of PDK-1 targets like Akt, S6K (p70 ribosomal S6 kinase), and SGK is caused by a number of cancer-causing mutations. As a result, PDK1 has attracted a lot of interest as a potential target for oncology drugs because it is a key activator of numerous pro-survival and oncogenic protein kinases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70260 | BX-320 | 702676-93-5 | BX-320 is a selective, ATP-competitive, orally bioavailable direct PDK1 inhibitor (antagonist) with IC50 of 30 nM. |
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V0235 | BX-795 | 702675-74-9 | BX795 is a novel, potent and selective/specific PDK-1 (3-phosphoinositide-dependent kinase-1) inhibitor with potential antitumor activity. |
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V0236 | BX-912 | 702674-56-4 | BX912 (BX-912) is a novel, potent and specific inhibitor of PDK-1 (phosphoinositide-dependent kinase 1) inhibitor with potential antitumor activity. |
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V0237 | GSK2334470 | 1227911-45-6 | GSK2334470 (GSK-2334470) is a novel, highly specific and potent inhibitor of PDK1 (3-phosphoinositide-dependent protein kinase) with potential antitumor activity. |
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V0234 | OSU-03012 (AR-12) | 742112-33-0 | OSU-03012 (also called AR12), acelecoxib derivative without COX-2 inhibitory activity, is an orally bioavailable, specific, and potent inhibitor of recombinant PDK-1 (3-phosphoinositide-dependent kinase-1) with potential antitumor activity. |
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V81062 | PDKtide | PDKtide is a biologically active peptide. | |
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V70261 | PKD-IN-1 dihydrochloride | 2308510-39-4 | PKD-IN-1 di-HCl (compound 32) is an aminoethylamine aryl (AEAA) compound that works as a PKD-1 inhibitor. |
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