Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.

Topoisomerase related products

Structure Cat No. Product Name CAS No. Product Description
V78993 (1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f)
V55245 (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) 2938875-54-6
V55246 (4-NH2)-Exatecan 2495742-21-5
V3121 (±)-10-Hydroxycamptothecin 64439-81-2 10-Hydroxycamptothecin, a naturally occuring indole alkaloid isolated from Camptotheca acuminate, is a cell-permeable and potent inhibitor of topoisomerase I.
V56564 12-Ethyl-9-hydroxycamptothecin 119577-28-5
V55247 9-Chloromethyl-10-hydroxy-11-F-Camptothecin 2414594-22-0
V78289 AHr
V4150 Aldoxorubicin (INNO-206) 1361644-26-9 Aldoxorubicin (MC-DOXHZN; INNO206, Doxo-EMCH, INNO-206) is an albumin-binding prodrug of doxorubicin, which is a DNA topoisomerase II inhibitor and anthracycline antibiotic anticancer drug.
V4149 Aldoxorubicin HCl (INNO-206) 480998-12-7 Aldoxorubicin HCl (formerly MC-DOXHZN; INNO-206; Doxo-EMCH; INNO206), the hydrochloride salt ofAldoxorubicin, is a albumin-binding prodrug of doxorubicin (an anthracycline antibiotic anticancer drug, and a DNA topoisomerase II inhibitor).
V52397 ARN-21934 2230854-93-8
V52396 ARN24139 2699768-78-8
V56570 Belotecan-d7 hydrochloride (belotecan d7 hydrochloride) 1346598-22-8
V3352 Bimolane 74550-97-3 Bimolane (also known asAT-1727) is a novel, potent topoisomerase II inhibitor that has been widely used for the treatment of cancer, psoriasis, and uveitis in humans.
V12770 Bisantrene HCl (CL-216942, NSC-337766) 71439-68-4 Bisantrene HCl (CL216942 and NSC337766), the hydrochloride salt ofBisantrene, is potent inhibitor of topoisomerase II and DNA intercalators with anticancer activity.
V52261 CH-0793076 TFA (TP3076 TFA) 2740278-76-4
V55708 CL2-MMT-SN38 1084888-82-3
V52199 Datopotamab deruxtecan (DS-1062; Dato-DXd) 2238831-60-0
V3828 Ellipticine 519-23-3 Ellipticine, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP).
V3829 Ellipticine HCl 5081-48-1 Ellipticine HCl, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP).
V55709 Elomotecan hydrochloride (BN 80927) 220997-99-9
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