Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78993 | (1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) | (1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate. | |
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V55245 | (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) | 2938875-54-6 | (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate . |
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V55246 | (4-NH2)-Exatecan | 2495742-21-5 | (4-NH2)-Exatecan is a topoisomerase inhibitor analogue that may be utilized in the synthesis/preparation of active molecules for antibody conjugation (ADC). |
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V3121 | (±)-10-Hydroxycamptothecin | 64439-81-2 | 10-Hydroxycamptothecin, a naturally occuring indole alkaloid isolated from Camptotheca acuminate, is a cell-permeable and potent inhibitor of topoisomerase I. |
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V56564 | 12-Ethyl-9-hydroxycamptothecin | 119577-28-5 | 12-Ethyl-9-hydroxycamptothecin is an analogue of Camptothecin. |
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V55247 | 9-Chloromethyl-10-hydroxy-11-F-Camptothecin | 2414594-22-0 | 9-Chloromethyl-10-Hydroxy-11-F-Camptothecin? is a new camptothecin analogue. |
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V78289 | AHr | AuM1Phe is an N-heterocyclic carbene (NHC) metal complex that blocks human topoisomerase I activity and actin polymerization. | |
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V4150 | Aldoxorubicin (INNO-206) | 1361644-26-9 | Aldoxorubicin (MC-DOXHZN; INNO206, Doxo-EMCH, INNO-206) is an albumin-binding prodrug of doxorubicin, which is a DNA topoisomerase II inhibitor and anthracycline antibiotic anticancer drug. |
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V4149 | Aldoxorubicin HCl (INNO-206) | 480998-12-7 | Aldoxorubicin HCl (formerly MC-DOXHZN; INNO-206; Doxo-EMCH; INNO206), the hydrochloride salt ofAldoxorubicin, is a albumin-binding prodrug of doxorubicin (an anthracycline antibiotic anticancer drug, and a DNA topoisomerase II inhibitor). |
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V52397 | ARN-21934 | 2230854-93-8 | ARN-21934 is a specific, BBB (blood-brain barrier) permeable (penetrable) inhibitor of human topoisomerase II α. |
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V52396 | ARN24139 | 2699768-78-8 | ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor (antagonist) with IC50 of 7.3 μM. |
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V56570 | Belotecan-d7 hydrochloride (belotecan d7 hydrochloride) | 1346598-22-8 | Belotecan-d7 ( HCl) is the deuterium labelled form of Belotecan HCl. |
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V3352 | Bimolane | 74550-97-3 | Bimolane (also known asAT-1727) is a novel, potent topoisomerase II inhibitor that has been widely used for the treatment of cancer, psoriasis, and uveitis in humans. |
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V12770 | Bisantrene HCl (CL-216942, NSC-337766) | 71439-68-4 | Bisantrene HCl (CL216942 and NSC337766), the hydrochloride salt ofBisantrene, is potent inhibitor of topoisomerase II and DNA intercalators with anticancer activity. |
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V52261 | CH-0793076 TFA (TP3076 TFA) | 2740278-76-4 | CH-0793076 (TP3076) TFA, a hexacyclic analog of camptothecin, is the active drug and major metabolite of TP300. |
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V55708 | CL2-MMT-SN38 | 1084888-82-3 | CL2-MMT-SN38 is an analogue of SN-38. |
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V52199 | Datopotamab deruxtecan (DS-1062; Dato-DXd) | 2238831-60-0 | Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast surface antigen 2 (TROP2)-directed antibody-active molecular conjugate (ADC). |
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V3828 | Ellipticine | 519-23-3 | Ellipticine, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). |
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V3829 | Ellipticine HCl | 5081-48-1 | Ellipticine HCl, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). |
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V55709 | Elomotecan hydrochloride (BN 80927) | 220997-99-9 | Elomotecan HCl (BN 80927) is a potent inhibitor of topoisomerase I and II. |
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