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Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.

Topoisomerase related products

Structure Cat No. Product Name CAS No. Product Description
(1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) V78993 (1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f) 2938875-39-7 (1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate.
(1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) V55245 (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) 2938875-54-6 (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate .
(4-NH2)-Exatecan V55246 (4-NH2)-Exatecan 2495742-21-5 (4-NH2)-Exatecan is a topoisomerase inhibitor analogue that may be utilized in the synthesis/preparation of active molecules for antibody conjugation (ADC).
(4-NH2)-Exatecan-d5 V88354 (4-NH2)-Exatecan-d5 (4-NH2)-Exatecan-d5 is a deuterated (4-NH2)-Exatecan.
(5-Cl)-Exatecan V88362 (5-Cl)-Exatecan 2813268-66-3 (5-Cl)-Exatecan (compound 1-5) is a potent inhibitor of DNA topoisomerase and can be used in cancer research.
(R)-(4-NH2)-Exatecan V88359 (R)-(4-NH2)-Exatecan (R)-(4-NH2)-Exatecan is the R-isomer of (4-NH2)-Exatecan (compound A).
10-羟基喜树碱 V3121 (±)-10-Hydroxycamptothecin 64439-81-2 10-Hydroxycamptothecin, a naturally occuring indole alkaloid isolated from Camptotheca acuminate, is a cell-permeable and potent inhibitor of topoisomerase I.
12-Ethyl-9-hydroxycamptothecin V56564 12-Ethyl-9-hydroxycamptothecin 119577-28-5 12-Ethyl-9-hydroxycamptothecin is an analogue of Camptothecin.
2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan V88395 2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan 2964536-59-0 2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan is a drug-linker conjugate for ADC, which consists of a cleavable linker and Exatecan.
3-Fluoro-evodiamine glucose V88791 3-Fluoro-evodiamine glucose 3-Fluoro-evodiamine glucose (Compound 8) is a evodiamine-glucose conjugate.
9-Chloromethyl-10-hydroxy-11-F-Camptothecin V55247 9-Chloromethyl-10-hydroxy-11-F-Camptothecin 2414594-22-0 9-Chloromethyl-10-Hydroxy-11-F-Camptothecin? is a new camptothecin analogue.
ADC Control Human IgG1-Deruxtecan V88373 ADC Control Human IgG1-Deruxtecan ADC Control Human IgG1-Deruxtecan is a human monoclonal antibody that is an isotype control for ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I.
AHr V78289 AHr AuM1Phe is an N-heterocyclic carbene (NHC) metal complex that blocks human topoisomerase I activity and actin polymerization.
Alloc-DOX V88254 Alloc-DOX 561022-65-9 Alloc-DOX (N-Alloc doxorubicin) is a prodrug of doxorubicin.
Antibacterial agent 229 V88802 Antibacterial agent 229 Antibacterial agent 229 (compound 8a) is a potent antibacterial agent.
Anticancer agent 214 V88798 Anticancer agent 214 2916404-95-8 Anticancer agent 214 (2) is a camptothecin compound with IC50 values of 2.6 nM and 15.7 nM for MCF-7 and MDA-MB-231 cells, respectively.
Anticancer agent 215 V88793 Anticancer agent 215 2916404-93-6 Anticancer agent 215 (1) is a camptothecin compound with IC50 values of 5.2 nM and 8.2 nM for MCF-7 and MDA-MB-231 cells, respectively.
Anticancer agent 218 V88794 Anticancer agent 218 2916406-46-5 Anticancer agent 218 (P136) is a camptothecin compound with anticancer activity.
ARN-21934 V52397 ARN-21934 2230854-93-8 ARN-21934 is a specific, BBB (blood-brain barrier) permeable (penetrable) inhibitor of human topoisomerase II α.
ARN24139 V52396 ARN24139 2699768-78-8 ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor (antagonist) with IC50 of 7.3 μM.
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