NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The redox-dependent signaling cascades, innate immunity, hormone production, and other physiological processes depend on the ROS produced by NADPH oxidases. They also act as cofactors in these processes.
The seven members of the NOX enzyme family of transmembrane proteins—NOX1 through NOX5, as well as DUOX1 and DUOX2—each have a unique tissue distribution and activation mechanism. They facilitate the conversion of molecular oxygen into superoxide anion, which then catalyzes the rapid reaction that produces other ROS, including hydrogen peroxide. Although minimal NOX activity is essential for healthy physiology, NOX enzyme overactivity results in disease. NADPH oxidases are becoming more and more popular as drug targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2231 | APX-115 | 1270084-92-8 | APX-115, also known as EWHA 18278,is a novel,potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. |
|
V73266 | Diapocynin (Dehydrodiacetovanillone) | 29799-22-2 | Diapocynin (DeHydrodiacetovanillone) is a dimeric analogue of Apocynin and an orally bioactive NADPH oxidase inhibitor. |
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V21614 | GKT136901 | 955272-06-7 | GKT136901 is a novel and potent NOX1/4 inhibitor acting by blocking tumor angiogenesis through a PPARα mediated mechanism and selective scavenging of peroxynitrite (PON). |
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V73264 | GKT136901 hydrochloride | 1254507-01-1 | GKT136901 HCl is a specific and orally bioactive NADPH oxidase NOX-1/4 inhibitor (antagonist) with Kis of 160 and 165 nM respectively. |
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V3830 | GLX351322 | 835598-94-2 | GLX351322 is a new NOX4 (NADPH oxidase 4) inhibitor which has relative NOX4 selectivity over NOX2 with with an IC50 of 5 μ M inhibiting hydrogen peroxide production from NOX4-overexpressing cells. |
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V73267 | GLX481304 | 701224-63-7 | GLX481304 is a specific inhibitor of Nox-2 and -4 with IC50 of 1.25 μM. |
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V79694 | GLX481369 | GLX481369 is a redox active substance. | |
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V73272 | gp91 ds-tat | 329902-61-6 | gp91 ds-tat is a biologically active peptide. |
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V3562 | GSK2795039 | 1415925-18-6 | GSK2795039 is a novel and potentsmall moleculeNADPH oxidase 2inhibitor with a meanpIC50of 6 in different cell-free assays. |
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V50911 | NADP+ | 604-79-5 | oxidized form of NADPH |
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V73268 | NADPH oxidase-IN-1 | 2762405-17-2 | NADPH oxidase-IN-1 is an orally bioavailable inhibitor of NADPH oxidase (Nox), which is associated with neuronal inflammation. |
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V73269 | NOX2-IN-2 | 2648709-79-7 | NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. |
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V73270 | Noxa A BH3 | 505070-09-7 | Noxa A BH3 is a biologically active peptide. |
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V73271 | Noxa B BH3 | 505070-10-0 | Noxa B BH3 is a biologically active peptide. |
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V73265 | NoxA1ds | 1435893-78-9 | NoxA1ds is a highly efficient and selective Nox1 (NADPH oxidase isoform 1) inhibitor. |
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V80967 | NoxA1ds TFA | NoxA1ds TFA is a potent and specific NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). | |
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V73263 | p67phox-IN-1 | 306969-25-5 | p67phox-IN-1 (Formula IIIa) is an inhibitor (blocker/antagonist) of the interaction between Rac GTPase and p67phox protein. |
|
V81270 | r8-Gly-Noxa A BH3 | r8-Gly-Noxa A BH3 is a biologically active peptide. | |
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V1904 | Setanaxib (GKT137831) | 1218942-37-0 | Setanaxib (also known as GKT-137831; GTK831) is anovel, specific, potent, orally bioavailable, and dual inhibitor of NADPH oxidase NOX1/NOX4 with Ki of 110 nM and 140 nM, respectively. |
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V27951 | VAS 2870 | 722456-31-7 | VAS2870 is an NADPH oxidase (NOX) inhibitor. |
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