NADPH Oxidase

NADPH Oxidase

NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The redox-dependent signaling cascades, innate immunity, hormone production, and other physiological processes depend on the ROS produced by NADPH oxidases. They also act as cofactors in these processes.

The seven members of the NOX enzyme family of transmembrane proteins—NOX1 through NOX5, as well as DUOX1 and DUOX2—each have a unique tissue distribution and activation mechanism. They facilitate the conversion of molecular oxygen into superoxide anion, which then catalyzes the rapid reaction that produces other ROS, including hydrogen peroxide. Although minimal NOX activity is essential for healthy physiology, NOX enzyme overactivity results in disease. NADPH oxidases are becoming more and more popular as drug targets.

NADPH Oxidase related products

Structure Cat No. Product Name CAS No. Product Description
V2231 APX-115 1270084-92-8 APX-115, also known as EWHA 18278,is a novel,potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
V73266 Diapocynin (Dehydrodiacetovanillone) 29799-22-2
V21614 GKT136901 955272-06-7
V73264 GKT136901 hydrochloride 1254507-01-1
V3830 GLX351322 835598-94-2 GLX351322 is a new NOX4 (NADPH oxidase 4) inhibitor which has relative NOX4 selectivity over NOX2 with with an IC50 of 5 μ M inhibiting hydrogen peroxide production from NOX4-overexpressing cells.
V73267 GLX481304 701224-63-7
V79694 GLX481369
V73272 gp91 ds-tat 329902-61-6
V3562 GSK2795039 1415925-18-6 GSK2795039 is a novel and potentsmall moleculeNADPH oxidase 2inhibitor with a meanpIC50of 6 in different cell-free assays.
V50911 NADP+ 604-79-5 oxidized form of NADPH
V73268 NADPH oxidase-IN-1 2762405-17-2
V73269 NOX2-IN-2 2648709-79-7
V73270 Noxa A BH3 505070-09-7
V73271 Noxa B BH3 505070-10-0
V73265 NoxA1ds 1435893-78-9
V80967 NoxA1ds TFA
V73263 p67phox-IN-1 306969-25-5
V81270 r8-Gly-Noxa A BH3
V1904 Setanaxib (GKT137831) 1218942-37-0 Setanaxib (also known as GKT-137831; GTK831) is anovel, specific, potent, orally bioavailable, and dual inhibitor of NADPH oxidase NOX1/NOX4 with Ki of 110 nM and 140 nM, respectively.
V27951 VAS 2870 722456-31-7 VAS 2870 is a NADPH oxidase (Nox) inhibitor that enhances TGF-β-induced apoptosis of liver tumor cells.
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