Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.The GR regulates the genes that affect growth, metabolism, and immune response and is expressed in practically all body cells. The control of gene transcription is the main method by which the glucocorticoid receptor functions when it binds to glucocorticoids.The cell's cytosol is home to the unbound receptor. The receptor-glucocorticoid complex can proceed in one of two ways after the glucocorticoid and receptor are bonded together. By inhibiting other transcription factors from moving from the cytosol into the nucleus, the activated GR complex controls the expression of anti-inflammatory proteins in the nucleus or suppresses the expression of pro-inflammatory proteins in the cytoplasm. Dexamethasone is an agonist, while cyproterone acetate and RU486 are GR antagonists. Progesterone and DHEA have opposing effects on the GR as well.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67739 | 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 37413-91-5 | 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate in the synthesis/preparation of delta 9,11 steroids, such as Vamorolone. |
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V67735 | BAY 1003803 | 1152781-51-5 | BAY 1003803 is a glucocorticoid receptor agonist (activator) indicated for topical investigation in psoriasis or severe atopic dermatitis. |
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V67743 | Beclomethasone-d5 (Beclomethasone d5) | 1263143-48-1 | Beclomethasone-d5 is the deuterium labelled form of Beclomethasone. |
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V67747 | Betamethasone dipropionate-d10 (Betamethasone 17,21-dipropionate-d10) | 2280940-19-2 | Betamethasone dipropionate-d10 is the deuterium labelled form of Betamethasone dipropionate. |
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V67738 | Budesonide impurity C | 1040085-99-1 | Budesonide impurity C is an impurity in Budesonide. |
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V67740 | Ciclesonide-d7 (Ciclesonide-d7) | 1225382-70-6 | Ciclesonide-d7 is the deuterated form of Ciclesonide. |
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V67730 | Dazucorilant (CORT113176) | 1496508-34-9 | Dazucorilant (CORT113176) is a non-steroidal glucocorticoid receptor (GR) modulator with an in vitro Ki of <1 nM. |
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V67727 | Glucocorticoid receptor agonist-1 | 2166375-82-0 | Glucocorticoid receptor agonist-1 is a potent and specific glucocorticoid receptor agonist/activator with IC50 of 2.8 nM. |
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V67736 | Glucocorticoid receptor agonist-1-Gly-Gly-Glu-Gly-Br | 2913234-81-6 | Glucocorticoid receptor agonist (activator)-1-Gly-Gly-Glu-Gly-Br is a steroid-Linker conjugate used for the synthesis of protein-linked immunoconjugates. |
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V67729 | Glucocorticoid receptor agonist-2 | 2166378-92-1 | Glucocorticoid receptor agonist-2 (compound 21) is a glucocorticoid receptor agonist/activator with IC50 of 6.6 nM. |
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V67737 | Glucocorticoid receptor modulator 2 | 2452396-89-1 | Glucocorticoid receptor modulator 2 (Example 1) is a glucocorticoid receptor modulator with IC50 of less than 100 nM. |
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V67746 | Glucocorticoids receptor agonist 1 | 694526-54-0 | Glucocorticoids receptor agonist (activator) 1 is a potent anti~inflammatory, arylpyrazole glucocorticoid receptor agonist (activator) that does not impair insulin secretion. |
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V67741 | Glucocorticoids receptor agonist 2 | 614761-20-5 | Glucocorticoids receptor agonist (activator) 2 is a potent anti~inflammatory, arylpyrazole glucocorticoid receptor agonist (activator) that does not impair insulin secretion. |
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V67733 | GSK9027 | 1229096-88-1 | GSK9027 is a nonsteroidal glucocorticoid receptor (GR) agonist that behaves as a partial agonist on the 2× glucocorticoid response element (GRE) reporter system and achieves intrinsic activity relative to dexamethasone. |
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V67742 | HP210 | 728039-52-9 | HP210 is a selective glucocorticoid receptor modulator (SGRM). |
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V5626 | Prednisolone Phosphate Sodium | 125-02-0 | Prednisolone sodium phosphate is a water soluble form of prednisolone and a glucocorticoid with anti-inflammatory and immunomodulating properties. |
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V67734 | Zavacorilant | 1781245-13-3 | Zavacorilant modulates the glucocorticoid receptor (GR). |
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