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Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.The GR regulates the genes that affect growth, metabolism, and immune response and is expressed in practically all body cells. The control of gene transcription is the main method by which the glucocorticoid receptor functions when it binds to glucocorticoids.The cell's cytosol is home to the unbound receptor. The receptor-glucocorticoid complex can proceed in one of two ways after the glucocorticoid and receptor are bonded together. By inhibiting other transcription factors from moving from the cytosol into the nucleus, the activated GR complex controls the expression of anti-inflammatory proteins in the nucleus or suppresses the expression of pro-inflammatory proteins in the cytoplasm. Dexamethasone is an agonist, while cyproterone acetate and RU486 are GR antagonists. Progesterone and DHEA have opposing effects on the GR as well.

Glucocorticoid Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(-)-ZK 216348 V77401 (-)-ZK 216348 (-)-ZK 216348 is the enantiomer of (+)-ZK 216348.
(22R)-Budesonide V102871 (22R)-Budesonide 51372-29-3 (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of budesonide.
(22R)-Budesonide-d8 V110560 (22R)-Budesonide-d8 85128-75-2 (22R)-BUD-d8 ((22R)-BUD-d8) is deuterated (22R)-BUD.
(R)-GSK866 V88954 (R)-GSK866 1094607-80-3 (R)-GSK866 is the R-enantiomer of GSK866.
11β-Hydroxyetiocholanolone V123085 11β-Hydroxyetiocholanolone 739-26-4 11β-Hydroxyetiocholanolone is a metabolite of hydrocortisone.
2-O-trans-p-Coumaroylalphitolic acid V86855 2-O-trans-p-Coumaroylalphitolic acid 67911-63-1 2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpenoid extracted from the jujube plant.
20α-Dihydro prednisolone V103092 20α-Dihydro prednisolone 15847-24-2 20α-Dihydroprednisolone is a metabolite of prednisolone.
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione V67739 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate in the synthesis/preparation of delta 9,11 steroids, such as Vamorolone.
21-Desacetyldeflazacort-d5 V86852 21-Desacetyldeflazacort-d5 21-Desacetyldeflazacort-d5 is the deuterated form of 21-Desacetyldeflazacort.
6b-Hydroxy triamcinolone acetonide V107579 6b-Hydroxy triamcinolone acetonide 3869-32-7 6b-Hydroxytriamcinolone is a metabolite of the corticosteroid triamcinolone, which is formed from triamcinolone by cytochrome P450 (CYP) isoenzymes CYP3A4, CYP3A5, and CYP3A7.
6β-Hydroxy dexamethasone V103145 6β-Hydroxy dexamethasone 55879-47-5 6β-Hydroxydexamethasone is the active metabolite of the synthetic glucocorticoid dexamethasone.
A-348441 V114514 A-348441 639520-46-0 A-348441 is a liver-selective glucocorticoid receptor antagonist.
ABBV-154 V104000 ABBV-154 ABBV-154 is an anti-TNF antibody-drug conjugate (ADC).
ABBV-3373 V104001 ABBV-3373 ABBV-3373 is an anti-TNF antibody-drug conjugate (ADC).
AL082D06 V2896 AL082D06 256925-03-8 AL082D06 (formerly known as D-06), is a nonsteroidal glucocorticoid receptor (GR) antagonist which is characterized by a tri-aryl methane core chemical structure.
AZD2906 V4249 AZD2906 1034148-15-6 AZD2906 is a novel, potent and selective glucocorticoid receptor (GR)agonist which increases micronucleated immature erythrocytes in the bone marrow of rats.
AZD5423 V4250 AZD5423 1034148-04-3 AZD5423 is the first clinical candidate that displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect, assessed as thymic involution.
AZD7594 V4246 AZD7594 1196509-60-0 AZD7594 (also known as AZ13189620) is a novel, potent selective nonsteroidal indazole ether-based glucocorticoid receptor modulators (SGRMs)with anIC50of 0.9 nM.
BAY 1003803 V67735 BAY 1003803 1152781-51-5 BAY 1003803 is a glucocorticoid receptor agonist (activator) indicated for topical investigation in psoriasis or severe atopic dermatitis.
Beclomethasone-d5 (Beclomethasone d5) V67743 Beclomethasone-d5 (Beclomethasone d5) 1263143-48-1 Beclomethasone-d5 is the deuterium labelled form of Beclomethasone.
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