RGS Protein

RGS Protein

RGS (Regulators of G protein signaling) are protein structural domains that activate GTPases for heterotrimeric G-protein alpha-subunits.GTPase-accelerating RGS proteins have multiple functions, including promoting GTP hydrolysis by heterotrimeric G protein alpha subunits, which inactivates the G protein and quickly cuts off G protein-coupled receptor signaling pathways. Heterotrimeric G proteins exchange GDP for GTP when GPCRs activate them. They are then freed from the receptor and split into an active, free GTP-bound alpha subunit and a beta-gamma dimer, which both trigger downstream effectors.The alpha subunit's hydrolysis of GTP ends the response, allowing it to bind both the receptor and the beta-gamma dimer. RGS proteins stabilize the G protein transition state, thereby significantly reducing the lifetime of GTP-bound alpha subunits. A component of every RGS protein called the RGS-box, or RGS domain, is necessary for its function. RGS1 and RGS4, two tiny RGS proteins, are essentially just RGS domains, but others have extra domains that add extra functionality.

RGS Protein related products

Structure Cat No. Product Name CAS No. Product Description
V2394 CCG 50014 883050-24-6 CCG 50014 is a novel, potent and selective inhibitor of RGS4 with IC50 of 30 nM.
V4959 CCG-63802 620112-78-9 CCG-63802 is a novel, selective and reversible inhibitor of RGS4 (regulator of G-protein signaling) with IC50 value of 1.9 μM.
V4958 CCG-63808 620113-73-7 CCG-63808 is a novel, potent and reversible inhibitor of regulator of G-protein signaling (RGS) proteins with IC50 value of 1.4 μM for RGS4.
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