Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation.Both the start codon and translation initiation regulation are provided by these proteins, which also aid in stabilizing the development of the functioning ribosome around it.
A guanine nucleotide-exchange protein called eukaryotic initiation factor 2B (eIF2B) facilitates the conversion of GDP (bound to eIF2) into GTP, hence replenishing the active [eIF2.GTP] complex necessary for peptide chain initiation. An important regulator of eukaryotic protein synthesis, eIF2B activity changes in response to viral infection, hormones, nutrition, growth factors, and specific stressors.
The role of eukaryotic translation initiation factor 4E (eIF4E) in the beginning of protein synthesis on capped mRNAs in the cytoplasm is well recognized. The initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome, is composed of the eukaryotic initiation factor (elF) 4A as a subunit.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V37649 | Didesmethylrocaglamide | 177262-30-5 | Didesmethylrocaglamide is a naturally occurring rocaglamide type of 1H-cyclopenta[b]benzofuran lignans isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis). |
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V31579 | GCN2iB | 2183470-12-2 | GCN2iB is a novel, potent and ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM. |
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