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Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.

Cytochrome P450 related products

Structure Cat No. Product Name CAS No. Product Description
V60135 CYP1B1-IN-4 2685779-55-7 CYP1B1-IN-4 is a selective CYP1B1 (IC50=0.2 nM) 2,4-diarylthiazole compound.
(3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) V73938 (3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) 1428118-38-0 (3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin.
(3S,5S)-阿托伐他汀钠 V20588 ent-Atorvastatin 501121-34-2 ent-Atorvastatin [(3S,5S)-Atorvastatin] is an inactive isomer/enantiomer of Atorvastatin, which is a HMGCR (HMG-CoA reductase) inhibitor and an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic drug.
(E/Z)-DMU2139 V89626 (E/Z)-DMU2139 104890-70-2 (E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139.
(R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) V86130 (R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) 57344-88-4
(R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) V73959 (R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) 264234-05-1 (R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively.
(R)-Mephenytoin ((-)-Mephenytoin) V73942 (R)-Mephenytoin ((-)-Mephenytoin) 71140-51-7 (R)-Mephenytoin ((-)-Mephenytoin) is the R-enantiomer of mephenytoin.
(Rac)-Ketoconazole V101730 (Rac)-Ketoconazole 79156-75-5 (Rac)-ketoconazole ((Rac)-R 41400) is an orally available antifungal imidazole compound.
(S)-Desmethylcitalopram V102169 (S)-Desmethylcitalopram 144025-14-9 (S)-Norcitalopram is an isomer of norcitalopram hydrochloride.
(S)-Mephenytoin ((+)-Mephenytoin) V73972 (S)-Mephenytoin ((+)-Mephenytoin) 70989-04-7 (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant (antiepileptic/antiseizure).
(±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) V73928 (±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) 93879-40-4 (±)-N-3-Benzylnirvanol is a racemic mixture (racemate) of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol.
(±)-ε-Viniferin V83684 (±)-ε-Viniferin 253435-07-3
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) V84216 (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) 197508-62-6
1'-Hydroxy bufuralol V73976 1'-Hydroxy bufuralol 57704-16-2 1'-Hydroxy bufuralol is the major metabolite of bufuralol and reflects the activity of CYP2D.
1-(Isothiazol-3-yl)ethan-1-one V94921 1-(Isothiazol-3-yl)ethan-1-one 88511-35-7 1-(Isothiazol-3-yl)ethan-1-one (Q11) is a CYP2E1 inhibitor.
1-Ethynylpyrene V73931 1-Ethynylpyrene 34993-56-1 1-Ethynylpyrene is an inhibitor (blocker/antagonist) of cytochrome P450 1A1, 1A2 and 2B1 with IC50 of 0.18, 0.32 and 0.04 μM respectively.
1-氨基苯并三唑 V4419 1-Aminobenzotriazole 1614-12-6 1-Aminobenzotriazole (also known as ABT; 3-Aminobenzotriazole) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes.
17(S)-HETE V87183 17(S)-HETE 183509-25-3 17S-HETE is an arachidonic acid metabolite produced through the cytochrome P-450 pathway.
17-HETE V87181 17-HETE 128914-47-6 17-HETE is an arachidonic acid metabolite produced through the cytochrome P-450 pathway and consists of 17R-HETE and 17S-HETE enantiomers.
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- V60140 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- 186299-00-3 hCYP3A4 Fluorogenic Substratum 1 is a potent form of hCYP3A4 fluid.Having a Km value of 0.36 μM.
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