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Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.

Cytochrome P450 related products

Structure Cat No. Product Name CAS No. Product Description
V60135 CYP1B1-IN-4 2685779-55-7 CYP1B1-IN-4 is a selective CYP1B1 (IC50=0.2 nM) 2,4-diarylthiazole compound.
(3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) V73938 (3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) 1428118-38-0 (3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin.
(R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) V86130 (R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) 57344-88-4
(R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) V73959 (R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) 264234-05-1 (R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively.
(R)-Mephenytoin ((-)-Mephenytoin) V73942 (R)-Mephenytoin ((-)-Mephenytoin) 71140-51-7 (R)-Mephenytoin ((-)-Mephenytoin) is the R-enantiomer of mephenytoin.
(S)-Mephenytoin ((+)-Mephenytoin) V73972 (S)-Mephenytoin ((+)-Mephenytoin) 70989-04-7 (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant (antiepileptic/antiseizure).
(±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) V73928 (±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) 93879-40-4 (±)-N-3-Benzylnirvanol is a racemic mixture (racemate) of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol.
(±)-ε-Viniferin V83684 (±)-ε-Viniferin 253435-07-3
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) V84216 (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) 197508-62-6
1'-Hydroxy bufuralol V73976 1'-Hydroxy bufuralol 57704-16-2 1'-Hydroxy bufuralol is the major metabolite of bufuralol and reflects the activity of CYP2D.
1-Aminobenzotriazole V4419 1-Aminobenzotriazole 1614-12-6 1-Aminobenzotriazole (also known as ABT; 3-Aminobenzotriazole) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes.
1-Ethynylpyrene V73931 1-Ethynylpyrene 34993-56-1 1-Ethynylpyrene is an inhibitor (blocker/antagonist) of cytochrome P450 1A1, 1A2 and 2B1 with IC50 of 0.18, 0.32 and 0.04 μM respectively.
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- V60140 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- 186299-00-3 hCYP3A4 Fluorogenic Substratum 1 is a potent form of hCYP3A4 fluid.Having a Km value of 0.36 μM.
2,6-Dimethylquinoline V73962 2,6-Dimethylquinoline 877-43-0 2,6-Dimethylquinoline, a natural component from Peucedantu praeruptorum roots, is an inhibitor (blocker/antagonist) of CYP1A2 with IC50 of 3.3 µM.
20-HETE inhibitor-1 V73948 20-HETE inhibitor-1 2472030-28-5 20-HETE inhibitor-1 (comp 83) is an inhibitor (blocker/antagonist) of 20-HETE synthesis.
3-CETC V9500 3-CETC 117620-77-6 3-CETC (3-Cyano-7-ethoxycoumarin) is a novel and potent fluorescent CYP1A1 &1A2 substrate.
4,5-Dimethoxycanthin-6-one V73963 4,5-Dimethoxycanthin-6-one 18110-87-7 4,5-Dimethoxycanthin-6-one is a potent, noncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with IC50 of 1.7 μM and a Ki of 2.6 μM.
5,7,2',6'-Tetrahydroxyflavone V73979 5,7,2',6'-Tetrahydroxyflavone 82475-00-1 5,7,2',6'-Tetrahydroxyflavone is a naturally occurring flavonoid that can inhibit hepatic testosterone 6β-hydroxylation (CYP3A4) activity with IC50 of 7.8 μM.
5,7-Dimethoxyflavone V40552 5,7-Dimethoxyflavone 21392-57-4 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora and has anti-obesity, anti~inflammatory and anti-tumor effects.
6',7'-Dihydroxybergamottin (6',7'-DHB) V73981 6',7'-Dihydroxybergamottin (6',7'-DHB) 145414-76-2 6',7'-Dihydroxybergamomottin (6',7'-DHB) is a furanocoumarin that can inhibit CYP3A4 and is present in grapefruit juice and Seville orange juice.
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