Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V60135 | CYP1B1-IN-4 | 2685779-55-7 | CYP1B1-IN-4 is a selective CYP1B1 (IC50=0.2 nM) 2,4-diarylthiazole compound. |
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V73938 | (3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) | 1428118-38-0 | (3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin. |
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V20588 | ent-Atorvastatin | 501121-34-2 | ent-Atorvastatin [(3S,5S)-Atorvastatin] is an inactive isomer/enantiomer of Atorvastatin, which is a HMGCR (HMG-CoA reductase) inhibitor and an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic drug. |
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V89626 | (E/Z)-DMU2139 | 104890-70-2 | (E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139. |
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V86130 | (R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) | 57344-88-4 | |
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V73959 | (R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) | 264234-05-1 | (R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively. |
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V73942 | (R)-Mephenytoin ((-)-Mephenytoin) | 71140-51-7 | (R)-Mephenytoin ((-)-Mephenytoin) is the R-enantiomer of mephenytoin. |
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V101730 | (Rac)-Ketoconazole | 79156-75-5 | (Rac)-ketoconazole ((Rac)-R 41400) is an orally available antifungal imidazole compound. |
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V102169 | (S)-Desmethylcitalopram | 144025-14-9 | (S)-Norcitalopram is an isomer of norcitalopram hydrochloride. |
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V73972 | (S)-Mephenytoin ((+)-Mephenytoin) | 70989-04-7 | (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant (antiepileptic/antiseizure). |
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V73928 | (±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) | 93879-40-4 | (±)-N-3-Benzylnirvanol is a racemic mixture (racemate) of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. |
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V83684 | (±)-ε-Viniferin | 253435-07-3 | |
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V84216 | (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) | 197508-62-6 | |
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V73976 | 1'-Hydroxy bufuralol | 57704-16-2 | 1'-Hydroxy bufuralol is the major metabolite of bufuralol and reflects the activity of CYP2D. |
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V107736 | 1,2,3,4,7,8-Hexachlorodibenzofuran | 70648-26-9 | 1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) promotes the expression of CYP1A1, CYP1B1, and aryl hydrocarbon receptor inhibitor (AhRR) genes in human peripheral blood lymphocytes (PBL). |
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V107707 | 1,2,3,6,7,8-Hexachlorodibenzofuran | 57117-44-9 | 1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a polychlorinated dibenzofuran (PCDF). |
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V94921 | 1-(Isothiazol-3-yl)ethan-1-one | 88511-35-7 | 1-(Isothiazol-3-yl)ethan-1-one (Q11) is a CYP2E1 inhibitor. |
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V73931 | 1-Ethynylpyrene | 34993-56-1 | 1-Ethynylpyrene is an inhibitor (blocker/antagonist) of cytochrome P450 1A1, 1A2 and 2B1 with IC50 of 0.18, 0.32 and 0.04 μM respectively. |
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V4419 | 1-Aminobenzotriazole | 1614-12-6 | 1-Aminobenzotriazole (also known as ABT; 3-Aminobenzotriazole) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes. |
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V107157 | 11-HETE | 73804-65-6 | 11-HETE (11-hydroxy-5,8,12,14-eicosatetraenoic acid) is an activator of cytochrome P450. |