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Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.

Cytochrome P450 related products

Structure Cat No. Product Name CAS No. Product Description
V60135 CYP1B1-IN-4 2685779-55-7 CYP1B1-IN-4 is a selective CYP1B1 (IC50=0.2 nM) 2,4-diarylthiazole compound.
(3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) V73938 (3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) 1428118-38-0 (3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin.
(3S,5S)-阿托伐他汀钠 V20588 ent-Atorvastatin 501121-34-2 ent-Atorvastatin [(3S,5S)-Atorvastatin] is an inactive isomer/enantiomer of Atorvastatin, which is a HMGCR (HMG-CoA reductase) inhibitor and an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic drug.
(E/Z)-DMU2139 V89626 (E/Z)-DMU2139 104890-70-2 (E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139.
(R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) V86130 (R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate) 57344-88-4
(R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) V73959 (R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) 264234-05-1 (R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively.
(R)-CYP3cide V121917 (R)-CYP3cide (R)-CYP3cide is the R isomer of CYP3cide.
(R)-Esomeprazole V111813 (R)-Esomeprazole 119141-89-8 (R)-Esomeprazole ((R)-Omeprazole; (+)-Omeprazole) is an orally effective regulator of cytochrome P450 (C450) 2C19, CYP3A4 and CYP2C9-related metabolic processes.
(R)-Mephenytoin ((-)-Mephenytoin) V73942 (R)-Mephenytoin ((-)-Mephenytoin) 71140-51-7 (R)-Mephenytoin ((-)-Mephenytoin) is the R-enantiomer of mephenytoin.
(R)-N-3-Benzylnirvanol V111547 (R)-N-3-Benzylnirvanol 790676-41-4 (R)-N-3-benzylniervano is the R-isomer of (±)-N-3-benzylniervano.
(Rac)-Ketoconazole V101730 (Rac)-Ketoconazole 79156-75-5 (Rac)-ketoconazole ((Rac)-R 41400) is an orally available antifungal imidazole compound.
(Rac)-δ-Viniferin V110369 (Rac)-δ-Viniferin (Rac)-δ-glucantin is a racemic mixture of δ-glucantin and ε-glucantin isomers.
(S)-Aminoglutethimide V112003 (S)-Aminoglutethimide 57288-03-6 (S)-Aminoglutate is an aromatase inhibitor.
(S)-Desmethylcitalopram V102169 (S)-Desmethylcitalopram 144025-14-9 (S)-Norcitalopram is an isomer of norcitalopram hydrochloride.
(S)-Mephenytoin ((+)-Mephenytoin) V73972 (S)-Mephenytoin ((+)-Mephenytoin) 70989-04-7 (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant (antiepileptic/antiseizure).
(S)-Pulegone V122212 (S)-Pulegone 3391-90-0 (S)-Pulegone is a substrate of cytochrome P450 (CYP450).
(±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) V73928 (±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) 93879-40-4 (±)-N-3-Benzylnirvanol is a racemic mixture (racemate) of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol.
(±)-ε-Viniferin V83684 (±)-ε-Viniferin 253435-07-3 (±)-ε-Viniferin is a racemic form of ε-Viniferin.
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) V84216 (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) 197508-62-6
(±)5(6)-EET Ethanolamide V121221 (±)5(6)-EET Ethanolamide (±)5(6)-EET Ethanolamide is a metabolite produced by the oxidation of arachidonic acid ethanolamine (Anandamide) by cytochrome P450 enzymes.
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