The peptide hormones cholecystokinin (CCK) and gastrin are bound by a class of G-protein coupled receptors known as cholecystokinin receptors. Cholecystokinin A receptor (CCK-AR), which is primarily found on pancreatic acinar cells, and CCK-BR, which is primarily found in the stomach and nervous system tissues, have both been identified as the endogenous receptors of CCK. Both have high affinity for gastrin, but only the CCK-BR has high affinity for the sulfated CCK octapeptide (CCK-8).
A peptide hormone called CCK was found in the small intestine. The traditional triad of gut hormones includes secretin, gastrin, and CCK. In addition to controlling gallbladder contraction, CCK also controls intestinal motility, satiety signaling, pancreatic enzyme secretion and growth, and the inhibition of gastric acid secretion. In central and intestinal neurons, CCK also functions as a transceiver.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V118661 | BBL454 | BBL454 (compound 43) is a cholecystokinin 2B (CCK2B) receptor agonist. | |
|
V118561 | BC264 | BC264 is a highly potent and selective CCK-B agonist capable of crossing the blood-brain barrier. | |
|
V111027 | CCKBR agonist-1 | 2923120-30-1 | CCKBR agonist-1 (compound 3r1) is a Gq protein-biased cholecystokinin type B receptor (CCKBR) agonist with an EC50 value of 35 pM. |
|
V111022 | CCKBR agonist-2 | 923714-61-8 | CCKBR agonist-2 (compound z-44) is a Gi-biased CCKBR agonist. |
|
V116866 | CI-988 meglumin | 130404-91-0 | CI-988 meglumin is a cholecystokinin 2 receptor (CCK2R) antagonist. |
|
V118710 | FE100726 | 158459-39-3 | FE100726 (compound 39) is a cholecystokinin 2 (CCK2) receptor agonist. |
|
V118604 | FE101120 | FE101120 is a non-peptide CCK2 receptor agonist. | |
|
V116041 | PF-04756956 | 1228934-52-8 | PF-04756956 is a potent type 1 cholecystokinin receptor (CCK1R) agonist (EC50 = 0.47 nM). |
|
V116272 | S-0509 | 171724-30-4 | S-0509 is a selective CCKB/gastrin receptor antagonist. |
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V14030 | Loxiglumide | 107097-80-3 | Loxiglumide is a potent, orally bioavailable, and selective CCK-A receptor antagonist which stimulates calorie intake and hunger feelings in humans. |
|
V14810 | Sincalide (CCK-8) | 25126-32-3 | Sincalide (CCK-8) is a cholecystokinetic drug used to treat cholecystitis and to diagnose disorders of the gallbladder and pancreas. |
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V26248 | Nastorazepide (Z-360) | 209219-38-5 | Nastorazepide, formerly known as Z-360, is a selective, orally bioavailable, 1,5-benzodiazepine-analogue gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. |
|
V12862 | Caerulein (Caerulein; Cerulein; FI-6934) | 17650-98-5 | Caerulein (Caerulein; Cerulein; FI-6934) is a novel, potent and specific decapeptide-based cholecystokinin receptor agonist, it is produced in the skin of Hila caerulea, an Australian amphibian. |
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