Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate the oncogene eIF4E on serine 209.According to reports, this phosphorylation is necessary for the protein's oncogenic activity. The translational machinery's essential cog, eukaryotic initiation factor 4E (eIF4E), plays a crucial role in controlling cell growth and proliferation. Inhibitory binding proteins (4E-BPs) are thought to interact with eIF4E to control its activity, and mitogen-activated protein kinase-interacting kinase (MNK), which is activated in response to mitogens and cellular stress, phosphorylates eIF4E on Ser209.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1941 | CGP 57380 | 522629-08-9 | CGP57380 (CGP-57380) is a potent,cell-permeable and selcetiveMNK1 inhibitor with anticancer activity. |
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V74101 | MNK inhibitor 9 | 1889336-59-7 | MNK inhibitor 9 is a potent and specific MNK1/2 inhibitor (antagonist) with IC50s of 0.003 µM and 0.003 µM respectively. |
|
V31746 | SLV-2436 | 2095704-43-9 | SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively. |
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V20752 | Tinodasertib (ETC-206) | 1464151-33-4 | ETC-206 is a novel, potent and selective MNK1/2 inhibitor with IC50 of 64 nM for MNK1 and IC50 of 84 nM for MNK2. |
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V2662 | Tomivosertib (eFT-508) | 1849590-01-7 | Tomivosertib (also known as eFT508) is a potent, highly selective, reversible, ATP-competitive and orally bioavailable inhibitor of MNK1 and MNK2 (Mitogen-Activated Protein Kinase Interacting Kinase) with IC50 values of 1-2 nM against both isoforms in enzyme assays. |
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