Dopamine Receptor

Dopamine Receptor

In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.

Dopamine Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V84344 (+)-UH 232 (UH 232) 95999-12-5
V19599 (-)-Quinpirole HCl 85798-08-9 Quinpirole HCl [(-)-LY 171555] is a highly potent psychoactive drug and research chemical which acts as a high affinity and selective D₂ and D₃ receptor agonist.
V71727 (R)-Preclamol ((+)-3-PPP) 85976-54-1 (R)-Preclamol is a dopamine (DA) agonist/activator with autoreceptor and postsynaptic receptor stimulating properties.
V71759 (R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride) 89874-80-6 (R)-Preclamol HCl ((+)-3-PPP HCl) is the R-enantiomer of Preclamol HCl.
V71721 (Rac)-PF-06256142 1609580-97-3 (Rac)-PF-06256142 is the weaker enantiomer of PF-06256142.
V71728 (Rac)-Razpipadon (PW0464) 1643462-93-4 PW0464 is a full G protein ligand with nanomolar activity and an agonist of D1R with EC50 of 5.8 nM (Gs-cAMP).
V71221 (Rac)-Rotigotine (N-0437) 92206-54-7 (Rac)-Rotigotine (N-0437) is the racemate of Rotigotine.
V71718 (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) 1643462-64-9 (Rac)-Tavapadon ((Rac)-PF-06649751) is a specific, non-catecholic dopamine D1 receptor agonist.
V71732 [18F]-Labeled L-dopa precursor 1614253-58-5 [18F]-Labeled L-dopa precursor is a precursor used to synthesize 18F-labeled L-dopa.
V9846 A-381393 726174-00-1 A-381393 is a potent, selective, BBB (blood-brain barrier) permeable/penetrable dopamine D4 receptor blocker (antagonist) with Kis of 1.5, 1.9 and 1.6 for human dopamine D4.4, D4.2 and D4.7 receptors respectively.
V71753 A-412997 dihydrochloride 1347744-96-0 A-412997 di-HCl is a selective dopamine D4 receptor agonist that improves cognitive performance in rats.
V71745 A-77636 778546-51-3 A-77636 is an orally bioactive, selective, long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM).
V71716 A68930 hydrochloride 130465-39-3 A68930 HCl, as a dopamine D1 receptor agonist (activator), may be utilized in the research/study of bronchiectasis.
V9995 ABT-724 70006-24-5 ABT-724 isa novel,potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM.
V40042 ABT-724 trihydrochloride 587870-77-7 ABT-724 trihydrochloride is a novel, potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM.
V84575 AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) 85379-09-5
V84316 AJ-76 hydrochloride ((+)-AJ 76 hydrochloride; (1S,2R)-AJ 76 hydrochloride) 85378-82-1
V1255 Alizapride HCl 59338-87-3 Alizapride HCl (Limican; Plitican; Vergentan; Superan; Alizaprida; Litican; MS-5080), the hydrochloride salt of alizapride which is a medication used for the theropy of nausea and vomiting, is a potent dopamine receptor antagonist with prokinetic and antiemetic effects.
V1257 Amantadine HCl 665-66-7 Amantadine HCl (EXP-105-1; GP 38026; ADS5102; Influenol; Midantan; Midantane; Mydantane; NSC 83653; Symadine; Symmetrel; Trivaline; Virasol; Viregyt; Virofral; Virosol),the hydrochloride salt of amantadine, is an approved medication used to treat or prevent infections of the respiratory tract caused by a certain virus.
V1250 Amfebutamone HCl 31677-93-7 Amfebutamone HCl (Bupropion, Wellbutrin, Zyban; BW-323; NSC315851; NSC-315851), the hydrochloride salt of Amfebutamone, is a potent and selective norepinephrine-dopamine reuptake inhibitor used as an antidepressant and for smoking cessation.
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