In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V19599 | (-)-Quinpirole HCl | 85798-08-9 | Quinpirole HCl [(-)-LY 171555] is a highly potent psychoactive drug and research chemical which acts as a high affinity and selective D₂ and D₃ receptor agonist. |
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V71727 | (R)-Preclamol ((+)-3-PPP) | 85976-54-1 | (R)-Preclamol is a dopamine (DA) agonist/activator with autoreceptor and postsynaptic receptor stimulating properties. |
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V71759 | (R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride) | 89874-80-6 | (R)-Preclamol HCl ((+)-3-PPP HCl) is the R-enantiomer of Preclamol HCl. |
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V71721 | (Rac)-PF-06256142 | 1609580-97-3 | (Rac)-PF-06256142 is the weaker enantiomer of PF-06256142. |
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V71728 | (Rac)-Razpipadon (PW0464) | 1643462-93-4 | PW0464 is a full G protein ligand with nanomolar activity and an agonist of D1R with EC50 of 5.8 nM (Gs-cAMP). |
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V71221 | (Rac)-Rotigotine (N-0437) | 92206-54-7 | (Rac)-Rotigotine (N-0437) is the racemate of Rotigotine. |
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V71718 | (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) | 1643462-64-9 | (Rac)-Tavapadon ((Rac)-PF-06649751) is a specific, non-catecholic dopamine D1 receptor agonist. |
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V71732 | [18F]-Labeled L-dopa precursor | 1614253-58-5 | [18F]-Labeled L-dopa precursor is a precursor used to synthesize 18F-labeled L-dopa. |
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V9846 | A-381393 | 726174-00-1 | A-381393 is a potent, selective, BBB (blood-brain barrier) permeable/penetrable dopamine D4 receptor blocker (antagonist) with Kis of 1.5, 1.9 and 1.6 for human dopamine D4.4, D4.2 and D4.7 receptors respectively. |
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V71753 | A-412997 dihydrochloride | 1347744-96-0 | A-412997 di-HCl is a selective dopamine D4 receptor agonist that improves cognitive performance in rats. |
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V71745 | A-77636 | 778546-51-3 | A-77636 is an orally bioactive, selective, long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). |
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V71716 | A68930 hydrochloride | 130465-39-3 | A68930 HCl, as a dopamine D1 receptor agonist (activator), may be utilized in the research/study of bronchiectasis. |
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V9995 | ABT-724 | 70006-24-5 | ABT-724 isa novel,potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM. |
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V40042 | ABT-724 trihydrochloride | 587870-77-7 | ABT-724 trihydrochloride is a novel, potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM. |
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V1255 | Alizapride HCl | 59338-87-3 | Alizapride HCl (Limican; Plitican; Vergentan; Superan; Alizaprida; Litican; MS-5080), the hydrochloride salt of alizapride which is a medication used for the theropy of nausea and vomiting, is a potent dopamine receptor antagonist with prokinetic and antiemetic effects. |
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V1257 | Amantadine HCl | 665-66-7 | Amantadine HCl (EXP-105-1; GP 38026; ADS5102; Influenol; Midantan; Midantane; Mydantane; NSC 83653; Symadine; Symmetrel; Trivaline; Virasol; Viregyt; Virofral; Virosol),the hydrochloride salt of amantadine, is an approved medication used to treat or prevent infections of the respiratory tract caused by a certain virus. |
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V1250 | Amfebutamone HCl | 31677-93-7 | Amfebutamone HCl (Bupropion, Wellbutrin, Zyban; BW-323; NSC315851; NSC-315851), the hydrochloride salt of Amfebutamone, is a potent and selective norepinephrine-dopamine reuptake inhibitor used as an antidepressant and for smoking cessation. |
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V1271 | Amisulpride (DAN 2163) | 71675-85-9 | Amisulpride (Solian; Amazeo; Amipride; Amival; Soltus; Aminosultopride; DAN-2163; DAN2163; Deniban; Amisulprida; Sulpitac; Sulprix) is a potent and atypical antipsychotic medication used to treat psychosis in schizophrenia and episodes of mania in bipolar disorders. |
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V11154 | Amisulpride HCl | 81342-13-4 | Amisulpride HCl (Barhemsys; Solian; Amazeo; Aminosultopride; Amipride; Amival; Deniban; Amisulprida; Soltus; DAN-2163; Sulpitac; Sulprix), the hydrochloride salt of Amisulpride, is an atypical antipsychotic medication approved for treating psychosis in schizophrenia and episodes of mania in bipolar disorders. |
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V71769 | Amisulpride-d5 (amisulpride d5) | 1216626-17-3 | Amisulpride-d5 is the deuterium labelled form of Amisulpride. |
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