In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V108931 | FMJ-01-042 | FMJ-01-042 is a low-potency partial agonist that can cross the blood-brain barrier and has high affinity (Kᵢ=4.33 nM) and strong subtype selectivity for dopamine D4 receptors. | |
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V114361 | Piquindone | 78541-97-6 | Praziquantel (Ro 22-1319) is a potent antipsychotic drug. |
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V115099 | UNC9815 | UNC9815 is a positive allosteric modulator (PAM) of the D1 dopamine receptor (D1R). | |
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V115254 | S 33138 | 245514-32-3 | S33138 is a D3 receptor antagonist. |
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V115309 | PD 172760 | 200195-01-3 | PD 172760 (CI 1030) is a selective D4 receptor antagonist. |
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V116980 | Aramisulpride hydrochloride | 2129505-46-8 | Amisupilyl hydrochloride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. |
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V108974 | FMJ-01-054 | FMJ-01-054 is a selective dopamine D4 receptor (D4R) antagonist with a Ki value of 77.7 nM. | |
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V112688 | Pipotiazine palmitate | 37517-26-3 | Piperothiazine palmitate is a dopamine receptor antagonist. |
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V112734 | Mergocriptine | 81968-16-3 | Ergocryptine (CBM36-733) is a dopamine receptor agonist and also a SARS-CoV-2 Mpro ligand. |
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V115390 | 7-Hydroxy-DPAT | 74938-11-7 | 7-Hydroxy-DPAT (7-OH-DPAT) is a selective D3 dopamine receptor agonist. |
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V117123 | PD 128483 | 115688-97-6 | PD 128483 is a selective dopamine autoreceptor agonist. |
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V117172 | (Z)-Flupenthixol decanoate | 69079-98-7 | (Z)-Fluoperthixene decanoate is the cis isomer of fluoperthixene decanoate. |
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V118713 | Tetrahydropapaveroline hydrobromide | 16659-88-4 | Tetrahydropapain (norlaxine) hydrobromide is an isoquinoline alkaloid, a condensation product of dopamine and dopaaldehyde. |
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V120085 | SRI-45949 | SRI-45949 is an allosteric modulator of HIV-DAT-Tat interaction. | |
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V120075 | Thiethylperazine-d3 | Thietoperazine-d3 is a deuterium-labeled thiaetoperazine. | |
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V112328 | Docarpamine | 74639-40-0 | Docarpamine is an orally effective dopamine prodrug that is converted into active dopamine in the small intestine and liver via hydroxylation. |
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V113307 | VK4-116 | 1982347-43-2 | VK4-116 (compound 19) is a selective dopamine D3 receptor (D3R) antagonist with a Ki value of 6.84 nM. |
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V114608 | BAM-1110 | 155210-57-4 | BAM-1110 is a dopamine receptor agonist. |
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V114578 | BRL 34778 | 86580-77-0 | BRL 34778 is a potent, selective, and orally effective dopamine D2 receptor antagonist with a Ki value of 2.14 nM. |
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V114591 | SSR-181507 hydrochloride | 223502-85-0 | SSR-181507 hydrochloride is a dopamine D2 receptor antagonist and a 5-HT1A receptor agonist. |
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