A type-I interferon response is triggered by the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS). When self or microbial DNA enters the cytoplasm, cGAS binds to it and catalyzes the synthesis of cGAMP. The production of type-I IFNs is then triggered by cGAMP acting as a second messenger that binds to and activates the endoplasmic reticulum protein STING. STING attracts TBK1, which phosphorylates substrates like IKK, cRel, and p62 as well as transcription factors like IRF3/7.
In Huntington disease (HD), cGAS plays a crucial role in controlling inflammatory and autophagic responses. Age-related macular degeneration and cellular senescence are two conditions that cGAS can significantly affect by inducing signaling that is known to promote the up-regulation of inflammatory genes. This shows that there is a strong molecular and signaling connection between the inflammatory response and autophagy.cGAS also plays a significant role in the regulation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V115262 | cGAS-IN-6 | 3105027-33-3 | cGAS-IN-6 (14) is a cGAS inhibitor. |
|
V110981 | cGAS-IN-7 | cGAS-IN-7 is a cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 value of 0.66 μM for human cGAS. | |
|
V110860 | cGAS-IN-8 | cGAS-IN-8 is an indazole cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 value of 6 nM for human cGAS. | |
|
V51739 | G-140 | 2369751-07-3 | G140 is a potent and sensitive conjugate of GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. |
|
V4559 | PF-06928215 | 2378173-15-8 | PF-06928215 (PF06928215) is a novel, potent,high affinity and selectivecGAS (cyclic GMP-AMP Synthase)inhibitor with the potential to be used for autoimmune diseases and inflammatory conditions. |
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