A type-I interferon response is triggered by the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS). When self or microbial DNA enters the cytoplasm, cGAS binds to it and catalyzes the synthesis of cGAMP. The production of type-I IFNs is then triggered by cGAMP acting as a second messenger that binds to and activates the endoplasmic reticulum protein STING. STING attracts TBK1, which phosphorylates substrates like IKK, cRel, and p62 as well as transcription factors like IRF3/7.

In Huntington disease (HD), cGAS plays a crucial role in controlling inflammatory and autophagic responses. Age-related macular degeneration and cellular senescence are two conditions that cGAS can significantly affect by inducing signaling that is known to promote the up-regulation of inflammatory genes. This shows that there is a strong molecular and signaling connection between the inflammatory response and autophagy.cGAS also plays a significant role in the regulation of autophagy.

cGAS related products

Structure Cat No. Product Name CAS No. Product Description
G-140 V51739 G-140 2369751-07-3 G140 is a potent and sensitive conjugate of GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.
PF-06928215 V4559 PF-06928215 2378173-15-8 PF-06928215 (PF06928215) is a novel, potent,high affinity and selectivecGAS (cyclic GMP-AMP Synthase)inhibitor with the potential to be used for autoimmune diseases and inflammatory conditions.
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