A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V60100 | (E)-Coniferin | 124151-33-3 | (E)-Coniferin is a solution of Coniferin. |
|
V60102 | (R)-(+)-Corypalmine | 13063-54-2 | |
|
V51714 | (±)-trans-Nerolidol | 40716-66-3 | Trans-nerolidol (trans-nerolidol) is a sesquiterpene alcohol. |
|
V51010 | Antibacterial agent 67 | 2488900-01-0 | The inhibitory activity of antibacterial agent 67 (IC50 = 0.03 μM) as an enzyme inhibitor of acid dehydrogenase was significantly higher than that of fluorophosphotidol (IC50 = 4.40 μM). |
|
V11513 | APX001A (Manogepix; E 1210) | 936339-60-5 | APX001A (Manogepix, E1210) is a first-in-class,broad-spectrum and orally bioactive inhibitor of the fungal protein Gwt1 (GPI-anchored wall transfer protein 1) in the glycosylphosphatidylinositol (GPI) biosynthesis pathway. |
|
V16569 | Butoconazole Nitrate (RS35887) | 64872-77-1 | Butoconazole Nitrate (RS-35887) is a synthetic imidazole analog with fungistatic/antifungal properties. |
|
V20179 | Efinaconazole | 164650-44-6 | Efinaconazole(formerly AGJ-95634;KP-103; CTK-5J2975; KB-145948; trade names Jublia; Clenafin) is a triazole antifungal drug approved for use in various countries such as the United States, Canada, and Japan as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nails). |
|
V5136 | Flucytosine (5-Fluorocytosine, 5-FC, Ancobon) | 2022-85-7 | Flucytosine (also known as 5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is a potent and oral antifungal drug that is structurally related to the cytostatic fluorouracil and to floxuridine. |
|
V51185 | Fosmanogepix (APX-001; E-1211) | 2091769-17-2 | Fosmanogepix (APX001) is a broad-spectrum antifungal agent against fungal infections. |
|
V50995 | Fungicide-5 | 2344721-61-3 | Fungicide5 is a candidate fungicide targeting succinate dehydrogenase (Ki = 0.095 μM). |
|
V5132 | Hexetidine (NSC-17764) | 141-94-6 | Hexetidine (NSC17764; NSC-17764) is a potent anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. |
|
V25514 | Miconazole nitrate (R18134 nitrate) | 22832-87-7 | Miconazole nitrate(R18134 nitrate) is an 14-α demethylase inhibitor and potential glucocorticoid receptor antagonist that inhibits ergosterol synthesis and fungal cell wall formation. |
|
V50942 | Nifuroxime (CCRIS-1180) | 6236-05-1 | Nifuroxime is an anti-infection agent utilized in the research related to fungal infections. |
|
V51016 | SDH-IN-2 | 1823354-06-8 | SDH-IN-2 is a potent succinate dehydrogenase (SDH) mold with IC50 of 0.55 μg/mL. |
|
V14671 | Sertaconazole Nitrate (Ertaczo, Dermofix, Konzert, and Zalain) | 99592-39-9 | Sertaconazole nitrate (Ertaczo, Dermofix, Konzert, and Zalain) is atopical broad-spectrumantifungal medication of the imidazole class. |
|
V15791 | Tavaborole | 174671-46-6 | Tavaborole (formerly known as AN-2690; AN2690;trade name Kerydin) is a topical antifungal medication approved by the US FDA in July 2014 for the treatment of onychomycosis, which is a fungal infection of the nail and nail bed. |
|
V60116 | Tetradehydropodophyllotoxin | 42123-27-3 | Tetradehydropodophyllotoxin has antifungal activity. |
|
V5138 | Tioconazole (UK-20349) | 65899-73-2 | Tioconazole (formerly known as UK-20349) is a potent imidazole-based antifungal medication that has been approved for the treatment of infections caused by a fungus or yeast. |
|
V5139 | Tolnaftate (NP-27) | 2398-96-1 | Tolnaftate (formerly NP-27; trade names: Tinactin, Tinaderm, Aftate) is a synthetic thiocarbamate used as an anti-fungal agent that may be sold as an OTC drug. |
|
V51741 | Trifloxystrobin-d6 | 2470226-50-5 | Trifloxystrobin-d6 is the deuterated form of Trifloxystrobin. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
