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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol 2407559-34-4 (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
2′-Hydroxychalcone V89726 2′-Hydroxychalcone 1214-47-7 2'-Hydroxychalcone is a hydroxy derivative of chalcone with anticancer activity.
8-Acetylverrucarin L V91114 8-Acetylverrucarin L 77101-88-3 8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin with antitumor and antibacterial activities.
Acremine I V91076 Acremine I 1110661-29-4 Acremine I is a fungicide and a metabolite of the endophytic fungus Acremonium byssoides.
Amycolatopsin B V91774 Amycolatopsin B 2209112-97-8 Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
Ansatrienin A V88250 Ansatrienin A 82189-03-5 Ansatrienin A is an antifungal antibiotic isolated from Streptomyces collinus.
Antibacterial agent 67 V51010 Antibacterial agent 67 2488900-01-0 The inhibitory activity of antibacterial agent 67 (IC50 = 0.03 μM) as an enzyme inhibitor of acid dehydrogenase was significantly higher than that of fluorophosphotidol (IC50 = 4.40 μM).
Antibiotic WB V91120 Antibiotic WB 247919-66-0 Antibiotic WB is an antibiotic with antifungal activity, which can be isolated from soil fungus strain 38.
Antifungal agent 100 V92168 Antifungal agent 100 2975157-18-5 Antifungal agent 100 (compound 3i) exhibited significant antifungal activity against S. sclerotiorum with an EC50 value of 0.33 mg/L.
Antifungal agent 91 V90771 Antifungal agent 91 Antifungal agent 91 (compound 1) is a dihydroflavonol isolated from the leaves of Artocarpus elasticus.
APX001A (Manogepix; E 1210) V11513 APX001A (Manogepix; E 1210) 936339-60-5 APX001A (Manogepix, E1210) is a first-in-class,broad-spectrum and orally bioactive inhibitor of the fungal protein Gwt1 (GPI-anchored wall transfer protein 1) in the glycosylphosphatidylinositol (GPI) biosynthesis pathway.
AS-2077715 V91012 AS-2077715 1637356-98-9 AS-2077715 is an antifungal agent that exhibits inhibitory activity against Trichophyton spp.
Burnettramic acid A V91775 Burnettramic acid A 2334483-46-2 Burnettramic acid A is an antibiotic isolated from Aspergillus burnettii.
Chaetoviridin A V91050 Chaetoviridin A 128252-98-2 Chaetoviridin A exhibits antifungal activity against a variety of plant pathogens and inhibits the growth of Verticillium dahliae through cell necrosis and hyphal deformation, thereby increasing the sensitivity of Verticillium dahliae to stress and improving the emergence rate and plant height of cotton.
Cinnamon bark oil, from Cinnamonum zeylanicum Blume V92149 Cinnamon bark oil, from Cinnamonum zeylanicum Blume 8015-91-6 Cinnamon bark oil, from Cinnamonum zeylanicum Blume, is a mycotoxicant that has toxic effects on fungi that cause respiratory mycoses.
Concanamycin C V91034 Concanamycin C 81552-34-3 Concanamycin C inhibits the proliferation of mouse spleen lymphocytes.
D-四氢药根碱 V60102 (R)-(+)-Corypalmine 13063-54-2
Elsinochrome A V89191 Elsinochrome A 24568-67-0 Elsinochrome A is a perylenequinone photosensitizer that can generate reactive oxygen species under light excitation, inducing apoptosis and autophagy.
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