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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
(E)-Coniferin V60100 (E)-Coniferin 124151-33-3 (E)-Coniferin is a solution of Coniferin.
(R)-(+)-Corypalmine V60102 (R)-(+)-Corypalmine 13063-54-2
(±)-trans-Nerolidol V51714 (±)-trans-Nerolidol 40716-66-3 Trans-nerolidol (trans-nerolidol) is a sesquiterpene alcohol.
2′-Hydroxychalcone V89726 2′-Hydroxychalcone 1214-47-7 2'-Hydroxychalcone is a hydroxy derivative of chalcone with anticancer activity.
8-Acetylverrucarin L V91114 8-Acetylverrucarin L 77101-88-3 8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin with antitumor and antibacterial activities.
Acremine I V91076 Acremine I 1110661-29-4 Acremine I is a fungicide and a metabolite of the endophytic fungus Acremonium byssoides.
Ansatrienin A V88250 Ansatrienin A 82189-03-5 Ansatrienin A is an antifungal antibiotic isolated from Streptomyces collinus.
Antibacterial agent 67 V51010 Antibacterial agent 67 2488900-01-0 The inhibitory activity of antibacterial agent 67 (IC50 = 0.03 μM) as an enzyme inhibitor of acid dehydrogenase was significantly higher than that of fluorophosphotidol (IC50 = 4.40 μM).
Antibiotic WB V91120 Antibiotic WB Antibiotic WB is an antibiotic with antifungal activity, which can be isolated from soil fungus strain 38.
Antifungal agent 91 V90771 Antifungal agent 91 Antifungal agent 91 (compound 1) is a dihydroflavonol isolated from the leaves of Artocarpus elasticus.
APX001A (Manogepix; E 1210) V11513 APX001A (Manogepix; E 1210) 936339-60-5 APX001A (Manogepix, E1210) is a first-in-class,broad-spectrum and orally bioactive inhibitor of the fungal protein Gwt1 (GPI-anchored wall transfer protein 1) in the glycosylphosphatidylinositol (GPI) biosynthesis pathway.
AS-2077715 V91012 AS-2077715 1637356-98-9 AS-2077715 is an antifungal agent that exhibits inhibitory activity against Trichophyton spp.
Butoconazole Nitrate (RS35887) V16569 Butoconazole Nitrate (RS35887) 64872-77-1 Butoconazole Nitrate (RS-35887) is a synthetic imidazole analog with fungistatic/antifungal properties.
Chaetoviridin A V91050 Chaetoviridin A 128252-98-2 Chaetoviridin A exhibits antifungal activity against a variety of plant pathogens and inhibits the growth of Verticillium dahliae through cell necrosis and hyphal deformation, thereby increasing the sensitivity of Verticillium dahliae to stress and improving the emergence rate and plant height of cotton.
Concanamycin C V91034 Concanamycin C 81552-34-3 Concanamycin C inhibits the proliferation of mouse spleen lymphocytes.
Efinaconazole V20179 Efinaconazole 164650-44-6 Efinaconazole(formerly AGJ-95634;KP-103; CTK-5J2975; KB-145948; trade names Jublia; Clenafin) is a triazole antifungal drug approved for use in various countries such as the United States, Canada, and Japan as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nails).
Elsinochrome A V89191 Elsinochrome A 24568-67-0 Elsinochrome A is a perylenequinone photosensitizer that can generate reactive oxygen species under light excitation, inducing apoptosis and autophagy.
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