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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol 2407559-34-4 (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
(Gly0.8Nap0.2)20 V103811 (Gly0.8Nap0.2)20 (Gly0.8Nap0.2)20 is a dual-targeting compound against fungal membranes and DNA.
(RS)-Sakuranetin V102712 (RS)-Sakuranetin 520-29-6 (RS)-Sakuranetin is the racemate of Sakuranetin.
(±)-Dunnione V102647 (±)-Dunnione 521-49-3 (±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
10-Undecenoic acid (copper) V105650 10-Undecenoic acid (copper) 35322-29-3 Copper 10-undecenoate (undecylenate) was used as the starting reagent for the synthesis of the pheromone (11Z)-hexadecenal.
13-Hydroxy-9-octadecenoic acid V97796 13-Hydroxy-9-octadecenoic acid 324575-43-1 13-Hydroxy-9-octadecenoic acid is a hydroxyunsaturated fatty acid (HUFA) with antifungal activity.
14α-Demethylase-IN-1 V94976 14α-Demethylase-IN-1 3026164-55-3 14α-Demethylase-IN-1 (Compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent.
2′-Hydroxychalcone V89726 2′-Hydroxychalcone 1214-47-7 2'-Hydroxychalcone is a hydroxy derivative of chalcone with anticancer activity.
2,3,5-Tri-O-benzyl-D-ribose V106715 2,3,5-Tri-O-benzyl-D-ribose 54623-25-5 2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is a potent inhibitor of chitin synthase (CHS) from Botrytis cinerea with IC50 of 1.8 μM.
2,3-Dichloro-1,4-naphthoquinone V105685 2,3-Dichloro-1,4-naphthoquinone 117-80-6 2,3-Dichloro-1,4-naphthoquinone is an effective fungicide.
3-GlcA-28-AraRhaxyl-medicagenate V97799 3-GlcA-28-AraRhaxyl-medicagenate 128192-15-4 3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family.
6-O-Methylreticulol V105943 6-O-Methylreticulol 24350-93-4 6-O-Methylreticulin (compound 1a) is an isocoumarin isolated from an endophytic fungus of the mangrove plant Avicennia marina in the Pearl River Estuary in southern China.
6-Prenylindole V102421 6-Prenylindole 23158-16-9 6-Isopentenyl indole is an antifungal agent that can be isolated from Streptomyces sp.
8-Acetylverrucarin L V91114 8-Acetylverrucarin L 77101-88-3 8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin with antitumor and antibacterial activities.
9-OxoOTrE V102830 9-OxoOTrE 125559-74-2 9-OxoOTrE (9-KOTrE) is an antifungal agent that exhibits inhibitory activity against B. cinerea, C. herbarum, P. infestans, and P. parasitica via an electrophilic mechanism.
Acremine I V91076 Acremine I 1110661-29-4 Acremine I is a fungicide and a metabolite of the endophytic fungus Acremonium byssoides.
AEC5 V101746 AEC5 2035042-31-8 AEC5 is a lipopeptide with antifungal activity against Cryptococcus neoformans infection.
Alternariol, methyl ether V101926 Alternariol, methyl ether 26894-49-5 Alternaria methyl ether is a common mycotoxin in spoiled grains, which has mutagenic and carcinogenic effects in vitro.
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