Angiotensin II serves as the ligand for the class of G protein-coupled receptors known as angiotensin receptors. They play a crucial role in the renin-angiotensin system as they are involved in the signal transduction of the main effector hormone, angiotensin II's, vasoconstricting stimulus. Angiotensin II, their primary ligand, has a similar affinity for the AT1 and AT2 receptors. The angiotensin receptor that has been most thoroughly characterized is AT1. The fetus and newborn have a higher concentration of AT2 receptors. The AT3 and AT4 receptors are additional understudied subtypes.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V75301 | 1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone | 120693-52-9 | Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). | |
V77338 | [Sar1, Ile8]-Angiotensin II TFA (AngiotensinII TFA; Angiotensin 2 TFA) | [Sar1, Ile8]-Angiotensin II (TFA) is a polypeptide that has multiple effects in vascular smooth muscle cells such as contraction of normal arteries, hypertrophy or proliferation of cultured cells or diseased blood vessels, etc. | ||
V75293 | [Tyr(P)4] Angiotensin II | 129785-85-9 | [Tyr(P)4] Angiotensin II is a polypeptide that has multiple effects in vascular smooth muscle cells such as contraction of normal arteries, hypertrophy or proliferation of cultured cells or diseased blood vessels, etc. | |
V77261 | Angiotensin I/II (1-5) (TFA) | Angiotensin I/II 1-5 TFA is a polypeptide consisting of 1-5 amino acid (AA)s, converted from angiotensin I/II peptide. | ||
V77260 | Angiotensin I/II (1-6) (TFA) | Angiotensin I/II (1-6) TFA contains 1-6 amino acid (AA)s and is converted from angiotensin I/II peptide. | ||
V77259 | Angiotensin II (3-8), human TFA | Angiotensin II (3-8), human (TFA) is a less active angiotensin AT1 receptor agonist (activator). | ||
V77258 | Angiotensin III, human, mouse TFA | Angiotensin III, human, mouse (TFA) is an angiotensin. | ||
V75290 | Angiotensinogen (1-13) (human) | 82048-97-3 | Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen, a naturally occurring renin substrate and the precursor of all angiotensin peptides | |
V79495 | Antihypertensive agent 2 | Antihypertensive agent 2 (Compound 4g) is an antihypertensive agent. | ||
V78008 | Antihypertensive agent 3 | Antihypertensive agent 3 (compound 4a) is an angiotensin II receptor 1 antagonist. | ||
V75296 | AT1R antagonist 1 | 2848719-80-0 | AT1R antagonist 1 (compound 10) is a potent AT1R selective ligand. | |
V75291 | AT1R antagonist 2 | 2848719-76-4 | AT1R antagonist 2 (compound 6) is a potent AT1R selective ligand. | |
V86527 | AT1R antagonist 3 | AT1R antagonist 3 (Compound 1) is an antagonist of angiotensin II type 1 receptor (AT1R) and an inhibitor of L-type calcium channel CaV1. | ||
V84474 | AT2 receptor ligand-1 | |||
V11927 | AVE 0991 | 304462-19-9 | AVE-0991 is a novel, orally bioactive non-peptide mimic and high affinity agonist of angiotensin-(1-7) (IC50 = 21 nM) with important cardioprotective bioactivity. | |
V75289 | Azilsartan mepixetil potassium (QR-01019K) | 2153458-32-1 | Azilsartan mepixetil potassium (QR-01019K) is an angiotensin II receptor antagonist. | |
V75280 | Azilsartan methyl ester | 147403-52-9 | Azilsartanmethylester is an analogue of Azilsartan, an angiotensin II receptor blocker (antagonist) that plays important roles in hypertension. | |
V75285 | Azilsartan mopivabil | 2271428-31-8 | Azilsartan mopivabil is a potent antagonist of angiotensin II receptor. | |
V77186 | Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) | Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a polypeptide containing 32 amino acid (AA)s. | ||
V11787 | AT2 Agonist C21 (M24) | 477775-14-7 | AT2 Agonist C21(M-24) is a novel, potent and selective agonist of angiotensin AT2 receptors with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively. |