Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor

The basic helix-loop-helix transcription factor family includes the cytoplasmic receptor and transcription factor known as aryl hydrocarbon receptor (AhR or AHR). Exogenous and endogenous ligands of various types can either activate or inhibit the AhR. When it comes to immunity and tissue homeostasis, AhR plays a crucial role. A variety of structurally different substances, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can activate AhR.

Indigooids, heme metabolites, eicosanoids, tryptophan derivatives, and equilenin are examples of endogenous ligands. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, natural substances, and small molecule substances are examples of exogenous ligands. Because AhR ligands differ in their shapes and characteristics, their interactions with AhR have unique biological effects.

Hsp90, AIP, and p23 are examples of chaperone proteins that sequester unliganded AHR in the cytoplasm. AHR moves into the nucleus after ligand binding and forms a heterodimer with ARNT. The aryl hydrocarbon response elements, which are found in the regulatory regions of target genes like CYP1A1, CYP1B1, and TIPARP, are where the AHR-ARNT complex regulates transcription by binding with high affinity.

Aryl Hydrocarbon Receptor related products

Structure Cat No. Product Name CAS No. Product Description
3-OH-Kynurenamine V74745 3-OH-Kynurenamine 99362-47-7 3-OH-Kynurenamine is a lateral metabolite in the metabolism of Tryptophan.
6,2',4'-Trimethoxyflavone V51688 6,2',4'-Trimethoxyflavone 720675-74-1 6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist.
AHR agonist 4 V80526 AHR agonist 4 AHR agonist 4 (compound 24e) is an agonist of the aryl hydrocarbon receptor AHR and is related to the immune balance of Th17/22 and Treg cells.
AHR antagonist 5 hemimaleate V78602 AHR antagonist 5 hemimaleate AHR antagonist 5 hemimaleate is a potent, orally bioactive aryl hydrocarbon receptor (AHR) antagonist (inhibitor) with IC50 of < 0.5 μM.
AHR antagonist 6 V84334 AHR antagonist 6 378223-81-5
Benvitimod (Tapinarof) V3650 Benvitimod (Tapinarof) 79338-84-4 Benvitimod (Tapinarof; WB1001;GSK2894512) is a naturally occurringaryl hydrocarbon receptor (AhR) agonist (EC50 = 13 nM) approved in China for treatingplaque psoriasis.
Benzyl butyl phthalate V51699 Benzyl butyl phthalate 85-68-7 Butyl phthalate, a member of phthalate esters (PAEs), can cause hemangioma (HA) cells to migrate and increase by upregulating the expression of Zeb1.
Benzyl butyl phthalate-d4 V51083 Benzyl butyl phthalate-d4 93951-88-3 Butyl phthalate, a member of phthalates (PAEs), can cause the migration and body weight of hemangioma (HA) cells by upregulating the expression of Zeb1.
Carbidopa V2129 Carbidopa 28860-95-9 Carbidopa (also known as MK485, MK-485; trade name: Lodosyn; abbreviated as CD), a potent and competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine.
Carbidopa-d3 monohydrate V51696 Carbidopa-d3 monohydrate 1276197-58-0 Carbidopa-d3 (monohydrate) is the deuterated form of carbidopa monohydrate.
CAY10465 V3994 CAY10465 688348-33-6 CAY 10465, an analog of resveratrol, is a novel, potent, selective and high-affinityAhR (aryl hydrocarbon receptor) agonist, with aKiof 0.2 nM, and shows no effect on estrogen receptor (Ki>100000 nM).
CB7993113 V84310 CB7993113 819827-50-4
Flavipin V51693 Flavipin 483-53-4 Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that can induce the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages.
Indolokine A5 V51692 Indolokine A5 951207-88-8 Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist.
KYN-101 V51695 KYN-101 2247950-73-6 KYN-101 is a potent, selective and orally bioactive AHR inhibitor.
L-Kynurenine-13C10 sulfate hydrate V85672 L-Kynurenine-13C10 sulfate hydrate
Norisoboldine hydrochloride V51694 Norisoboldine hydrochloride 5083-84-1 Norisoboldine HCl is a natural aryl hydrocarbon receptor (AhR) agonist/activator with epidermal activity.
PDM2 V4036 PDM2 688348-25-6 PDM-2 (PDM2),a trans-resveratrol analog, is a novel selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with anKiof 1.2±0.4 nM.
YL-109 V2919 YL-109 36341-25-0 YL-109 is a novel anticancer agent which has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.
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