The basic helix-loop-helix transcription factor family includes the cytoplasmic receptor and transcription factor known as aryl hydrocarbon receptor (AhR or AHR). Exogenous and endogenous ligands of various types can either activate or inhibit the AhR. When it comes to immunity and tissue homeostasis, AhR plays a crucial role. A variety of structurally different substances, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can activate AhR.
Indigooids, heme metabolites, eicosanoids, tryptophan derivatives, and equilenin are examples of endogenous ligands. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, natural substances, and small molecule substances are examples of exogenous ligands. Because AhR ligands differ in their shapes and characteristics, their interactions with AhR have unique biological effects.
Hsp90, AIP, and p23 are examples of chaperone proteins that sequester unliganded AHR in the cytoplasm. AHR moves into the nucleus after ligand binding and forms a heterodimer with ARNT. The aryl hydrocarbon response elements, which are found in the regulatory regions of target genes like CYP1A1, CYP1B1, and TIPARP, are where the AHR-ARNT complex regulates transcription by binding with high affinity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V86803 | 1,4-Dihydroxy-2-naphthoic acid | 31519-22-9 | 1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. |
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V86798 | 12(R)-HETE | 82337-46-0 | 12(R)-HETE is a metabolite of arachidonic acid, AA, which is found in psoriasis lesions. |
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V74745 | 3-OH-Kynurenamine | 99362-47-7 | 3-OH-Kynurenamine is a lateral metabolite in the metabolism of Tryptophan. |
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V86805 | 3-OH-Kynurenamine dihydroiodide | 2155855-77-7 | 3-OH-Kynurenamine dihydroiodide is the dihydroiodide salt of 3-OH-Kynurenamine. |
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V51688 | 6,2',4'-Trimethoxyflavone | 720675-74-1 | 6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. |
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V80526 | AHR agonist 4 | 2953023-30-6 | AHR agonist 4 (compound 24e) is an agonist of the aryl hydrocarbon receptor AHR and is related to the immune balance of Th17/22 and Treg cells. |
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V86801 | AhR agonist 6 | 3033281-96-5 | AhR agonist 6 (Compound 6) is an agonist of aryl hydrocarbon receptor (AHR) with EC50 of 0.01 nM. |
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V86800 | AhR agonist 7 | 3033281-98-7 | AhR agonist 7 (Compound 8) has a strong activating activity on AhR (ECsub>50=13 nM). |
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V78602 | AHR antagonist 5 hemimaleate | AHR antagonist 5 hemimaleate is a potent, orally bioactive aryl hydrocarbon receptor (AHR) antagonist (inhibitor) with IC50 of < 0.5 μM. | |
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V84334 | AHR antagonist 6 | 378223-81-5 | |
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V51696 | Carbidopa-d3 monohydrate | 1276197-58-0 | Carbidopa-d3 (monohydrate) is the deuterated form of carbidopa monohydrate. |
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V86799 | CAY10464 | 688348-37-0 | CAY10464 (AHR antagonist 7; compound 4j) is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with Ki of 1.4 nM. |
|
V3994 | CAY10465 | 688348-33-6 | CAY 10465, an analog of resveratrol, is a novel, potent, selective and high-affinityAhR (aryl hydrocarbon receptor) agonist, with aKiof 0.2 nM, and shows no effect on estrogen receptor (Ki>100000 nM). |
|
V84310 | CB7993113 | 819827-50-4 | |
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V86804 | hCYP1B1-IN-2 | hCYP1B1-IN-2 (compound 3n) is a potent inhibitor of the human cytochrome P450 1B1 enzyme hCYP1B1. | |
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V51692 | Indolokine A5 | 951207-88-8 | Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist. |
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V51695 | KYN-101 | 2247950-73-6 | KYN-101 is a potent, selective and orally bioactive AHR inhibitor. |
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V85672 | L-Kynurenine-13C10 sulfate hydrate | ||
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V4036 | PDM2 | 688348-25-6 | PDM-2 (PDM2),a trans-resveratrol analog, is a novel selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with anKiof 1.2±0.4 nM. |
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V86802 | Stemregenin 1 hydrochloride | 2319882-01-2 | Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells with an IC50 value of 127 nM. |
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