Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35125 | (+)-Nortrachelogenin (Wikstromol) | 61521-74-2 | (+)-Nortrachelogenin (Wikstromol) is a pharmacological ligand from wikstroemia indica with anti-leukemic bioactivity. |
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V54827 | (-)-Pinoresinol | 81446-29-9 | (-)-Pinoresinol is a plant-derived tetrahydrofuranolignan that can inhibit α-glucosidase and works as a hypoglycemic agent. |
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V52839 | (E)-C-HDMAPP ammonium | 933030-60-5 | (E)-C-HDMAPP ammonium is a potent phosphoantigen in the ammonium salt form and the pyrophosphate form of (E)-HDMAPP. |
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V54924 | (E)-Mcl-1 inhibitor 7 | 2417463-86-4 | (E)-Mcl-1 inhibitor 7 (Example 34) is a Mcl-1 inhibitor (Ki: <1 nM, IC50= <500 nM). |
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V29589 | (E/Z)-Afatinib ((E/Z)-BIBW 2992) | 439081-18-2 | (E/Z)-Afatinib ((E/Z)-BIBW 2992) is a mixture of (E)-Afatinib and (Z)-Afatinib. |
|
V52760 | (E/Z)-Capsaicin-d3 (capsaicin d3) | 1185237-43-7 | (E/Z)-Capsaicin-d3 is the deuterium labelled form of (E/Z)-Capsaicin. |
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V52937 | (E/Z)-E64FC26 | 2285446-67-3 | (E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26. |
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V53523 | (E/Z)-Eltrombopag-13C4 ((E/Z)-SB-497115-13C4) | 1217230-31-3 | (E/Z)-Eltrombopag-13C4 is a mixture of E-Eltrombopag and Z-Eltrombopag isomers with a 13C label. |
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V52836 | (E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) | 7683-64-9 | (E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpene compound. |
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V77383 | (Gly14)-Humanin (human) (acetate) (14-Glycine-Humanin (human) (acetate)) | (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid (AA) serine is replaced by glycine (Gly). | |
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V55014 | (R)-5,7-Dimethoxyflavanone | 1277188-85-8 | (R)-5,7-Dimethoxyflavanone showed strong antimutagenic activity against MeIQ mutagenesis of Typhimurium TA100 and TA98 strains in the Ames test, and also significantly and dose-dependently inhibited the inflammatory mediator: nitric oxide ( NO) and cytokines (TNF-α and IL-12). |
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V52835 | (R)-OY-101 | 23495-82-1 | (R)-OY-101 is an orally bioactive and specific P-gp inhibitor. |
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V52757 | (Rac)-Hesperetin-d3 | 1346605-26-2 | (Rac)-Hesperetin-d3 is the deuterated form of (Rac)-Hesperetin. |
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V52833 | (Rac)-Indoximod (1-Methyl-DL-tryptophan; (Rac)-NLG-8189) | 26988-72-7 | (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine-2,3-dioxygenase (IDO) inhibitor. |
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V52832 | (S)-(-)-Perillic acid ((S)-(-)-Perillic acid) | 23635-14-5 | (S)-(-)-Perillic acid is a terpenoid plant extract with antibacterial and anti-cancer activity. |
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V3395 | (S)-Thalidomide | 841-67-8 | S)-Thalidomide is the S-enantiomer of thalidomide (brand name Immunoprin) which is an immunomodulatory agent and the prototypic drug of the thalidomide class of drugs that are used mainly for the treatment of certain cancers (e. |
|
V18319 | (±)-8-Prenylnaringenin (racemic 8-prenylnaringenin) | 68682-02-0 | (±)-8-Prenylnaringenin is a natural prenylated flavonoid and a potent phytoestrogen. |
|
V56456 | (±)-Epicatechin-13C3 (Epicatechin 13C3; (-)-Epicatechin 13C3; Epicatechin 13C3; Epicatechin 13C3) | 1217780-28-3 | (±)-Epicatechin-13C3 is 13C (carbon 13)-labeled (±)-Epicatechin. |
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V53127 | (±)-Evodiamine ((±)-Evodiamine) | 518-18-3 | (±)-Evodiamine, a naturally occurring alkaloid, is an inhibitor (blocker/antagonist) of Top1. |
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V52525 | 1,6,7-Trihydroxyxanthone | 25577-04-2 | 1,6,7-Trihydroxyxanthone is a potent anticancer agent. |
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